A5010082489- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Enzyme Structure and Function
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Herpesvirus Infections and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- bioluminescence and chemiluminescence research
- Tryptophan and brain disorders
- Analytical Chemistry and Chromatography
- Genomics and Chromatin Dynamics
- RNA regulation and disease
- GDF15 and Related Biomarkers
- Microfluidic and Capillary Electrophoresis Applications
- Thyroid Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Genetic Syndromes and Imprinting
- Spinal Cord Injury Research
- Glutathione Transferases and Polymorphisms
Tongren Hospital
2022-2025
Liaoning Cancer Hospital & Institute
2023-2025
China Medical University
2023-2025
Zhengzhou University
2020-2024
Henan Provincial People's Hospital
2019-2024
Shanghai Jiao Tong University
2009-2024
VA Palo Alto Health Care System
2015-2023
Stanford University
2013-2023
Henan University
2020-2023
Shanghai First People's Hospital
2013-2018
Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences lncRNA inactivation in vivo mostly unknown. Here, we show that targeted deletion mouse Hotair leads derepression hundreds genes, resulting homeotic transformation spine and malformation metacarpal-carpal bones. RNA sequencing conditional reveal an ongoing requirement repress HoxD genes several imprinted loci such as Dlk1-Meg3 Igf2-H19 without affecting imprinting choice. binds both...
In an immune response, CD4+ T cells expand into effector and then contract to survive as long-lived memory cells. To identify age-associated defects in cell formation, we profiled activated found increased induction of the ATPase CD39 with age. CD39+ resembled signs metabolic stress high susceptibility undergo apoptosis. Pharmacological inhibition activity dampened differentiation improved survival, suggesting that influences fate. Individuals carrying a low-expressing variant responded...
This study aimed to investigate the effect of long noncoding ribonucleic acids (RNAs) metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) on regulating neuron apoptosis, neurite outgrowth and inflammation, further explore its molecule mechanism in Alzheimer's disease (AD).Control overexpression, lnc-MALAT1 control shRNA, shRNA were transfected into NGF-stimulated PC12 cellular AD model from primary cerebral cortex neurons rat embryo, which established by Aβ1-42 insult. Rescue...
Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ cells, suggesting mechanisms that preferentially protect during aging. Here, we show TRIB2 is abundant in and counteracts quiescence exit by suppressing AKT activation. deficiency increases activity accelerates proliferation differentiation response interleukin-7 (IL-7) humans lymphopenia mice. transcription controlled the lineage-determining factors ThPOK RUNX3. Ablation of Zbtb7b (encoding ThPOK) Cbfb (obligatory...
Abstract Significant progress in the application of immune checkpoint blockade (ICB) for treatment multiple types cancers has been achieved, but its overall response rate and therapeutic efficacy remain unsatisfactory. To address these limitations, identification a combinational approach to enhance ICB is needed. The activation cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) signaling critical induction antitumor innate responses promising target development immunotherapy....
Interleukin (IL)-17 plays a key role in immunity. In acute infections, rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial producers. fact, some make within hours after an immune challenge. These appear to acquire ability respond IL-1 IL-23 naturally naïve animals. They known as natural Tγδ17 (nTγδ17) cells. The rapidity of nTγδ17 response, apparent lack explicit cell receptor (TCR) engagement for its induction have led view that this is...
Memory T cells exhibit considerable diversity that determines their ability to be protective. Here, we examine whether changes in cell heterogeneity contribute the age-associated failure of immune memory. By screening for age-dependent cell-surface markers, identify CD4 and CD8 memory subsets are unrelated previously defined central effector cells. expressing ecto-5'-nucleotidase CD73 constitute a functionally distinct subset declines with age. They resemble long-lived, polyfunctional but...
Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization strategies are insufficient with increasing age due to immunological impediments, including defects T follicular helper (Tfh) cells. Here, we found that Tfh generation inversely linked the expression of ecto-NTPDase CD39 modifies purinergic signaling. The lineage-determining transcription factor BCL6...
ABSTRACT A city-wide cytomegalovirus serosurvey was conducted in Shanghai, China, and associated parameters were calculated by employing the catalytic model. The lowest seroprevalence 60.37%, found >1- to 3-year age group. value increased rapidly with until 25 years, when a of 97.03% found, caused high force infection (12.69) reproductive rate (8.89).
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression severity treatment response in colorectal cancer (CRC).Our sample size consisted of 139 CRC patients who were treated with surgery alone.Immunohistochemistry was used to investigate prognostic significance CRC, while weak normal tissue as basis for assessing tumors (control group).Real-time reverse transcription-polymerase chain reaction quantified miR-30a levels.The levels associated clinical variables...
Unaffordable medical treatment and inflated drug prices have become a challenging issue for lawmakers worldwide. To reduce the financial burden standardize pharmaceutical market, Chinese government has issued several detailed regulations, including measures of recruitment procurement in one volume purchasing to not only ensure high quality approved drugs but also lower cost production sell procedure. In this work, thorough overview enforcement these we attempted critically analyze data our...
Microangiopathy is a major cause in diabetic polyneuropathy (DPN). This review examines evidence from both human and animal studies to elucidate the important microvascular factors DPN.This literature of articles published on PubMed English.There an abundance linking endoneurial abnormalities peripheral nerve dysfunction pathology patients with diabetes. These structural changes result abnormal diffusion barrier leading hypoxia. Furthermore, functional microvessels characterized by reduced...
The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development contributes to exhaustion, thereby causing defective tumor immunity deficient responses older adults who have increased expression. Tuning enzymatic activity targeting transcriptional regulation ENTPD1 can be used modulate signaling. Here, we describe that STAT6 phosphorylation downstream IL-4...
Lateral Lymph Node Metastasis (LLNM) is common in Papillary Thyroid Carcinoma (PTC) and associated with a poor prognosis. LLNM without central lymph node metastasis as skip not common. We aimed to investigate clinicopathologic sonographic risk factors for PTC patients, establish nomogram predicting the possibility of order determine therapeutic strategy. retrospectively reviewed data 1037 patients who underwent surgery from 2016 2020 at single institution. Univariate multivariate analyses...