A5100420275- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- IgG4-Related and Inflammatory Diseases
- Bladder and Urothelial Cancer Treatments
- Phytochemistry and biological activity of medicinal plants
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Liver Diseases and Immunity
- Neuroendocrine Tumor Research Advances
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Renal cell carcinoma treatment
- Microbial Natural Products and Biosynthesis
- Pancreatic and Hepatic Oncology Research
- Fungal Biology and Applications
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Gallbladder and Bile Duct Disorders
- Dialysis and Renal Disease Management
- Lung Cancer Treatments and Mutations
- Autoimmune Bullous Skin Diseases
- Phytochemistry and Biological Activities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Disorders and Functions
- Toxin Mechanisms and Immunotoxins
Southwest Hospital
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Army Medical University
2009-2025
Peking Union Medical College Hospital
2016-2025
Shenzhen Maternity and Child Healthcare Hospital
2024-2025
Southern Medical University
2025
West China Second University Hospital of Sichuan University
2024
Fujian Medical University
2024
Xizang Minzu University
2024
Yibin Vocational and Technical College
2024
CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment advanced/metastatic non-small-cell lung cancer (NSCLC). We assessed association with programmed death ligand 1 (PD-L1) expression tumor mutational burden (TMB).Two hundred eighty-eight patients previously untreated, recurrent stage IIIB/IV NSCLC received 3 mg/kg every 2 weeks 6 weeks. The primary end point was objective response rate (ORR) in 1%...
Abstract Objectives To study the impact of sex on clinical presentation IgG4-related disease (IgG4-RD). Methods We prospectively enrolled 403 newly diagnosed IgG4-RD patients. compared demographic features, manifestations, organ involvement, laboratory tests and treatment outcomes between female male The organs involved were divided into superficial (salivary glands, lacrimal orbit, sinus skin) internal (all other organs). patients treated with glucocorticoids or without additional...
Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported to inhibit viral replication through multiple modes. Previous work showed that human MARCH8 blocked Ebola virus (EBOV) glycoprotein (GP) maturation. Our study here demonstrates MARCH1 and MARCH2 share a similar pattern in restricting EBOV GP‐pseudotyped infection. Human retain GP at the trans ‐Golgi network, reduce its cell surface display, impair virions infectivity. Furthermore, we uncover host proprotein...
Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two genogroups (GI and GII) approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recently crystal structures HBGA-binding interfaces GI Norwalk virus GII VA387 have been determined, which allows us to examine genetic structural relationships with variable patterns. Our hypothesis is that, if...
Abstract Background: Several studies have demonstrated the potential clinical utility of TMB as a biomarker immune checkpoint blockade in multiple tumor types, including lung cancer. Prior analyses been retrospective and exploratory, with varying cutoffs methodologies used to assess TMB. The establishment clinically validated cutoff for nivo + ipi is required confirm predictive future studies. CheckMate 568 (NCT02659059) large, single-arm, phase 2 study 1L NSCLC. was assessed using...
3001 Background: Nivo + ipi is approved in adv melanoma and has demonstrated clinical activity manageable safety various solid tumors. CheckMate 012 a phase I study of nivo monotherapy or combined with other therapies 1L NSCLC; we report updated results, including tumor growth dynamic (TGD) modeling, from N+I dosing schedules explored to optimize permit synergistic activity. Methods: Patients ([pts] N=148, any NSCLC histology) received (mg/kg) across 4 dose cohorts (Table). Primary objective...
Oryzaeins A–D (<b>1</b>-<b>4</b>), four new isocoumarin derivatives, along with five known ones (<b>5</b>-<b>9</b>) were isolated from solid cultures of an endophytic fungus <i>Aspergillus oryzae</i>. Their structures elucidated by detailed spectroscopic analysis and comparison reported data related derivatives. Among them, compounds <b>1</b> <b>2</b> represent the first examples isocoumarins possessing unusual 2-oxopropyl group a rare 3-hydroxypropyl group. Compounds displayed moderate...
Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic that can involve multiple organs and various clinical phenotypes. The purpose of this study was to analyze different types organ involvement in IgG4-RD patients China.We conducted prospective cohort on the manifestations rare features IgG4-RD. Patients were grouped into according regarding number site. constituent ratio also analyzed.A total 200 patients, with male:female 2.08:1, types. Cases having two or three most...
