A5050720539- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Advanced Biosensing Techniques and Applications
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Biosensors and Analytical Detection
- Paraquat toxicity studies and treatments
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Gout, Hyperuricemia, Uric Acid
- Photosynthetic Processes and Mechanisms
- Parathyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- Lipid metabolism and disorders
- Chronic Lymphocytic Leukemia Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Growth Hormone and Insulin-like Growth Factors
- MRI in cancer diagnosis
- Chemokine receptors and signaling
- Liver Disease Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Algal biology and biofuel production
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
University of Houston
2016-2025
Guangxi University of Chinese Medicine
2025
Fujian University of Traditional Chinese Medicine
2025
Center for Clinical Studies
2024
North Carolina State University
2023
State Key Laboratory of Food Science and Technology
2021
Jiangnan University
2021
Hualien Tzu Chi Medical Center
2019
The University of Texas Southwestern Medical Center
2007-2017
Shanghai Tenth People's Hospital
2012-2016
Fungal keratitis, a severe ocular disease, is one of the leading causes morbidity and blindness, yet it often neglected, especially in developing countries. Therapeutic efficacy traditional treatment such as eye drops very limited due to poor bioavailability, whereas intraocular injection might cause serious side effects. Herein, we designed fabricated hybrid hydrogel-based contact lens which comprises quaternized chitosan (HTCC), silver nanoparticles, graphene oxide (GO) with combination...
Nephrophilic autoantibodies dominate the seroprofile in lupus, but their fine specificities remain ill defined. We constructed a multiplexed proteome microarray bearing about 30 antigens known to be expressed glomerular milieu and used it study serum lupus. Compared with normal serum, from B6.Sle1.lpr lupus mice (C57BL/6 homozygous for NZM2410/NZW allele of Sle1 as well FAS defect) exhibited high levels IgG IgM antiglomerular anti-double-stranded DNA/chromatin Abs variable alpha-actinin,...
The metabolic disturbances that underlie systemic lupus erythematosus are currently unknown. A metabolomic study was executed, comparing the sera of 20 SLE patients against healthy controls, using LC/MS and GC/MS platforms. Validation key differences performed an independent cohort 38 orthogonal assays. showed evidence profoundly dampened glycolysis, Krebs cycle, fatty acid β oxidation amino metabolism, alluding to reduced energy biogenesis from all sources. Whereas long-chain acids,...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that characterized by defective immune tolerance combined with cell hyperactivity resulting in the production of pathogenic autoantibodies. Previous gene expression studies employing whole blood or peripheral mononuclear cells (PBMC) have demonstrated majority patients active increased type I interferon (IFN) inducible transcripts known as IFN signature. The goal current study was to assess profiles isolated leukocyte subsets...
Abstract In an effort to identify potential biomarkers in lupus nephritis, urine from mice with spontaneous nephritis was screened for the presence of VCAM-1, P-selectin, TNFR-1, and CXCL16, four molecules that had previously been shown be elevated experimental immune particularly at peak disease. Interestingly, all were ∼2- 4-fold several strains including MRL/lpr, NZM2410, B6.Sle1.lpr strains, correlating well proteinuria. CXCL16 enriched compared serum active disease, expressed within...
Abstract Introduction Although renal pathology is highly predictive of the disease course in lupus nephritis, it cannot be performed serially because its invasive nature and associated morbidity. The goal this study to investigate whether urinary levels CXC ligand 16 (CXCL16), monocyte chemotactic protein-1 (MCP-1) or vascular cell adhesion molecule-1 (VCAM-1) patients with nephritis are particular features biopsies obtained on day urine procurement. Methods CXCL16, MCP-1, VCAM-1 were...
There is a critical need to identify biomarkers for Systemic Lupus Erythematosus (SLE) which has high prevalence of renal failure. When urine from patients with lupus nephritis was recently screened the levels ∼280 molecules using an exploratory array-based proteomic platform, elevated angiostatin were noted. Angiostatin bioactive fragment plasminogen, and been known have modulatory function in angiogenesis inflammation. The significant elevation urinary next validated independent cohort SLE...
Abstract Introduction In a recent screening to detect biomarkers in systemic lupus erythematosus (SLE), expression of the iron storage protein, ferritin, was increased. Given that proteins regulate storage, transfer and release play an important role inflammation, this study aims determine serum urine levels ferritin transferrin, patients correlate these with disease activity, inflammatory cytokine markers anemia. Methods A protein array utilized measure SLE healthy controls. To confirm...
