Atherosclerosis is characterized by the accumulation of lipids within arterial wall. Although activation TRPV1 cation channels capsaicin may reduce lipid storage and formation atherosclerotic lesions, a clinical use for has been limited its chronic toxicity. Here we show that coupling copper sulfide (CuS) nanoparticles to antibodies targeting act as photothermal switch signaling in vascular smooth muscle cells (VSMCs) using near-infrared light. Upon irradiation, local increases temperature...

Alterations of cellular redox status are closely associated with physiological and pathological processes. Glutathione (GSH) H2O2 should be the most representative couple in living cells. However, up to now, there is no way reversibly detect GSH/H2O2. In this report, a near-infrared (NIR) fluorescent probe (Cy-O-Eb) for monitoring changes GSH/H2O2 levels vivo was developed based on switching on–off five-membered ring involved ebselen. This could respond GSH high selectivity, sensitivity...

Abstract Gold nanoparticles (Au NPs) assembled through Au−S covalent bonds have been widely used in biomolecule‐sensing technologies. However, during the process, detection distortions caused by high levels of thiol compounds can still significantly influence result and this problem has not really solved. Based on higher stability Au−Se compared to bonds, we prepared selenol‐modified Au NPs as an Au‐Se nanoplatform (NPF). Compared with Au‐S NPF, NPF exhibits excellent anti‐interference...

We have developed a new fluorescent and photoacoustic dual-mode probe, ER-P, for the detection of ER polarity liver tissues in normal diabetic mice.

Compared with semiconductor quantum dots and organic chromophores, carbon (CDs)-based lysosome probe strong emission, an intrinsic targeting ability, easy synthesis procedure were urgently desired in visualization imaging studies. Herein, we showed that it was possible to produce CDs the properties for via a one-step hydrothermal treatment of commercial reagents, rose bengal (RB) branched polyethylenimine (bPEI). The prepared bPEI-RB (P-R CDs) had high fluorescence yield (FLQY) 90.49%,...

Inflammation triggered by oxidative stress is the main determinant of atherosclerotic plaque disruption, which leading cause myocardial infarctions and strokes. Hence, noninvasive mapping alterations in redox status vivo highly desirable for accurate assessment inflammatory activity vulnerability. Herein, two types near-infrared fluorescence probes, specific glutathione (GSH)/hydrogen peroxide (H2O2) couple, were used to introduce self-assembly bovine serum albumin (BSA), forming a...

In this paper, we have developed a biofriendly and high sensitive apo-GOx (inactive form of glucose oxidase)-modified gold nanoprobe for quantitative analysis imaging consumption in living cells. This detection system is based on fluorescence resonance energy transfer between modified AuNPs (Au nanoparticles) dextran-FITC (dextran labeled with fluorescein isothiocyanate). Once present, quenched FITC recovers due to the higher affinity over dextran. The shows excellent selectivity toward...

Messenger RNA (mRNA)-based vaccines have enormous potential in infectious disease prevention and tumor neoantigen application. However, developing an advanced delivery system for efficient mRNA intracellular release protein translation remains a challenge. Herein, biocompatible biomimetic is designed using red blood cell-derived nanoerythrosomes (NER) black phosphorus nanosheets (BP) delivery. BP covalently modified with polyethyleneimine (PEI), serving as core to efficiently condense via...

A copper(i)-mediated carboamination cascade reaction between vinyl azides and aryldiazonium salts is described. Functionally diverse N2-substituted 1,2,3-triazoles were obtained in moderate to good yields through novel difunctionalization of by salt sources. This method has a wide scope, functional-group tolerance insensitivity an ambient atmosphere.

A competitive coordination-based hydrogen peroxide (H2O2) nanosensor is constructed by the assembly of FAM-tagged single-strand (ss) DNA on cerium oxide nanowires (CeO2 NWs). This fluorescent capable rapidly and selectively tracking H2O2 within living cells, as well directly visualizing generated wound-induced oxidative damage in zebrafish larvae.

A H₂O₂-responsive and plaque-penetrating S2P–CeO₂–ASOs nanoplatform was developed for the effective silencing of mTOR treatment atherosclerosis.

MicroRNA-155 (miR-155), which facilitates breast tumor growth and invasion by promoting cell proliferation inhibiting apoptosis, is considered an ideal early diagnostic prognostic marker. Herein, we developed a self-assembled hybridization chain reaction (HCR)-based photoacoustic (PA) nanoprobe for highly sensitive in situ monitoring of dynamic changes miR-155 expression during tumorigenesis chemotherapy. The PA nanoprobes (Au-H1/PEG Au-H2/PEG) were constructed linking poly(ethylene glycol)...

We have developed multifunctional Au–ZnO hybrid nanoparticles (NPs) for targeted induction lysosomal membrane permeabilization (LMP)-dependent apoptosis in cancer cells and real-time imaging.

Atherosclerotic plaque calcification is an oxidative-stress-dependent process involved in the onset of disruption and subsequent atherothrombotic events. Excessive reactive oxygen species (ROS) production determines structural modification protein cysteine sulfhydryl (Cys-SH), leading to alteration functions redox signaling outputs. Although these redox-centered pathways have been found play important roles calcification, extent Cys-SH modifications regulatory regions specific proteins...

A novel and direct disulfonylation reaction of commercially available terminal alkynes under copper(I)/bromodifluoroacetate cocatalyst has been realized. This protocol provides a facile practical pathway to selectively access (E)-1,2-disulfonylethenes, in which features good functional group compatibility, easily starting materials, excellent stereoselectivity with yields.

Glycosylation is a key cellular mechanism that regulates several physiological and pathological functions. Therefore, identification characterization of specific-protein glycosylation in vivo are highly desirable for studying glycosylation-related pathology developing personalized theranostic modalities. Herein, we demonstrated photoacoustic (PA) nanoprobe based on the proximity-induced hybridization chain reaction (HCR) amplified visual detection protein-specific vivo. Two kinds functional...

Cysteine sulfonic acid, a product of protein oxidative damage, is an important sign by which the body and cells sense stress. Cigarette smoke (CS) can trigger inflammatory reactions in humans that lead to higher levels stress reactive oxygen species (ROS) body. Available evidence indicates possible relationship between damage cigarette smoke, poorly understood due limitations analytical techniques. Herein, we developed donor–acceptor structured aggregation-induced emission (AIE) fluorescence...