A5100712971- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Hippo pathway signaling and YAP/TAZ
- Data Visualization and Analytics
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- TGF-β signaling in diseases
- Cell death mechanisms and regulation
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
Ningbo University
2025
University of Utah
2024
Beijing University of Chemical Technology
2024
Bristol-Myers Squibb (United States)
2017-2024
City University of Hong Kong
2024
Tulane University
2014-2023
University of Chicago
2023
Sichuan University
2022
Shandong University
2022
Washington University in St. Louis
2020
Nivolumab plus ipilimumab showed promising efficacy for the treatment of non–small-cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as potential biomarker benefit. In this part an open-label, multipart, 3 we examined progression-free survival with nivolumab versus chemotherapy among patients high (≥10 mutations per megabase).
Abstract KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) comutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine efficacy PD-1 inhibitors these subgroups. Objective response rates to blockade differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) (P < 0.001) Stand Up To Cancer (SU2C) cohort (174 patients) with LUAC patients treated nivolumab CheckMate-057 phase III...
CheckMate 568 is an open-label phase II trial that evaluated the efficacy and safety of nivolumab plus low-dose ipilimumab as first-line treatment advanced/metastatic non-small-cell lung cancer (NSCLC). We assessed association with programmed death ligand 1 (PD-L1) expression tumor mutational burden (TMB).Two hundred eighty-eight patients previously untreated, recurrent stage IIIB/IV NSCLC received 3 mg/kg every 2 weeks 6 weeks. The primary end point was objective response rate (ORR) in 1%...
Therapeutic options for the treatment of an increasing variety cancers have been expanded by introduction a new class drugs, commonly referred to as checkpoint blocking agents, that target host immune system positively modulate anti-tumor response. Although efficacy these agents has linked pre-existing level tumor infiltrate, it remains unclear why some patients exhibit deep and durable responses while others do not benefit. To examine influence genetics on state, we interrogated...
MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C B viral infection. This study aimed to explore epigenetic regulation of miR-122 human HCC cells examine the effect virus (HCV) (HBV). We performed microRNA microarray analysis identified as most up-regulated miRNA (6-fold) treated with 5′aza-2′deoxycytidine (5-Aza-CdR, DNA methylation inhibitor) 4-phenylbutyric acid (PBA, histone...
// Kyoungsub Song 1 , Hyunjoo Kwon Chang Han Jinqiang Zhang Srikanta Dash Kyu Lim 2 Tong Wu Department of Pathology and Laboratory Medicine, Tulane University School New Orleans, LA, USA Biochemistry, College Cancer Research Institute Infection Signaling Network Center, Chungnam National University, Daejeon, Korea Correspondence to: Wu, e-mail: twu@tulane.edu Keywords: CD133, cancer stem cells, glycolysis, miR-122 Received: March 13, 2015 Accepted: September 23,...
miRNAs have recently been implicated in hepatocarcinogenesis, although the actions and mechanisms of individual remain incompletely understood. We examined biological functions molecular miR-185 hepatocellular carcinoma (HCC). The expression is decreased human HCC tissues compared with nonneoplastic liver parenchyma. Quantitative RT-PCR showed a reduction cells primary hepatocytes. overexpression inhibited cell proliferation invasion vitro prevented tumor growth SCID mice. DNMT1 3′...
MiR-17-92 cluster is an oncogenic miRNA that implicated in several cancers, although its role hepatocarcinogenesis has not been clearly defined. In this study, we show the miR-17-92 highly expressed human hepatocellular carcinoma (HCC) tissues compared to non-tumorous liver by RT-PCR and situ hybridization analyses. Increased expression HCC was further confirmed analysis of RNA-sequencing data 319 patients available from Cancer Genome Atlas (TCGA) Data Portal...
Background and Aims Yes‐associated protein (YAP) plays an important role in hepatocarcinogenesis, although the potential of YAP non‐neoplastic liver diseases remains largely unknown. We report herein that Kupffer cells (KCs) enhances production proinflammatory cytokines promotes development nonalcoholic steatohepatitis (NASH). Our data show expression is significantly increased KCs wild‐type mice fed a high‐fat diet (HFD). Approach Results generated with macrophage/monocyte‐specific deletion...
