A5081963035- Respiratory Support and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA regulation and disease
- Cholinesterase and Neurodegenerative Diseases
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Antifungal resistance and susceptibility
- Epilepsy research and treatment
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- Pharmacogenetics and Drug Metabolism
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
Henan Provincial People's Hospital
2019-2024
Zhengzhou University
2020-2024
Henan University
2024
This study aimed to investigate the effect of long noncoding ribonucleic acids (RNAs) metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) on regulating neuron apoptosis, neurite outgrowth and inflammation, further explore its molecule mechanism in Alzheimer's disease (AD).Control overexpression, lnc-MALAT1 control shRNA, shRNA were transfected into NGF-stimulated PC12 cellular AD model from primary cerebral cortex neurons rat embryo, which established by Aβ1-42 insult. Rescue...
: Neutrophil elastase has been identified as a potential therapeutic target for acute lung injury or respiratory distress syndrome, and Sivelestat is selective, reversible competitive neutrophil inhibitor. This study was designed to investigate the safety, tolerability, pharmacokinetics inhibitory effects of in healthy Chinese subjects. A randomized, double-blind, placebo-controlled single- multiple-dose escalation clinical trial carried out. Briefly, volunteers twelve cohorts with 8 per...
1. Polymorphisms of cytochrome P450 2C19 (CYP2C19) is an important factor contributing to variability voriconazole pharmacokinetics. CYP3A4, CYP3A5, CYP2C9 and non-genetic factors such as age, gender, body mass index (BMI), transaminase levels, concomitant medications might also affect initial steady serum trough concentration (VICmin) in haematological patients, but the effects were not clear. 2. Eighteen single-nucleotide polymorphisms CYP2C19, genotyped. Patients stratified into two...