Various flexible SERS sensors have attracted widespread concern in performing the direct identification of analytes adsorbed on arbitrary surfaces. Here, a sample method was proposed to integrate plasmonic nanoparticles into polydimethylsiloxane (PDMS) fabricate substrate for decoration silver (AgNPs). The sensor based AgNPs/AgNPs-PDMS offers highly sensitive Raman detection with enhancement factor up 8.3 × 109, which can be attributed integrative effects from both increase light absorption...
Abstract Substrate design has attracted much interest in development of an effective surface enhanced Raman scattering (SERS) sensor. A flexible SERS substrate with excellent performance needs to be sensitive details the preparation process; this sensitivity represents a significant challenge for practical applications as opposed laboratory research applications. Here, 3D plasmonic structure, AgNPs@MoS 2 /pyramidal polymer (polymethyl methacrylate), is fabricated using simple and low‐cost...
Objective The autoimmune etiology in psoriasis remains to be clarified. We therefore undertook this study identify novel pathogenic autoantigens and autoantibodies patients with psoriasis, the aim of shedding light on molecular cellular basis pathogenesis psoriatic arthritis (PsA). Methods In study, we developed an autoantigen array system that harbors a variety antigens, including typical rheumatic diseases as well skin inflammatory mediators, putative psoriasis. Serum samples from (n = 73)...
Though B cells play key roles in lupus pathogenesis, the molecular circuitry and its dysregulation these as disease evolves remain poorly understood. To address this, a comprehensive scan of multiple signaling axes using multiplexed Western blotting was undertaken several different murine strains. PI3K/AKT/mTOR (mTOR, mammalian target rapamycin), MEK1/Erk1/2, p38, NF-κB, Bcl-2 family members, cell-cycle molecules were observed to be hyperexpressed an age-dependent susceptibility...
To characterize the antimicrobial and adhesion ability of candidate probiotic Clostridium butyricum CB2 for farmed fish in vitro.The potential Cl. had been evaluated its capacity antagonistic effect against two pathogens Aeromonas hydrophila Vibrio anguillarum by intestinal cell model. In addition, aggregation property on agar plate were assayed. The results indicated that have strong a higher activity to Aer. V. both showed which might be reasons bacteria activity.The strain could used as...
Abstract Clostridium butyrium CB2 isolated from chickens was tested as a potential fish probiotic in the Chinese drum, Miichthys miiuy . Fish were fed live (CB), dead (D‐CB) cells (10 8 g −1 ) or spent culture supernatant (SCS), for 30 days and challenged with Vibrio anguillarum Aeromonas hydrophila Survival higher both CB CB‐D groups, but SCS group not significantly different control. After feeding cells, there increase phagocytic activity of head kidney macrophages, lysozyme serum gut...
The aim of this study was to investigate the clinical significance real-time gray-scale contrast-enhanced ultrasound (CEUS) through evaluating renal microvascular perfusion in diabetic kidney damage.Diabetic patients (aged: 62.5±7.2, n=33) were divided into Group A with chronic disease (CKD) Stages I and II (n=19) B (n=14) CKD IV V. Twenty-one healthy adults selected as control group. dynamic imaging from cortex performed using SonoVue. outage time-intensity curves (TICs) >85%...
Background Dysregulaiton of phosphate homeostasis as occurs in chronic kidney disease is associated with cardiovascular complications. It has been suggested that both hyperphosphatemia and hypophosphatemia can cause disease. The molecular mechanisms by which high or low serum levels adversely affect function are poorly understood. purpose this study was to explore the endothelial dysfunction presence non-physiologic levels. Methodology/Principal Findings We studied effects simulated hyper-...
A discovery study was carried out where serum samples from 22 systemic lupus erythematosus (SLE) patients and matched healthy controls were hybridized to antibody-coated glass slide arrays that interrogated the level of 274 human proteins. On basis these screens, 48 proteins selected for ELISA-based validation in an independent cohort 28 SLE patients. Whereas AXL, ferritin, sTNFRII significantly elevated with active nephritis (LN) relative who quiescent, other molecules such as OPN, sTNFRI,...