A5064251243- Cancer-related molecular mechanisms research
- Congenital heart defects research
- Lipoproteins and Cardiovascular Health
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Cardiomyopathy and Myosin Studies
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Cancer Immunotherapy and Biomarkers
- Oral and gingival health research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Head and Neck Cancer Studies
- CRISPR and Genetic Engineering
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2021-2022
Key Laboratory of Guangdong Province
2022
State Key Laboratory of Oncology in South China
2022
BGI Group (China)
2016-2021
China National GeneBank
2018
University of Chinese Academy of Sciences
2016
Northwestern University
2004-2005
Abstract Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes centenarians, whose genomes may harbor genetic variants health and longevity. Here we report a association study (GWAS) Han Chinese size 2.7 times the largest previously published GWAS on centenarians. We 11 independent replicated in Southern-Northern regions China, including novel (rs2069837- IL6 ; rs2440012- ANKRD20A9P ) significance rest...
The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset CX3CR1+ macrophages mainly located intima roots and ascending aortas Fbn1C1041G/+ mice, further validated MFS patients. Specific elimination cells by diphtheria toxin Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice efficiently ameliorated...
Focal iron overload is frequently observed in patients with rheumatoid arthritis (RA), yet its functional significance remains elusive. Herein, we report that deposition lesion aggravates by inducing macrophage ferroptosis. We show excessive synovial fluid positively correlates RA disease severity as does lipid hyperoxidation of focal monocyte/macrophages. Further study reveals high susceptibility to induced ferroptosis the anti-inflammatory macrophages M2, while pro-inflammatory M1 are less...
Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to risk rupture without effective treatments. The current understanding pathogenesis TAA still limited, especially for sporadic TAAs known genetic mutation. Sirtuin 6 (SIRT6) expression was significantly decreased in tunica media human tissues. Genetic knockout Sirt6 mouse smooth muscle cells accelerated formation rupture,...
Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for mortality patients with SLE-related AP in cohort South China. Methods . Inpatient medical records were retrospectively reviewed. Results 27 out 4053 SLE diagnosed as AP, an overall prevalence 0.67%, annual incidence 0.56‰ 37.04%. presented higher SLEDAI score (<mml:math...
Cardiac differentiation from human pluripotent stem cells provides a unique opportunity to study heart development in vitro and offers potential cell source for cardiac regeneration. Compared the large body of studies investigating maturation cardiomyocyte subtype-specific induction, molecular events underlying lineage commitment at early stage remain poorly characterized.In order uncover key regulators controlling state during differentiation, we performed single-cell RNA-Seq sequencing...
Aberrant number and/or dysfunction of CD4+Foxp3+ Regulatory T cells (Tregs) are associated with the pathogenesis rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural Tregs (nTregs) prefer to accumulate in inflamed joints and transdifferentiate TH17 under stimulation synovial fibroblasts (SFs). In this study, we made a head-to-head comparison both Treg subsets induced (iTregs), but not nTregs, retained Foxp3 expression regulatory function on effector...
Fibroblast-like synoviocytes (FLSs) play a critical role in promoting synovial aggression and joint destruction rheumatoid arthritis (RA). Cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) signaling plays an important controlling series cellular biological processes. However, it is still unclear whether cGAS/STING regulates aggression.Cell migration invasion were detected using Transwell chamber. Gene expression was measured quantitative reverse transcription-polymerase...
The beneficial effects of statins are usually assumed to stem from their ability reduce cholesterol biosynthesis. However, because potent inhibitors the mevalonate, which governs diverse cell signaling pathways, inhibition 3-hydroxy-3-methylglutaryl-coenzyme-A reductase may also result in pleiotropic effects. present study describes a novel effect on vascular endothelial growth factor (VEGF)-induced glomerular (GEnC) hyperpermeability. Using live imaging with green fluorescent protein-tagged...
