A5028732650- Crystallization and Solubility Studies
- Sulfur Compounds in Biology
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Selenium in Biological Systems
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Epilepsy research and treatment
- Crystallography and molecular interactions
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Redox biology and oxidative stress
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- Natural Products and Biological Research
- Heme Oxygenase-1 and Carbon Monoxide
Binzhou University
2015-2025
Binzhou Medical University
2015-2025
Soochow University
2012-2025
Second Affiliated Hospital of Soochow University
2015-2025
Wenzhou Medical University
2020-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Fujian Institute of Research on the Structure of Matter
2024
University of Chinese Academy of Sciences
2024
Shandong Normal University
2013-2022
Shanghai Jiao Tong University
2019-2021
A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed successfully applied to investigating the relationship between epithelial–mesenchymal transitions (EMTs) in tumour progression intracellular hypoxic level.
Chemotherapy is an important option for the treatment of various cancers including lung cancer. However, tumor resistance towards cytotoxic chemotherapy has become more common. It been reported that autophagy one processes contributing to this resistance. In present study, we found anti-cancer drug 5-fluorouraci(5-FU) could induce in A549 cells. 5-FU lead conversion LC3 I/II, up-regulation Beclin-1, down-regulation p62 and formation acidic vesicular organelles (AVOs) Pre-treatment cancer...
Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it unclear whether contributes to the onset of epilepsy or seizures. We sought investigate changes succinate, oxidative stress, mito-SOX levels, as well mitophagy change, different status epilepticus (SE) rat models. Our results demonstrate that KA-induced SE was accompanied by increased levels mito-SOX, degeneration. The similarly were also...
The first near-infrared fluorescent probe to detect H<sub>2</sub>Se with high sensitivity was explored in living cells and mice.
Rationale: Selenium has been shown to have chemotherapeutic effects against cancer.However, the anti-cancer mechanism of selenium is not fully understood, and role hydrogen selenide (H 2 Se), which a common metabolite dietary compounds, elucidated due lack detection methods.In this study, we revealed new selenite with help H Se fluorescent probe.Methods: HepG2 cells were cultured under simulated tumor hypoxic microenvironment.The O levels detected by probes in living mice.Autophagic...
An ultrasensitive fluorescent probe for monitoring NAD(P)H and revealing reductive stress induced by natural antioxidants in HepG2 cells under hypoxia.
A novel viscosity probe (NV1) was developed for assessing cancer cell migration. NV1 can respond to changes of rapidly and exhibits high sensitivity in HepG2 cells treated with starvation, rotenone nystatin. Importantly, used the first time evaluate relationship between intracellular migration proved that increased inhibits while decreased promotes
In order to investigate the Na<sub>2</sub>SeO<sub>3</sub>anticancer mechanism in HepG2 cells, a novel selenol fluorescence probe has been designed and used image selenocysteine (Sec) living cells and<italic>in vivo.</italic>
Hydrogen selenide (H2Se) is an important metabolite of dietary Se compounds and has been implicated in various pathological physiological processes. The development highly sensitive selective methods for the sensing H2Se therefore very important. Herein, we developed a fluorescent probe (hemicyanine (Hcy)-H2Se) detecting based on new H2Se-specific receptor unit, 1,2-dithiane-4,5-diol. Hcy-H2Se showed high selectivity toward over thiols (RSH), hydrogen sulfide (H2S), selenocysteine (Sec) was...
The engineering of pharmaceutical cocrystals has been effectively utilized to improve the physicochemical properties such as stability and solubility, thus it could optimize solid formations active ingredients. This work focuses on sulfamethazine–p-aminobenzoic acid (STH–PABA) cocrystal regulated by molecular synthons constructed from mutual N···H···O interactions. STH–PABA was produced means slow evaporation crystallization method, structure determined through X-ray crystallography....
The purpose of this study was to investigate the expression autophagy-related proteins Beclin 1 and LC3 in cervical normal epithelial cells squamous cancer cells, evaluate prognostic significance FIGO stage I-II cell carcinoma. immunohistochemical were evaluated 26 formalin-fixed paraffin-embedded tissue samples 50 tumor carcinoma, respectively. Correlations with clinicopathologic characteristics determined by Chi-square test. impact regard overall survival Kaplan-Meier method. Cervical...
Peniciketals A–C (1–3), three new spiroketals with a benzo-fused 2,8-dioxabicyclo[3.3.1]nonane moiety, were isolated from the saline soil derived fungus Penicillium raistrichii. Their structures including absolute configurations established by NMR, X-ray diffraction, and ECD calculations. cytotoxicities tested against A549, HL-60, K562 cell lines, 1–3 showed selective effects on HL-60 cells IC50 values of 3.2, 6.7, 4.5 μM, respectively.
Abstract Diabetic vascular complications are closely associated with long‐term dysfunction and poor neovascularization. Endothelial progenitor cells (EPCs) play pivotal roles in maintaining homeostasis triggering angiogenesis, EPC contributes to defective angiogenesis resultant diabetic complications. Fibroblast growth factor 21 (FGF21) has received substantial attention as a potential therapeutic agent for diabetes via regulating glucose lipid metabolism. However, the effects of FGF21 on...
Protopanaxadiol (PPD) has potential immunomodulatory effects, but the underlying mechanism remains unclear. Here, we explored roles of gut microbiota in immunity regulation mechanisms PPD using a cyclophosphamide (CTX)-induced immunosuppression mouse model. Our results showed that medium dose (PPD-M, 50 mg/kg) effectively ameliorated induced by CTX treatment promoting bone marrow hematopoiesis, increasing number splenic T lymphocytes and regulating secretion serum immunoglobulins cytokines....
The purpose of this research is to further the understanding crystalline amorphous phase transition (amorphization) that occurs when some drugs are dry blended with porous adsorbents. Indomethacin (IMC) and three grades silica gel (SGs) were used in study. Amorphization IMC rapidly during mixing SG was independent intensity time. Extent amorphization increases lower ratios IMC:SG decreased particle size. Blocking H-bonding silanol groups on by chemical modification reduced extent...