A5072201399- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Sexual function and dysfunction studies
- Medical Research and Treatments
- Genital Health and Disease
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Pituitary Gland Disorders and Treatments
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Coronary Interventions and Diagnostics
- Hippo pathway signaling and YAP/TAZ
- Pediatric health and respiratory diseases
- Ubiquitin and proteasome pathways
- Urologic and reproductive health conditions
- Urticaria and Related Conditions
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Nanocluster Synthesis and Applications
Huazhong University of Science and Technology
2015-2025
Tongji Hospital
2015-2025
Guangdong Academy of Medical Sciences
2023-2025
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2024-2025
Xinjiang Medical University
2023
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2021
Tianjin Medical University
2018-2020
Abstract Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers. Here we demonstrate that miR-424(322) regulates PD-L1/PD-1 CD80/CTLA-4 pathways in chemoresistant ovarian cancer. is inversely correlated with PD-1, CD80 expression. High levels tumours are positively progression-free survival cancer patients. Mechanistic investigations demonstrated inhibited PD-L1 expression through direct...
Background/Aims: Radiotherapy is the standard treatment option for advanced prostate cancer. Unfortunately, despite significant advances in radiation delivery, cancer radioresistance occurs a large proportion of patients undergoing radiotherapy. As way to enhance radiotherapy effectiveness, research into mechanisms regulating immune response have revived interest combination and immune-based therapies. Methods: miR-195/-16 family PD-L1 levels were analyzed samples from GSE21032 data set....
Kidney renal clear cell carcinoma (KIRC) has high morbidity and gradually increased in recent years, the rate of progression once relapsed is high. At present, owing to lack effective prognosis predicted markers post-recurrence drug selection guidelines, KIRC patients greatly affected. Necroptosis a regulated form necrosis way that independent caspase. Induced necroptosis considered an strategy chemotherapy targeted drugs, it can also be used improve efficacy immunotherapy. Herein, we...
Cerebrovascular disease is the main cause of death in world. Here, we explored whether circulating serum miR-148b-3p, miR-151b and miR-27b-3p could be as potential diagnostic biomarkers for diagnosing acute ischemic stroke. Seventy-seven IS patients forty-two healthy controls matched age sex were enrolled present study. Blood samples drawn from within 24 h. The correlation analysis was performed by Spearman. ability to distinguish determined receiver operating characteristic (ROC) curve....
Bcl-2 family of proteins plays critical roles in human cancers, including pancreatic cancer, suggesting that the discovery specific agents targeting would be extremely valuable for cancer therapy. We have previously reported synthesis and characterization TW-37, which seems to a negative regulator Bcl-2. In this investigation, we tested our hypothesis whether TW-37 could an effective inhibitor cell growth, invasion angiogenesis cells. Using multiple cellular molecular approaches such as MTT...
Calcium/calmodulin-dependentprotein kinase II inhibitor I (CAMK2N1) as one of the tumor suppressor genes is significantly downregulated in prostate cancer (PCa). Reduced expression CAMK2N1 positively correlated with PCa progression. However, mechanisms downregulation are still unclear. The promoter region contains a large number CG loci, providing possibility for DNA methylation. Consequently, we hypothesized that methylation can result reduced PCa. In presented study, level cells and...
Introduction: Previous studies have reported a significant relationship between the baseline Chinese visceral adipose index (CVAI) and risk of new-onset hypertension (NOH). However, long-term effect CVAI NOH remains uncertain. This study aimed to investigate association cumulative NOH. Methods: Data were obtained from China Health Retirement Longitudinal Study 2011 2020. In total, 2836 participants ≥45 years included. Multivariable logistic regression analysis as well restricted cubic spline...
Introduction: Pseudomonas luteola is a rare pathogen that was classified as separate genus in 1987. It highly resistant to drugs and primarily found soil, water, moist environmental areas, rarely infecting humans. Case Presentation: In this study, the pathogenic bacterium P. isolated from necrotic material secretions of patient with chronic osteomyelitis left tibia. Notably, its susceptibility gentamicin study differed previous reports. Conclusions: generally susceptible gentamicin; however,...
