A5073863775- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Insect Resistance and Genetics
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Redox biology and oxidative stress
- Silk-based biomaterials and applications
- Genomics, phytochemicals, and oxidative stress
- Thyroid Cancer Diagnosis and Treatment
- Renal and related cancers
- Invertebrate Immune Response Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Pregnancy-related medical research
- Musculoskeletal pain and rehabilitation
- Neuroscience of respiration and sleep
- Silkworms and Sericulture Research
- Spinal Fractures and Fixation Techniques
- Plant and Fungal Interactions Research
- Phytochemicals and Antioxidant Activities
University of South China
2019-2023
Weatherford College
2023
First Affiliated Hospital of Wannan Medical College
2020
South China Normal University
2014-2020
Beike Biotechnology (China)
2019
Second Military Medical University
2014
Changhai Hospital
2014
Recently, a large number of long non-coding RNAs (lncRNAs) have been reported in mammalian genomes and are evolutionarily conserved presumably function many biological events, especially the pathogenesis diverse human cancers. A lncRNA, named HOST2 (human ovarian cancer-specific transcript 2), was once to specifically be expressed at high level cancer. However, how acts regulate gene functions carcinogenesis has remained enigmatic. Here we report, for first time, that promotes tumor cell...
Wing discs of B. mori are transformed to pupal wings during the larva-to-pupa metamorphosis with dramatic morphological and structural changes. To understand these changes at a transcriptional level, RNA-seq wing from 6-day-old fifth instar larvae (L5D6), prepupae (PP) pupae (P0) was performed. In total, 12,254 transcripts were obtained disc, out which 5,287 identified be differentially expressed L5D6 PP P0. The results comprehensive analysis data showed that larvae-to-pupae metamorphosis,...
Abstract Background Thyroid dysfunction is a common thyroid disorder in our life and its symptoms are non‐specific, therefore the diagnosis of important for patients. Albumin (ALB) can carry hormones to their sites action as way achieve rapid delivery tissues. The purpose this study was investigate relationship between serum ALB levels total triiodothyronine (TT3) adults. Methods Data from 2007–2012 National Health Nutrition Examination Survey (NHANES) were used examine association TT3 using...
The importance of circular RNAs (circRNAs) as regulators muscle development and muscle-associated disorders is becoming increasingly apparent. To explore potential differentiation, we determined the expression profiles circRNAs skeletal C2C12 myoblasts myotubes using microarray analysis. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses were performed to circRNA functions. We also established competing endogenous RNA (ceRNA) networks bioinformatics methods predicted coding...
Study Design. In vitro studies of the role 17β-estradiol (E2) and its possible targets in intervertebral disc degeneration (IDD). Objective. To define regulatory E2 IDD potential mechanisms. Summary Background Data. has intricate etiology that is influenced by multiple risk factors. However, underlying molecular mechanisms occurrence progression are not well elucidated. The degradation extracellular matrix (ECM) been extensively observed IDD. was found to inhibit ECM human nuleus pulposus...
CX3C chemokine ligand 1 (CX3CL1) belongs to the family and is involved in various disease processes. However, its role intervertebral disc degeneration (IDD) remains be elucidated. In present study, western blotting, reverse transcription-quantitative PCR ELISA assays were used assess target gene expression. addition, immunofluorescence TUNEL staining macrophage infiltration, monocyte migration apoptosis. The study aimed reveal if how CX3CL1 regulates IDD progression by exploring effect on...
This study aimed to investigate the SALL4 expression in lung cancer, determine if regulates biological functions of cancer cells at cellular level, and clarify possible mechanisms involved.Immunohistochemistry was used detect messenger RNA (mRNA) 62 cases tissue microarray. The correlation with clinical pathological parameters overall life cycle patients impact disease-free analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) western blotting were cell lines nude mouse models....
Abstract Background Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) most serious agricultural pests in Asia countries. An interesting unique phenomenon for gonad development testicular fusion. Two separated testes fused into a single during larva-to-pupa metamorphosis, which believed to contribute sperm production prevalence field. To study molecular mechanism fusion, RNA sequencing (RNA-seq) experiments from 4-day-old sixth instar...
Aim: We aimed to explore potential regulators of coding and noncoding RNAs (ncRNAs) in Co(II) ion-induced myo cytotoxicity. Materials & methods: confirmed the toxic effects on mouse skeletal C2C12 myotubes by CoCl2, performed expression profiles circular (circRNAs), long (lncRNAs) mRNAs using microarray analysis. constructed co-expression, competing endogenous RNA cis/trans regulation networks for ncRNAs, filtered 71 candidate circRNAs with potential. Results: identify 605 differentially...
Flavonoids have been shown to be beneficial in a variety of inflammatory and metabolic diseases because their anti-inflammatory antioxidant properties. However, previous epidemiological studies only demonstrated negative correlation between flavonoid intake on markers, the optimal dietary flavonoids subclasses terms efficacy remains undetermined. This study was based 3 cycles (2007-2010, 2017-2018) National Health Nutrition Examination Survey corresponding expanded database. Weighted...
Sulfiredoxin‑1 (SRX1) is a conserved endogenous antioxidative protein, which involved in the response to cellular damage caused by oxidative stress. Oxidative stress and inflammation are primary pathological changes spinal cord injuries (SCI). The aim of present study was explore roles SRX1 SCI. Using reverse transcription‑quantitative PCR western blotting, discovered that expression levels were downregulated tissues SCI model rats. Massive irregular cavities decreased Nissl bodies observed...
Objective. The study aimed to investigate the effect of anterior cervical surgery in treatment spinal cord injury without radiographic abnormalities (SCIWORAs) and analyze related factors affecting prognosis patients. Methods. A total 86 patients with SCIWORA who were admitted our hospital from June 2018 March 2021 selected as research subjects. According different methods by patients, they divided into control group (n = 38) observation 48). was treated conservative therapy, laminectomy...
Abstract Background: Whether the bone graft is needed in treating displaced intra-articular calcaneal fractures (DIACFs) still controversial. Therefore, our study, we will explore results of 2 approaches for DIACFs surgical treatment. Methods: The present report follows Consolidated Standards Reporting Trials (CONSORT) guidelines. All patients be assigned randomly into different groups through tossing coins. Three experienced surgeons are to each group implement surgeries utilizing any...
Abstract Background Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) most serious agricultural pests in Asia countries. An interesting unique phenomenon for gonad development testicular fusion. Two separated testes fused into a single during larva-to-pupa metamorphosis, which believed to contribute sperm production prevalence field. To study molecular mechanism fusion, RNA sequencing (RNA-seq) experiments from 4-day-old sixth instar...
Abstract Background Lepidoptera is one group of the largest plant-feeding insects and Spodoptera litura (Lepidoptera: Noctuidae) most serious agricultural pests in Asia countries. An interesting unique phenomenon for gonad development testicular fusion. Two separated testes fused into a single during larva-to-pupa metamorphosis, which believed to contribute sperm production prevalence field. To study molecular mechanism fusion, RNA sequencing (RNA-seq) experiments from 4-day-old sixth instar...