A5100462711- RNA modifications and cancer
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Human Pose and Action Recognition
- Microbial Community Ecology and Physiology
- Advanced Proteomics Techniques and Applications
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Ruminant Nutrition and Digestive Physiology
- Privacy-Preserving Technologies in Data
- RNA and protein synthesis mechanisms
- Tryptophan and brain disorders
- Bone health and treatments
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- Video Surveillance and Tracking Methods
- Cancer-related gene regulation
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Educational Technology and Pedagogy
- 3D Shape Modeling and Analysis
- Antibiotic Resistance in Bacteria
- Pancreatitis Pathology and Treatment
Shandong University
2021-2025
Zhejiang University
2025
Fudan University
2012-2025
Guangxi University
2025
Xuzhou Medical College
2024
Ocean University of China
2022-2024
First Affiliated Hospital of Zhengzhou University
2024
Zigong First People's Hospital
2024
Affiliated Hospital of Southwest Medical University
2024
Hebei University of Science and Technology
2024
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated medicated patients SCZ had decreased α-diversity index marked disturbances of microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae Lachnospiraceae) were associated severity. A specific panel...
Abstract Purpose To understand which environmental factors influence the distribution and ecological functions of bacteria in agricultural soil. Method A broad range farmland soils was sampled from 206 locations Jilin province, China. We used 16S rRNA gene-based Illumina HiSeq sequencing to estimated soil bacterial community structure functions. Result The dominant taxa terms abundance were found be, Actinobacteria, Acidobacteria, Gemmatimonadetes, Chloroflexi, Proteobacteria. Bacterial...
Significance Rare recessive monogenic diseases are often found in isolated populations. In one such population, we identified a child carrying homozygous nonsense mutation an understudied smooth muscle-restricted gene called Leiomodin1 ( LMOD1 ). Heterozygous parents showed no disease; however, the died shortly after birth from rare condition known as megacystis microcolon intestinal hypoperistalsis syndrome. A mouse model with similar Lmod1 mutation, engineered CRISPR-Cas9 genome editing,...
To ascertain the importance of a single regulatory element in control Cnn1 expression using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) genome editing.The system was used to produce 3 18 founder mice carrying point mutations an intronic CArG box smooth muscle cell-restricted gene. Each bred for germline transmission mutant and littermate interbreeding generate homozygous (Cnn1(ΔCArG/ΔCArG)) mice. Quantitative reverse transcription...
Salinity is an important environmental factor that directly affects the survival of aquatic organisms, including fish. However, underlying molecular mechanism salinity adaptation at post-transcriptional regulation levels still poorly understood in In present study, 18 RNA-Seq datasets were utilized to investigate potential roles alternative splicing (AS) response different environments livers three euryhaline teleosts, turbot (Scophthalmus maximus), tongue sole (Cynoglossus semilaevis) and...
Breast cancer is a major cause of death in women, and various drug therapies are used for its treatment. However, current have many side effects limitations. Propolis, resinous product bee hives, possesses variety biological activities, including anticancer chemo-protective properties. The present study aimed to investigate the potential suitability propolis-derived compounds inhibit matriptase (MT-SP1), protein target breast treatment, through comprehensive computational analysis. MT-SP1...
Abstract Objectives Secondary bacterial pneumonia is common following influenza infection. However, it remains unclear about the underlying molecular mechanisms. Materials and methods We established a mouse model of post‐influenza S aureus using conditional Shp2 knockout mice ( LysM Cre/+ :Shp2 flox/flox ). The survival, clearance, pulmonary histology, phenotype macrophages, expression type I interferons chemokines were assessed between SHP2 deletion control infused additional KC MIP‐2 to...
Background: Inflammatory disorder and acinar cell death contribute to the initiation progression of severe acute pancreatitis (SAP). Adenosine kinase (ADK) has potential effects on both inflammation death. However, role ADK in SAP remains be explored. Methods: To establish an experimental model, male C57BL/6 mice were intraperitoneally injected with cerulein (50 μg/kg, seven doses at hourly intervals) LPS (10 mg/kg, last injection). For inhibition, ABT702 (1.5 mg/kg) was 1 h before...
Ulcerative colitis is a chronic and relapsing inflammatory bowel disease without satisfactory therapy available recently. Renshen Baidu powder (RSBDP) classic Chinese medicinal formula used since Song dynasty has been proven as an effective treatment of ulcerative in clinics. However, the active ingredients molecular mechanism have not fully disclosed. It imperative to explore RSBDP. In this study, potential components for RSBDP were determined predicted silicon, its mechanisms also...
Eutrophication-induced water deoxygenation occurs continually in coastal oceans, and alters community structure, metabolic processes, the energy shunt, resulting a major threat to ecological environment. Seasonal events have occurred Bohai Sea (China), however, how these affect functional activity of microorganisms remains unclear. Here, through use absolute quantification 16S rRNA genes amplicon sequencing metatranscriptomics approaches, we investigated structure microbial patterns...
Background: Necroptosis is a vital regulator of myocardial ischemia/reperfusion (MI/R) injury. Meanwhile, 4-hydroxy-2-nonenal (4-HNE) abundantly increased during MI/R However, whether 4-HNE induces cardiomyocyte necroptosis remains unknown. Methods: To observe the relationship between and MI/R, C57BL/6 mice aldehyde dehydrogenase 2-transgenic (ALDH2-Tg) were both exposed to left anterior descending artery ligation surgery establish injury models. For further study, isolated mouse hearts H9c2...
Abstract Background The gastrointestinal tract (GIT) microbiome of ruminants and its metabolic repercussions vastly influence host metabolism growth. However, a complete understanding the bidirectional interactions that occur across host-microbiome axis remains elusive, particularly during critical development stages at early life. Here, we present an integrative multi-omics approach simultaneously resolved taxonomic functional attributes microbiota from five GIT regions as well features...
We performed a multi-omics analysis to examine the molecular mechanisms of aging in mouse skeletal and cardiac muscles. A computational workflow is developed filter transcriptomics data based on how well might predict protein level changes.
Abstract Background Long noncoding RNAs (lncRNAs) play vital regulatory functions in non-small cell lung cancer (NSCLC). Cisplatin (DDP) resistance has significantly decreased the effectiveness of DDP-based chemotherapy NSCLC patients. This study aimed to investigate effects SH3PXD2A antisense RNA 1 (SH3PXD2A-AS1) on DDP NSCLC. Methods Proliferation and apoptosis DDP-resistant cells were detected using counting kit-8 flow cytometry assays. The interaction between SH3PXD2A-AS1 sirtuin 7...