A5100331878- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Cancer Research and Treatments
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Lung Cancer Research Studies
- Phytochemistry and biological activity of medicinal plants
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Carbohydrate Chemistry and Synthesis
- Dietary Effects on Health
- Kruppel-like factors research
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
Peking University
2006-2025
China Agricultural University
2017-2025
Xi'an Jiaotong University
2022-2025
Xianning Central Hospital
2022-2025
Hubei University of Science and Technology
2025
State Forestry and Grassland Administration
2025
Kunming Medical University
2014-2024
Jinan Military General Hospital
2014-2024
Xiangya Hospital Central South University
2021-2024
Central South University
2021-2024
Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic response. Under normoxic conditions, HIF-1α recognized by von Hippel-Lindau tumor-suppressor protein (VHL), component an E3 ubiquitin ligase complex. This interaction thereby promotes rapid degradation HIF-1α. stabilized. We have previously shown that VHL binds in hypoxia-sensitive manner to 27-aa segment HIF-1α, and this regulation depends on posttranslational modification Through combination vivo...
Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here, we assessed whether one specific isoform, PKC-theta, was expressed critical CNS regions that regulate energy balance and it mediated the deleterious effects diets high fat, specifically palmitic acid, on hypothalamic insulin activity rats mice. Using a combination situ hybridization immunohistochemistry, found PKC-theta discrete neuronal populations arcuate nucleus, neuropeptide Y/agouti-related...
Aberrant glucose metabolism is one of the hallmarks cancer that facilitates cell survival and proliferation. Here, we demonstrate MUC1, a large, type I transmembrane protein overexpressed in several carcinomas including pancreatic adenocarcinoma, modulates to facilitate growth properties cells. MUC1 occupies promoter elements multiple genes directly involved regulates their expression. Furthermore, expression enhances glycolytic activity We also vivo uptake orthotopic implantation models...
Whether changes in endothelial tight junctions (TJs) lead to the formation of thoracic aortic aneurysm and dissection (TAAD) serve as an early indicator therapeutic target remains elusive.Single-cell RNA sequencing analysis showed aberrant TJ expressions aortas patients with TAAD. In a β-aminopropionitrile (BAPN)-induced TAAD mouse model, function was disrupted at stage (5 10 days) observed by vascular permeability assay, while intercellular distribution crucial components significantly...
The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset CX3CR1+ macrophages mainly located intima roots and ascending aortas Fbn1C1041G/+ mice, further validated MFS patients. Specific elimination cells by diphtheria toxin Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice efficiently ameliorated...
Objective— microRNA-155 (miR155) plays a critical role in immunity and macrophage inflammation. We aim to investigate the of miR155 atherogenesis. Approach Results— Quantitative real-time polymerase chain reaction showed that was expressed mouse human atherosclerotic lesions. expression macrophages correlated positively with proinflammatory cytokine expression. Lentivirus-mediated overexpression enhanced their inflammatory response lipopolysaccharide through targeting suppressor signaling-1...
Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at early onset pathology aortic aneurysms. Exploring key regulators that are responsible for maintaining contractile phenotype (VSMCs) may confer homeostasis and prevent aneurysmal disease. XBP1 (X-box binding protein 1), which exists in a transcriptionally inactive unspliced form (XBP1u) spliced active (XBP1s), is component response to endoplasmic reticular stress. Compared with XBP1s, little...
Immune cells in tumor microenvironment play a prominent role progression and metastasis. MicroRNA-155 (miR-155) represents an important player innate adaptive immunity by regulating differentiation, maturation activation of macrophages, dendritic cells, B T cells. However, the miR-155 expression immune solid development is less elucidated. Our current study showed that both B16-F10 melanoma Lewis lung carcinoma tumors grew much faster bic/miR-155 knockout (miR-155(-/-) ) mice along with...
Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis a variety diseases during early stage. Recent studies indicate metabolic reprogramming may be involved in VSMC phenotypic transition. However, definite molecules that link energy metabolism to distinct phenotype remain elusive.A carotid artery injury model was used study postinjury neointima formation as well vivo. RNA-seq analysis, cell migration assay, collagen gel contraction wire myography...
Abdominal aortic aneurysm (AAA) is a lethal cardiovascular disease, and there no proven drug treatment for this condition. In study, by using the Connectivity Map (CMap) approach, we explored naringenin, naturally occurring citrus flavonoid, as putative agent inhibiting AAA. We then validated prediction with two independent mouse models of AAA, calcium phosphate (CaPO4)-induced C57BL/6J mice angiotensin II-infused ApoE-/- mice. Naringenin effectively blocked formation AAAs progression...
Parental vaccine hesitancy is a major obstacle to childhood vaccination. We examined parental socioeconomic status (SES) disparities in hesitancy, and the potential mediating roles of perceived social support health literacy. A questionnaire survey was given parents with children aged below 6 years from six provinces China. SES by educational attainment, annual household income, subjective measure (using scale 1–10). Linear regression applied assess association between hesitancy....
The aim of the present study was to investigate effect hydrogen sulfide (H(2)S) signaling by nitric oxide (NO) in isolated rat aortas and cultured human umbilical vein endothelial cells (HUVECs). Both administration H(2)S NaHS, as well endogenous H(2)S, reduced NO formation, synthase (eNOS) activity, eNOS transcript abundance, l-arginine (l-Arg) transport (all P < 0.01). kinetics analysis activity l-Arg showed that V(max) values 0.01) without modifying K(m) parameters. Use selective NOS...
Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity mortality. XBP1 (X-box binding protein 1), existing as the XBP1u (unspliced XBP1) XBP1s (spliced forms, key component of endoplasmic reticulum stress involved vascular diseases. However, whether participates development remains unclear.We aim investigate role calcification. levels were reduced high phosphate-induced calcified smooth muscle cells, aortas from mice...
The mechanism of action cisplatin as a chemotherapeutic agent has been attributed to DNA binding, while its nephrotoxin is unresolved. Only approximately 1% intracellular interacts with DNA, primarily forming intrastrand cross-linked adducts, and many studies have implicated both nuclear cytoplasmic causes cisplatin-induced death in cultured cells. We demonstrated that cytotoxicity depends on cdk2 activity, which at least partly through the cdk2-E2F1 pathway. dependency cdk2, whether...
While myeloid‐derived suppressor cells (MDSCs) have been reported to participate in the promotion of angiogenesis and tumor growth, little is known about their presence function during perioperative period. Here, we demonstrated that human MDSCs expressing CD11b + , CD33 HLA‐DR – significantly increased lung cancer patients after thoracotomy. isolated 24 hr surgery from were more efficient promoting growth than before surgical operation allograft model. In addition, produced high levels...