Abstract Background Large vessels could be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to clarify the clinical features and evaluate treatment efficacy for IgG4-RD with aortitis/periaortitis periarteritis (PAO/PA). Methods prospectively enrolled 587 patients a follow-up time of more than 6 months. The distribution IgG4-related PAO/PA was classified into four types: type 1, thoracic aorta; 2a, abdominal 2b, aorta iliac artery; 2c, 3, 4, other arteries....
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that represents prodigious challenge of diagnosis and treatment. In 2019, under the leadership Chinese Rheumatology Association, multidisciplinary guideline development group was established to develop an evidence-based treatment for patients with SLE in PR China. The Grading Recommendations Assessment, Development Evaluation (GRADE) approach used evaluate quality evidence strength recommendations. reported...
Cordyceps sinensis has been used to treat liver disease in traditional Chinese medicine for thousands of years. Polysaccharide extracted from cultured mycelia (CS-PS) is the major active components cordyceps with anti-liver injury effects. In present study, effects CS-PS on hepatic stellate cell (HSC) activation, transforming growth factor-β1 (TGF-β1)/Smad pathway, as well matrix metalloproteinase (MMP) 2, MMP9 and tissue inhibitor (TIMP) 1, TIMP2, were investigated fibrosis rats induced by...
Abstract Background Pathway studies highlight the help-seeking behaviors of patients with physical and mental illnesses. A number in this field have been completed various parts world. The purpose study is to explore characteristics pathways illness from urban north China at Mental Health Professional (MHP). Methods pathway diagrams, which accounted for more than five percent patients, were documented 441 subjects using translated version World Organization (WHO) encounter form. patterns...
Transforming growth factor-β1 (TGF-β1)‑induced epithelial‑mesenchymal transition (EMT) is one of the important cellular and molecular mechanisms involved in renal fibrosis. Smad3 miR-192 (a Smad3-dependent microRNA) are TGF-β1-mediated EMT. Vascular endothelial factor (VEGF) a tubular epithelial survival factor. Therefore, present study, we investigated role miR‑192 effects VEGF on TGF‑β1‑mediated A human kidney cortex (HKC) cell line stably overexpressing (HKC-SOEV) was established. The...
Abstract The B cells inhabited in mucosa play a vital role mediating homeostasis with autoantigens and external Ags. Tumor-infiltrating lymphocytes are potential prognostic markers therapeutic agents for cancer. However, the spatial heterogeneity of cell repertoire intestinal tumor-infiltrating colorectal cancer (CRC) remain poorly understood. In this study, we developed an unbiased method to amplify IgH repertoire, as well bioinformatic pipeline process these high-throughput sequencing...
Objective To investigate the value of repeat renal biopsy in treatment and prognosis nephrotic syndrome(NS)and acute kidney injury(AKI)following immunosuppressive therapy patients with lupus nephritis(LN).Methods A retrospective analysis was conducted for clinicopathological data follow-up records LN undergoing at Peking Union Medical College Hospital from January 1,2009 to December 31,2021.Results total 76 patients(55 females,72.4%)were included this study,with mean age first...
Abstract Backgrounds Although kidney impairments have been reported following immune checkpoint inhibitors (ICIs) in clinical studies, there are few pharmacoepidemiology studies to compare the occurrences, features, and prognosis of renal adverse effects. Methods Disproportionality Bayesian analysis were used data mining screen suspected effects after administration different ICIs, based on FDA's Adverse Event Reporting System (FAERS) from January 2004 September 2019. The time onset,...
Achieving methane-to-methanol is challenging under mild conditions. In this study, methanol synthesized by one-step direction conversion of CH4 with H2O at room temperature atmospheric pressure in non-thermal plasma (NTP). This route characterized the use methane and liquid water as reactants, which enables transfer product to phase time inhibit its further decomposition conversion. Therefore, obtained free carbon dioxide. The reaction products include gas liquid-phase hydrocarbons, CO,...
Our understanding of the molecular bases behind interplays between human noroviruses and their host glycan ligands, as well evolutionary changes over time with alterations in ligand binding capability susceptibility, remains limited. By solving crystal structures protruding (P) domains or without ligands three representative GII.17/13/21 genetic lineage, we elucidated norovirus-glycan interactions this special lineage. We present solid evidence on how lineage evolved via different paths to...