Abstract The B cells inhabited in mucosa play a vital role mediating homeostasis with autoantigens and external Ags. Tumor-infiltrating lymphocytes are potential prognostic markers therapeutic agents for cancer. However, the spatial heterogeneity of cell repertoire intestinal tumor-infiltrating colorectal cancer (CRC) remain poorly understood. In this study, we developed an unbiased method to amplify IgH repertoire, as well bioinformatic pipeline process these high-throughput sequencing...
Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed explore the survival benefit LT directed at NPC.A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall (OS) rate analyzed using Kaplan-Meier method compared by log-rank test. Multivariate performed Cox hazard model. Subgroup analyses evaluating effect were for prespecified covariates....
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors exert modulatory effects on a number of cell signaling cascades by preventing the synthesis various isoprenoids derived from mevalonate pathway. In present study, we describe novel pleiotropic effect HMG-CoA inhibitors, also commonly known as statins, vascular endothelial growth factor (VEGF)-induced type IV collagen accumulation. VEGF is an angiogenic polypeptide that to play central role in permeability and...
ABSTRACT. Recent experimental observations have suggested that statins may exert modulatory effects on a number of pathobiological processes beyond their cholesterol-lowering properties. Some the pleiotropic seem to be mediated by ability block synthesis isoprenoid intermediates, which serve as important lipid attachments required for proper function and activation small GTP-binding proteins. The current study explored simvastatin (SMV) angiotensin II (Ang II)-induced Rac1-mediated,...
HBV integration and function has gradually been expanding. However, the exact mode of remains unclear. In our research, high-throughput long-read sequencing was combined with bioinformatics to study complete in hepatocellular carcinoma (HCC) cells. The results demonstrated that: 1) insertion sequences events accounted for 49.5% total sequences. 2) Short segments length 0-1 kbp 50% long (>3 kbp) 25% events. 3)There were different breakpoints formed within regions. 4) occurrence accompanied by...
Abstract Y-chromosomal microdeletion (YCM) serves as an important genetic factor in non-obstructive azoospermia (NOA). Multiplex polymerase chain reaction (PCR) is routinely used to detect YCMs by tracing sequence-tagged sites (STSs) the Y chromosome. Here we introduce a novel methodology which sequence 1,787 (post-filtering) STSs distributed across entire male-specific chromosome (MSY) parallel uncover known and YCMs. We validated this approach with 766 Chinese men NOA 683 ethnically...
Emerging evidence indicate that long noncoding RNAs (lncRNAs) may play an important role in the pathogenesis of systemic lupus erythematosus (SLE) however, contribution lncRNAs to SLE remains largely unclear. Our study aimed explore lncRNA expression profiles peripheral blood mononuclear cells (PBMCs) from patients.
Abstract A therapeutic strategy using mesenchymal stem cells (MSCs) has been accepted as a novel therapy for treating rheumatoid arthritis (RA). Human gingiva‐derived MSCs (GMSCs) are superior in regulating immune responses. Autologous the optimal candidate to avoid potential risks of allogenic MSCs. However, whether autologous GMSCs from RA patients remains unknown. In this study, we compared efficacy derived with (RA‐GMSCs) and that health donors (H‐GMSCs) vivo vitro. Then, utilized...
Dynamic establishment of histone modifications in early development coincides with programed cell fate restriction and loss totipotency beyond the blastocyst stage. Causal function histone-modifying enzymes this process remains to be defined. Here we show that inhibiting methyltransferase MLL1 reprograms naive embryonic stem cells (ESCs) expanded pluripotent (EPSCs), differentiation potential toward both extraembryonic lineages vitro vivo. inhibition or deletion upregulates gene signatures...
Background: Therapeutic strategy using mesenchymal stem cells (MSCs) has been accepted as a novel therapy for treating rheumatoid arthritis (RA). Human gingiva derived MSCs (GMSCs) are capable in modulating immune responses. To avoid the potential risks of allogenic MSC, autologous optimal candidate. However, whether GMSCs from RA patients (RA-GMSCs) therapeutic remains unknown. Herein, we investigated effect RA-GMSCs collagen induced (CIA) and humanized synovitis mice model.Methods: We...