A5101989645- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Pleural and Pulmonary Diseases
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Natural Products and Biological Research
- Traditional Chinese Medicine Analysis
- Photodynamic Therapy Research Studies
- Nuts composition and effects
- Graphene and Nanomaterials Applications
- Hydrogen's biological and therapeutic effects
- Renal and related cancers
- Adrenal and Paraganglionic Tumors
- Cardiovascular Issues in Pregnancy
- Ginseng Biological Effects and Applications
- Forest, Soil, and Plant Ecology in China
- Ubiquitin and proteasome pathways
Shanghai First People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Second Affiliated Hospital of Guangzhou Medical University
2011-2025
Guangzhou Medical University
2011-2025
Institute of Soil Science
2025
University of Chinese Academy of Sciences
2025
Hunan Normal University
2024
Binzhou Medical University
2006-2024
Binzhou University
2011-2024
Guangzhou University
2024
Abstract Oxidative stress is an important molecular mechanism underlying lung fibrosis. The mitochondrion a major organelle for oxidative in cells. Therefore, blocking the mitochondrial signalling pathway may be best therapeutic manoeuver to ameliorate Astaxanthin ( AST ) excellent antioxidant, but no study has addressed of against pulmonary and free radicals by mitochondrion‐mediated pathway. In this study, we investigated antioxidative effects H 2 O ‐ or bleomycin BLM )‐induced dysfunction...
Kidney renal clear cell carcinoma (KIRC) has high morbidity and gradually increased in recent years, the rate of progression once relapsed is high. At present, owing to lack effective prognosis predicted markers post-recurrence drug selection guidelines, KIRC patients greatly affected. Necroptosis a regulated form necrosis way that independent caspase. Induced necroptosis considered an strategy chemotherapy targeted drugs, it can also be used improve efficacy immunotherapy. Herein, we...
The smaller size fraction of plastics may be more substantially existing and detrimental than larger-sized particles. However, reports on nanoplastics (NPs), especially their airborne occurrences potential health hazards to the respiratory system, are scarce. Previous studies limit understanding real effects, since sphere-type polystyrene (PS) nanoparticles differ from NPs occurring in nature with respect physicochemical properties. Here, we employ a mechanical breakdown method, producing...
Recent studies suggest that long non‑coding RNAs (lncRNAs) are more involved in human diseases than previously realized. A growing body of evidence links lncRNA mutation and dysregulation to diverse diseases. However, the association lncRNAs with pathogenesis lung fibrosis remains poorly understood. In this study, we detected changes hydroxyproline collagen levels, as well ultrastructure tissue develop a rat model fibrosis. The differentially expressed mRNA profiles between fibrotic normal...
Quantifying the rates of soil evolution greatly benefits our understanding formation and management, especially in context strong anthropogenic activities climate change. This study investigated an artificial oasis region with a reclamation history more than 50 years, critical properties were measured at 77 sites. A total 462 samples collected down to depth 1 m. seven analysed, four (i.e., organic carbon (SOC), phosphorus (TP), pH, ammonium nitrogen (NH4+)), which not closely correlated each...
<title>Abstract</title> Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown etiology. Abnormal regulation the cytoskeleton key factor driving fibrogenesis. However, molecular mechanisms remodeling in remains obscure. Methods Succinylome analysis lung tissues from bleomycin (BLM)-treated mice was performed. Key modified proteins and sites were identified through Clusters Orthologous Groups (COG) functional classification...
Immunotherapy resistance is a significant obstacle in the treatment of prostate cancer (PCa), primarily due to immune evasion mechanisms. This study aims explore cancer-intrinsic evasion-related genes (CIERGs) PCa and develop predictive signature for biochemical recurrence (BCR). Bulk RNA-seq data single-cell RNA-sequencing (scRNA-seq) were obtained from TCGA Gene Expression Omnibus database. The scRNA-seq analysis revealed higher scores tumor cells compared normal cells. Differentially...
Quantifying changes in soil properties greatly benefits our understanding of management and sustainable land use, especially the context strong anthropogenic activities climate change. This study investigated effects long-term reclamation on an artificial oasis region with a cultivation history more than 50 years. Critical were measured at 77 sites, total 462 samples collected down to depth 1 m, which captures both surface subsurface processes that are critical for effects. Thirteen...
