A5063300564- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA modifications and cancer
- Pediatric Pain Management Techniques
- Pain Management and Placebo Effect
- Cancer-related molecular mechanisms research
- Pain Management and Treatment
- Anesthesia and Pain Management
- Mycobacterium research and diagnosis
- Pain Management and Opioid Use
- Cancer, Stress, Anesthesia, and Immune Response
- Nerve Injury and Rehabilitation
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Tribology and Lubrication Engineering
- Phytoestrogen effects and research
- Thyroid and Parathyroid Surgery
- Heart Failure Treatment and Management
- Renal and related cancers
- Renal and Vascular Pathologies
- Mechanical stress and fatigue analysis
- Liver Disease and Transplantation
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
Shanxi University
2025
Liaoning Cancer Hospital & Institute
2011-2025
Lushang (China)
2025
China Medical University
2017-2024
Xuzhou Central Hospital
2024
Dalian University of Technology
2023
First Hospital of China Medical University
2012
Northeastern University
2010
Our study was intended to provide evidence for whether long noncoding RNA (lncRNA) SNHG1 would accelerate the epithelial-mesenchymal transition (EMT) course intrinsic in colorectal cancer (CRC) by sponging downstream miR-497-5p and miR-195-5p. We altogether collected 338 pairs of CRC noncancerous tissues, meanwhile purchased five cell lines (i.e., SW480, HCT116, Lovo, CaCO-2, HT29) human embryo intestinal mucosal tissue-sourced line CCC-HIE-2). The cells as mentioned above were appraised...
MiR-30 family plays an important role in the tumorigenesis of human cancers. The aim study is to investigate miR-30d colon cancer cell lines and explore molecular mechanism proliferation cells. expression was determined by real-time polymerase chain reaction assay (HCT15, HCT116, HT-29, DLD-1, SW480) results demonstrated that level significantly decreased lines, compared with normal epithelial line. Transfection mimics inhibited proliferation, transfection inhibitors promoted viability...
MicroRNAs have been proved to participate in multiple biological processes cancers. For developing resistance cytotoxic drug, cancer cells, especially the stem usually change their microRNA expression profile survive hostile environments. In present study, we found that of microRNA-27a was increased colorectal cells. High level indicated induce TNF-related apoptosis-inducing ligand (TRAIL). Knockdown resensitized cells TRAIL-induced cell death. Mechanically, gene Apaf-1, which is associated...
The use of black soybean (Glycine max L.), an edible crop prevalent in Asia, has attracted attention for its hepatoprotective properties. Notably, the anthocyanin components coats have shown potential inhibiting tumor growth. Here, anthocyanins were extracted from using both microwave and water bath methods. physicochemical characteristics coat (BSCAs) their biological activities examined. results MTT EDU assays demonstrated a dose-dependent inhibitory effect BSCAs on hepatocellular...
Abstract Diffuse Large B-Cell Lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma with heterogeneous molecular characteristics. Altered metabolism, particularly mitochondrial function, has emerged as a critical factor in cancer progression. However, the role metabolism DLBCL remains poorly understood. This study aimed to identify key factors associated We analyzed transcriptomic data from multiple datasets (GSE83632, TCGA–GTEX, GSE181063, GSE4475) using differential expression...
e16022 Background: Anti-PD-1 in combination with chemotherapy has been confirmed to improve the prognosis of patients advanced gastric/gastroesophageal junction (G/GEJ) cancer, particularly those a PD-L1 combined positive score (CPS) ≥5. However, efficacy and safety continuing immune-based therapy after disease progression (PD) who have benefited from first-line immunochemotherapy remain unclear. We conducted two-stage, phase 2 trial explore clinical feasibility serplulimab (an anti-PD-1...
Lateral Lymph Node Metastasis (LLNM) is common in Papillary Thyroid Carcinoma (PTC) and associated with a poor prognosis. LLNM without central lymph node metastasis as skip not common. We aimed to investigate clinicopathologic sonographic risk factors for PTC patients, establish nomogram predicting the possibility of order determine therapeutic strategy. retrospectively reviewed data 1037 patients who underwent surgery from 2016 2020 at single institution. Univariate multivariate analyses...
