A5101892434- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Chemokine receptors and signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lipid metabolism and disorders
- Tryptophan and brain disorders
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Tendon Structure and Treatment
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Drug-Induced Hepatotoxicity and Protection
- Foot and Ankle Surgery
- Immunotherapy and Immune Responses
Guangzhou Medical University
2008-2024
Guangzhou First People's Hospital
2008-2024
South China University of Technology
2019-2024
Objective T cells display significant phenotypical changes and play multiple roles in promoting the immune response SLE. The frequencies of cell subpopulations SLE are still not well understood. To better understanding phenotypic abnormalities will help us to clarify disease immunopathology find promising biomarkers for monitoring control. Methods Peripheral blood CD4 + CD8 their subsets were determined by flow cytometry. Forty-one active patients selected, including 28 new-onset 13...
Objective . There is evidence that interleukin-6 (IL-6) upregulation plays a critical role in immunopathology of systemic lupus erythematosus (SLE). MicroRNA- (miRNA-) 98 was predicted to bind with the 3<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:msup><mml:mrow/><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msup></mml:math>-untranslated region (3<mml:math id="M2"><mml:msup><mml:mrow/><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msup></mml:math>-UTR) IL-6 gene. We...
Human gamma-delta T cells (γδ-T cells) play crucial roles in both innate and adaptive immune responses. However, much less is known about the status of γδT systemic lupus erythematosus (SLE) patients. The objective this study was to explore potential relationships between frequency γδ-T-cell subpopulations disease activity, autoantibody titres renal involvement patients with SLE.
To explore the expression and significance of Th17 Treg cells in peripheral blood patients with systemic lupus erythematosus (SLE).Thirty active SLE (including 17 nephritis), 20 inactive healthy controls were enrolled. The expressions CD4+CD25+Foxp3+Treg mononuclear (PBMC) evaluated by flow cytometry. correlations between cells, disease activity (SLEDAI), as well ratios (Th17/Treg) analyzed respectively.The PBMC was higher than that [(1.39 ± 0.60)% vs (0.80 0.33)%, P < 0.01] while decreased...
Emerging evidence indicate that long noncoding RNAs (lncRNAs) may play an important role in the pathogenesis of systemic lupus erythematosus (SLE) however, contribution lncRNAs to SLE remains largely unclear. Our study aimed explore lncRNA expression profiles peripheral blood mononuclear cells (PBMCs) from patients.
To analyze peripheral blood interleukin 6 (IL-6) methylation status and its clinical significance in patients with systemic lupus erythematosus (SLE).Blood samples from 41 adult SLE, 20 healthy controls were collected. The of IL-6 was determined by specific polymerase chain reaction (MSP). expression detected real-time PCR. Correlations between features or laboratory findings SLE investigated.The could reflect the level mononucleated cells (PBMCs) SLE. Significantly positive correlation...
Abstract This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury. Sprague-Dawley rats were intraperitoneally administered with TAA, then injected intraperitoneally, and/or orally provided XSLJZD. TAA resulted in liver injury increases index levels serum aspartate aminotransferase (AST) alanine aminotransferase. Reversine alleviated AST level improved TAA-induced pathological...
Objective To investigate the changes and clinical significance of equilibrium peripheral blood helper T cell 17 (Th17)-regulatory (Treg) in patients with systemic lupus erythematosus (SLE).Methods Forty active SLE,40 clinically stable SLE patienls 20 healthy volunteers were enrolled this study.Changes Th17/Treg ratio its correlation disease activity determined following detection Th17 cells Treg by flow cytometry.Real-time fluorescent quantitative PCR was employed to examine expression...
Objective To investigate the risk factors of disease progression and adverse pregnancy outcome in patients with systemic lupus erythematosus (SLE) during pregnancy. Methods Clinical data 118 pregnant women SLE admitted from June 2004 to October 2015 were retrospectively analyzed. The divided into selective group (group A, n=72 cases) non-selective B, n=46) according activity SLE. outcomes compared between two groups. Results The various system damages occurred including...
Abstract Background: Whether the bone graft is needed in treating displaced intra-articular calcaneal fractures (DIACFs) still controversial. Therefore, our study, we will explore results of 2 approaches for DIACFs surgical treatment. Methods: The present report follows Consolidated Standards Reporting Trials (CONSORT) guidelines. All patients be assigned randomly into different groups through tossing coins. Three experienced surgeons are to each group implement surgeries utilizing any...
Objective To investigate the expression of interleukin- 35+ regulatory B cells (IL-35+ Bregs) in peripheral blood patients with systemic lupus erythematosus (SLE) , and its role pathogenesis SLE. Methods Fifty SLE treated our Department Rheumatology Immunology between January 2015 2016 were included this study. According to disease activity index (SLEDAI) assigned active group (n=30) stable (n=20). A contemporary cohort 20 healthy volunteers was recurited as normal control group....
Objective To investigate the expression and significance of B lymphocyte stimulator (Blys) its receptor BAFF (BAFF-R) in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE). Methods The Blys BAFF-R was measured by flow cytometry 90 pa-tients SLE,which compared that 45 healthy controls. relationships between Blys, other laboratory parameters as well disease activity were analyzed. Results PBMCs SLE significantly elevated to controls (P <0.001), so...