A5102743602- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Plant Gene Expression Analysis
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Plant and Fungal Species Descriptions
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Plant and animal studies
- Lipid metabolism and biosynthesis
- Muscle and Compartmental Disorders
- Plant Diversity and Evolution
- RNA modifications and cancer
- Biological and pharmacological studies of plants
- Pediatric Pain Management Techniques
- Nausea and vomiting management
- RNA Research and Splicing
- Plant Reproductive Biology
- Erythrocyte Function and Pathophysiology
Fujian Agriculture and Forestry University
2018-2025
Shanghai Sixth People's Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Hangzhou First People's Hospital
2025
Westlake University
2025
Integrated Chinese Medicine (China)
2025
Second Affiliated Hospital of Zhejiang University
2025
Beijing Academy of Artificial Intelligence
2024-2025
Xi'an Jiaotong University
2024
Wenzhou Medical University
2015-2023
Acute kidney injury (AKI) progression to chronic disease (CKD) represents a unique renal setting characterized by early cellular and regulated cell death, later fibrosis, of which the critical role nature ferroptosis are only partially understood. Here, we report that tubular epithelial caused HDAC3 (histone deacetylase 3) aberration resultant GPX4 suppression drives AKI-CKD progression. In mouse models transition induced nephrotoxic aristolochic acid (AA) folic (FA), occurred coincided with...
The MADS-box transcription factor gene family is essential for the differentiation and development of floral organs. Genome-wide transcriptome data from Phoebe bournei provide foundation studying its development. In this study, phylogenetic relationships, protein characteristics, conserved domains, structures, cis-acting elements in promoter regions P. genes were systematically analyzed through bioinformatics methodologies. A total 69 PbMADS identified classified into 15 subfamilies based on...
Abstract Bone loss and increased fracture are the devastating outcomes of chronic kidney disease-mineral bone disorder (CKD-MBD) resulting from Klotho deficit-related mineral disturbance hyperparathyroidism. Because down-regulation after renal injury is presumably affected by aberrant histone deacetylase (HDAC) activities, here we assess whether HDAC inhibition prevents attenuates CKD-associated complication in a mouse model CKD-MBD. Mice fed adenine-containing diet developed expected...
In response to biotic and abiotic stresses, the WRKY gene family plays a crucial role in plant growth development. This study focused on
The aim of this study was to investigate the roles cyclin D1, CDK4, and p53 in knee osteoarthritis (KOA).A total 76 healthy controls 154 KOA cases (grades ranging from II IV) were recruited. Protein expression detected by immunohistochemistry, mRNA levels genes measured reverse transcription-polymerase chain reaction.Both protein D1 CDK4 significantly lower than those controls, while higher that (all p < 0.05). As grades increased, Cyclin expressions decreased, whereas increased In cases,...
Abstract This study aims to explore the effects of miR‐539 on osteoblast proliferation and differentiation osteoclast apoptosis in a rat model osteoporosis, its mechanism involving regulation AXIN1‐mediated wingless‐Int (Wnt) signaling pathway. A osteoporosis was successfully established by ovariectomy. With osteoblasts osteoclasts rats not receiving ovariectomy sham group as control, those osteoporotic were treated with inhibitor, mimic, AXIN1 shRNA. The expression miR‐53, AXIN1, Wnt...
Abnormal Wnt5a expression, mitochondrial abnormalities and calcium overload have been detected in many metabolic diseases. However, the association of Wnt5a-Ca2+ dysfunction diabetic nephropathy (DN) progression remains unknown. We used streptozotocin-induced DBA2/J male mice as a DN model. The were treated with losartan (10 mg/kg/d*12 w) or + levamlodipine (5 w). High glucose (HG) (40 mmol/L)-induced HK-2 cells for vitro experiments. uniporter (MCU) dynamics, morphological changes Ca2+...
<title>Abstract</title> RNA plays multifaceted roles in catalytic reactions and gene regulation. The sequence-encoded binding language across diverse RNA-target interactomes is high-dimensional complex. Here, we introduce UltraGen, an model designed to capture properties. Utilizing fine-grained self-learning, UltraGen identifies aptamers for a wide range of target sizes, including small molecules, proteins, cells, tissues. Additionally, discerns tissue specificity millions species 22 human...
The Fagaceae family, comprising over 900 species, is an essential component of Northern Hemisphere forest ecosystems. However, genomic data for tropical and subtropical genera Castanopsis Castanea remain limited compared to the well-studied oak. Here, we present chromosome-level genome assemblies carlesii henryi, with assembled sizes 927.24 Mb (N50 = 1.57 Mb) 780.10 1.07 Mb), respectively, repetitive sequence contents 45.79% 44.88%. Comparative analysis revealed that estimated divergence...
Renal ischemia reperfusion injury (IRI) has become a growing concern in clinical practice with high morbidity and mortality rates. There is currently no effective prophylactic regimen available to prevent its occurrence improve prognosis. Dl-3-n-butylphthalide (NBP) been used for stroke treatment China years. Little known about role preventing kidney injury. The kidneys of male C57BL/6J mice were subjected 33 min followed by 24 h reperfusion. NBP was administered gavage prior surgery....
Chemoresistance implicates the therapeutic value of cisplatin and remains a primary obstacle to its clinical use. MicroRNAs (miRs) negatively modulate expression their target genes are associated with occurrence progression various types tumor. The abnormal miR‑504 has been reported in certain human tumor prognosis. However, association between osteosarcoma unclear. present study therefore aimed assess vitro effects possible mechanism cell proliferation, apoptosis resistance MG63 cells....
This study is aimed to investigate the effectiveness of 4 allergic rhinitis (AR) drugs (loratadine, cetirizine, montelukast, and desloratadine) in reducing functional problems patients, as indicated by rhinoconjunctivitis quality life questionnaire scores. After an exhaustive search electronic databases containing published scientific literature, high-quality randomized controlled trials relevant our were selected based on a stringent predefined inclusion exclusion criteria. Statistical...
Previous research has reported that salidroside exerts antitumor properties on numerous types of tumor cells; however, its effect osteosarcoma cells remains unknown. The present study aimed to investigate the effects viability, apoptosis and invasion in vitro, determine underlying mechanism action. results an MTT revealed suppressed viability (MG63 U2OS cells) a time‑ concentration‑dependent manner. cell morphological analysis (profile observations Hoechst 33258 staining) detection by flow...