Abstract Purpose: Flightless I (FLII), member of the gelsolin superfamily actin-remodeling proteins, functions as a transcriptional coregulator. We aim to evaluate tumor-suppressive function FLII in regulating androgen receptor (AR) prostate cancer progression. Experimental Design: examined protein and mRNA expression clinical specimens by immunohistochemistry. Kaplan–Meier analysis was conducted difference disease-overall survival associated with levels AR. Prostate cells stably expressing...
Prostate cancer at advanced stages including metastatic and castration-resistant remains incurable due to the lack of effective therapies. MiR-190a belongs small noncoding RNA family has an important role in breast metastasis. However, it is still unknown whether miR-190a plays a prostate development. Herein, we first observed AR/miR-190a/YB-1 forms auto-regulatory negative feedback loop cancer: expression was down-regulated by AR activation; YB-1 functions are as activator; inhibited...
Kidney renal clear cell carcinoma (KIRC) is a heterogeneous malignant tumor with high incidence, metastasis, and mortality. The imbalance of copper homeostasis can produce cytotoxicity cause damage. At the same time, also induce death inhibit transformation. latest research found that this copper-induced different from known pathway, so it defined as cuproptosis. We included 539 KIRC samples 72 normal tissues Cancer Genome Atlas (TCGA) in our study. After identifying long non-coding RNAs...
Abstract Oligosaccharins, widely recognized as plant immunity inducers, have been applied and studied for enhancing antiviral defenses in rice over the years. However, due to complex induction mechanism rice, further studies are needed. In this study, we demonstrated that oligosaccharins enhanced resistance southern black-streaked dwarf virus (SRBSDV) at both symptomatic molecular levels. RNA-seq analysis revealed defense by activating multiple pathways. Among them, jasmonic acid (JA)...
Background . BCL6 was a critical prooncogene of human B-cell lymphomas which promoted tumor progress and contributed to malignant behavior in several kinds cancers. This study detect the expression its biological effect on glioma. Methods RT-PCR Western blot were used mRNA protein tissues glioblastoma cell lines. The knockdown two lines (U87 U251) using shRNA. CCK8, colony-formation, flow cytometry, Transwell, wound-healing assays evaluate phenotypic change cells. Results higher glioma than...
Background: Ubiquitin and ubiquitin-like (UB/UBL) conjugations are one of the most important post-translational modifications involve in occurrence cancers. However, biological function clinical significance ubiquitin related genes (URGs) prostate cancer (PCa) still unclear. Methods: The transcriptome data clinicopathological were downloaded from Cancer Genome Atlas (TCGA), which was served as training cohort. GSE21034 dataset used to validate. two datasets removed batch effects normalized...
The morbidity of bladder cancer (BLCA) is high and has gradually elevated in recent years. BLCA also characterized by recurrence invasiveness. Due to the drug resistance lack effective prognostic indicators, prognosis patients with greatly affected. Iron metabolism considered be a pivot tumor occurrence, progression, microenvironment (TME) tumors, but there little research BLCA. Herein, we used univariate COX regression analysis screen 95 prognosis-related iron metabolism-related genes...
Prostate cancer (PCa) has a high incidence rate, mortality and biochemical recurrence (BCR) rate. 7-Methylguanosine (m7G), as one of the RNA modifications, been considered to be actively involved in cancer-related translation disorders recent years. Therefore, we first used The Cancer Genome Atlas (TCGA) database identify prognosis m7G-related long non-coding RNAs (lncRNAs). Then randomly divided samples into training set test then constructed verified m7G lnRNA prognostic model (m7Gscore)...
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare form of adrenal Cushing's syndrome. The slowly progressing expansion tissues usually persists for dozens years, leading to delayed onset with severe conditions due chronic mild hypercortisolism. About 20-50% cases were found be caused by inactivating mutation armadillo repeat-containing protein 5 (ARMC5) gene.