Photodynamic therapy (PDT) of cancer is a two-step drug-device combination modality, which involves the topical or systemic administration photosensitizer followed by light illumination site. In presence oxygen molecules, (PS) can lead to generation cytotoxic reactive species (ROS) and consequently destroy cancer. Similar many other anticancer therapies, PDT also subject intrinsic resistance mediated multidrug (MDR) mechanisms. This paper will review recent progress in understanding...
The lack of effective chemical tools capable dynamic tracking labile glyoxal species (GOS) [e.g., methylglyoxal (MGO) and (GO)] levels with high selectivity over other relevant electrophilic species, particularly, formaldehyde (FA) nitric oxide (NO), has significantly hampered the understanding their roles in a complex metabolic network disease progressions. Herein, we report rational design bioinspired 4-(2-guanidino)-1,8-naphthalimide fluorescent probes NAP-DCP-1 NAP-DCP-3 from...
Abstract Pulmonary fibrosis is a chronic interstitial lung disease characterized by pulmonary epithelial injury, fibroblast activation, extracellular matrix deposition, and tissue structure destruction. However, an effective drug treatment remains unavailable. Therefore, studying the mechanism of fibrogenesis finding drugs have become important problems in field respiratory diseases. typically activated proliferation migration. Hence, abnormality migration major concern for treating...
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare form of adrenal Cushing's syndrome. The slowly progressing expansion tissues usually persists for dozens years, leading to delayed onset with severe conditions due chronic mild hypercortisolism. About 20-50% cases were found be caused by inactivating mutation armadillo repeat-containing protein 5 (ARMC5) gene.
Hepatocellular carcinoma often metastasizes along the portal venous system, necessitating precise anatomical resection.Anatomic resection (AR) involving segments S6 and S7 aims to enhance oncological efficacy while preserving liver volume.The intersegmental veins (IVs) between these are potential landmarks that facilitate accurate determination of plane.Three-dimensional (3D) reconstruction technology was used analyze IVs in 164 patients who underwent contrast-enhanced computed tomography...
Precisely quantifying the adhesion energy of delicate nanobelts on rough substrates remains challenging due to their disparate surface properties and nanoscale dimensions. To overcome these challenges, we propose an optical microscopy-based bridging method quantify ZnS Si in air. Our results revealed that nanobelt–smooth substrate interfacial system exhibits enhanced electrostatic interactions between polar nanobelt surfaces polarized substrate. While, for nanobelt–rough system, values...
Acute interstitial pneumonia is a rare lung disease that rapidly progresses to respiratory failure or death. Several studies showed myofibroblast plays an important role in the evolution of diffuse alveolar damage, which typical feature acute pneumonia. However, no evidence exists whether epithelial cells are additional source myofibroblasts via epithelial-mesenchymal transition In this report, we present case previously healthy 28-year-old non-smoking woman. Chest high-resolution computed...
Pancreatic cancer is one of the most common fatal malignancies and has a poor prognosis. Surgical treatment important method, but there low rate radical excision; moreover, postoperative recurrence high, with local greater than 50%. The usefulness intraoperative radiotherapy for pancreatic previously been examined. However, prior research was based on traditional high-energy electron beam, which causes serious radiation toxicity. Therefore, tumor dose limited, subsequently limiting effect....
Abstract Background Portal vein tumor thrombus (PVTT) is common in hepatocellular carcinoma (HCC). Recent studies indicate that more aggressive treatments, including surgical resection or locoregional treatment, may benefit selected HCC patients with PVTT. External radiation therapy and infusion chemotherapy were found to achieve good outcomes; however, the use of low-energy x-ray system (INTRABEAM), intraoperative therapy, portal for PVTT has not been reported. Case summary We present a...
Background: Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy in humans. Although early-stage CCA can be managed with surgery, considered incurable at advanced stages and results poor quality of life overall survival. A good orthotopic animal model essential to perform basic studies investigating order understand molecular pathways that underlie cancer development, develop new therapies for prevention treatment CCA. However, best our knowledge, extrahepatic models...
Abstract The title compounds show selective cytotoxic effects on HL‐60 cell lines.