A hybrid drug delivery system (DDS) composed of hyaluronan and calcium carbonate (CC) was developed. By taking advantage the tumor-targeting ability drug-loading property CC, well-formed hyaluronan–CC nanoparticles were able to serve as a DDS targeting colorectal cancer with decent loading content, which is beneficial in chemotherapy cancer. In this study, smaller than 100 nm successfully developed load wide-range anti-cancer adriamycin (Adr) construct hyaluronan–CC/Adr nanoparticles. On...
Tohoku J. Exp. Med., 227: 225-230, 2012.In the version of this article published in July issue, 2012, lettering ‘β-action' is a misprint for ‘GAPDH' panel A Figure 2 (pages 228).
Altered glucose metabolism has been found in a variety of malignant diseases and recognized as one the hallmarks cancer. However, molecular mechanism behind it is far from well understood. In current study, we silencer death domains (SODD) regulates uptake colorectal cancer cells. When cultured under low level glucose, SODD overexpressing RKO SW1417 cells generated more colonies, compared with control cells, clonogenic assay. upregulation enhanced viability. Furthermore, induced GLUT1...
Recent studies have proved the diverse roles of miRs in different cancer-related processes. This study was undertaken to determine therapeutic implications miR-325-3p breast cancer.Expression analysis carried out by qRT-PCR. Transfections were performed Lipofectamine 2000 reagent. MTT assay used for cell viability. Transwell assays migration and invasion. Western blot protein expression analysis.Gene revealed miR-325 be significantly suppressed cancer tissues lines. Nonetheless, ectopic...
<title>Abstract</title> <bold>Background</bold>Breakthrough cancer pain (BTcP) has a negative impact on patients’ quality of life, general activities, and is related to worse clinical outcomes. Fentanyl inhalant hand-held combination drug-device delivery system providing rapid, multi-dose (25μg/dose) administration fentanyl via inhalation thermally generated aerosol. This multicenter, randomized, placebo-controlled, multiple-crossover, double-blind study evaluated the efficacy, safety,...
Abstract Objective: To explore the method and short-term efficacy of cryoablation combined with hyperthermia (CCH) for patients unresectable pancreatic cancer. Methods: The study recruited 22 cancer diagnosed by a multidisciplinary team (MDT) at Liaoning Cancer Hospital from February 2023 to December 2023. We explored treatment procedure evaluated CCH therapy. examination characteristics before after surgery were compared, effectiveness open versus laparoscopic approach was evaluated....
e24058 Background: Breakthrough cancer pain (BTcP) can significantly impact the life quality of patient. Wide-used rapid-onset opioids (ROOs) for BTcP are transmucosal fentanyl-based preparations. Inhaled fentanyl demonstrated similar pharmacokinetic properties as intravenous administration in healthy volunteers. Fentanyl aerosol be generated via hand-held drug-device delivery system, providing rapid, consistent multi-dose administration. inhalant was explored alternative treatment patients...
Objective To study the effects of different positive end-expiratory pressure (PEEP) levels on heart function patients undergoing mechanical ventilation (MV) with echocardiography. Methods Thirty-six critical respiratory failure MVwere divided into two groups according to cardiac index (CI). The left was measured echocardiography at PEEP (0, 4, 7, 10, 14 cm H2O, 1cm H2O = 0. 098 kPa). Results In normal group (CI≥2. 0 L · min-1 m-2, n=17), an increase in had no significant ventricular systolic...
Background: Ventricular tachycardia (VT) is a life-threatening heart condition commonly seen in patients with myocardial infarction (MI). Although personalized computational modeling has been used to understand VT and its treatment noninvasively, this approach can be computationally intensive time consuming. Therefore, finding balance between mesh size efficiency important. This study aimed find an optimal resolution that minimizes the need for resources while maintaining numerical accuracy...