Functions of transforming growth factor-β (TGF-β) in the liver vary depending on specific cell types and their temporal response to TGF-β during different stages hepatocarcinogenesis (HCG). Through analysis tumor tissues from hepatocellular carcinoma (HCC) patients, we were able cluster hepatic epithelial cell-derived gene signatures association with distinct clinical prognoses. To delineate role signaling HCC development, used an experimental system which tumor-initiating hepatocytes (TICs)...
Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from Anti-PD-1 Response Prediction DREAM Challenge, a crowdsourced initiative that enabled assessment predictive models by using data two randomized controlled clinical trials (RCTs) ICIs in first-line metastatic NSCLC.
miR-17-92 is an oncogenic miRNA cluster implicated in the development of several cancers; however, it remains unknown whether able to regulate cholangiocarcinogenesis. This study was designed investigate biological functions and molecular mechanisms cholangiocarcinoma. In situ hybridization quantitative RT-PCR analysis showed that highly expressed human cholangiocarcinoma cells compared with nonneoplastic biliary epithelial cells. Forced overexpression or its members, miR-92a miR-19a,...
Recent evidence has suggested an important role of miRNAs in liver biology and diseases, although the implication cholangiocarcinoma remains to be defined further. This study was designed examine biological function molecular mechanism miR-101 cholangiocarcinogenesis tumor progression. In situ hybridization quantitative RT-PCR were performed determine expression human tissues cell lines. Compared with noncancerous biliary epithelial cells, is decreased 43.5% specimens all three lines used...
Tumor mutational burden (TMB) has emerged as a clinically relevant biomarker that may be associated with immune checkpoint inhibitor efficacy. Standardization of TMB measurement is essential for implementing diagnostic tools to guide treatment.Here we describe the in-depth evaluation bioinformatic analysis by whole exome sequencing (WES) in formalin-fixed, paraffin-embedded samples from phase III clinical trial.In CheckMate 026 trial, was retrospectively assessed 312 patients non-small-cell...
Abstract Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group PGE2, leading to its inactivation. Therefore, 15-PGDH induction may offer strategy treat cancers are driven by such as human cholangiocarcinoma. Here, we report omega-3 polyunsaturated fatty acids (ω-3 PUFA) upregulate expression inhibiting miR-26a and miR-26b, thereby contributing ω-3...
Transforming growth factor β (TGFβ) is a multifunctional cytokine which importantly implicated in hepatocarcinogenesis. The current study provides novel evidence that TGFβ upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R, EGFR, PDGFβR, and FGFR1 human hepatocellular carcinoma (HCC) cells. This, turn, sensitized HCC cells to individual cognate RTK ligands, leading cell survival. Our data showed TGFβ-mediated increase sensitivity led evasion apoptosis...
Background and Aims Cholangiocarcinoma (CCA) is a highly malignant epithelial tumor of the biliary tree with poor prognosis. In current study, we present evidence that histone‐lysine methyltransferase G9a up‐regulated in human CCA enhances cell growth invasiveness through regulation Hippo pathway kinase large suppressor 2 (LATS2) yes‐associated protein (YAP) signaling pathway. Approach Results Kaplan‐Meier survival analysis revealed high expression associated prognosis patients. experimental...
Shotgun proteomics has been widely used to identify histone marks. Conventional database search methods rely on the "target-decoy" strategy calculate false discovery rate (FDR) and distinguish true peptide-spectrum matches (PSMs) from ones. This a caveat of inaccurate FDR caused by small data size To address this challenge, we developed tailored strategy, named "Comprehensive Histone Mark Analysis (CHiMA)." Instead target-decoy-based FDR, method uses "50% matched fragment ions" as key...
Recent studies have demonstrated the implication of long noncoding RNAs (lncRNAs) in a variety physiological and pathological processes. However, majority lncRNAs are functionally unknown. The current study describes that lncRNA MALAT1 regulates TGF-β/Smad signaling pathway through formation lncRNA-protein complex containing Smads, SETD2 PPM1A. Our data show this lncRNA-proteins facilitates dephosphorylation pSmad2/3 by providing interaction niche for their specific phosphatase PPM1A, thus...