A5109476106- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS Research and Interventions
- Monoclonal and Polyclonal Antibodies Research
- HIV-related health complications and treatments
- Lymphatic System and Diseases
- Immune Cell Function and Interaction
- Vascular Malformations and Hemangiomas
- Opioid Use Disorder Treatment
- Prenatal Substance Exposure Effects
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Migration, Health and Trauma
- HIV, Drug Use, Sexual Risk
- Alcoholism and Thiamine Deficiency
- Melanoma and MAPK Pathways
- Torture, Ethics, and Law
- Lymphatic Disorders and Treatments
University of California, San Francisco
2022-2025
Parker Institute for Cancer Immunotherapy
2020-2023
Immune checkpoint inhibitors (ICIs), including CTLA-4- and PD-1-blocking antibodies, can have profound effects on tumor immune cell infiltration that not been consistent in biopsy series reported to date. Here, we analyze seven molecular datasets of samples from patients with advanced melanoma (N = 514) treated ICI agents investigate clinical, genomic, transcriptomic features anti-PD-1 response cutaneous melanoma. We find prior anti-CTLA-4 therapy is associated differences individual gene,...
Summary SARS-CoV-2 T cell response assessment and vaccine development may benefit from an approach that considers the global landscape of human leukocyte antigen (HLA) proteins. We predicted binding affinity between 9-mer 15-mer peptides peptidome for 9,360 class I 8,445 II HLA alleles, respectively. identified 368,145 unique combinations peptide-HLA complexes (pMHCs) with a less than 500nM, observed significant overlap pMHCs. Using simulated populations derived worldwide frequency data, we...
Abstract Background Fentanyl use leads to increased opioid tolerance in people with disorder, complicating management of withdrawal syndrome. While accepted as gold standard, methadone and buprenorphine may be insufficient treat acute withdrawal. Short-acting full agonist opioids (SAFAO) improve treatment the care setting. Aim Characterize SAFAO syndrome for inpatients. Setting Urban safety-net hospital. Participants Inpatients disorder. Program Description Addiction Consult Team offers...
Abstract Introduction: Delineating antiviral T-cell responses to SARS-CoV-2 may shed light on the heterogeneity of clinical outcomes and inform vaccine or therapeutic approaches. Viral antigens can be predicted using computational tools that calculate binding affinity between viral peptides antigen presentation machinery. However, in order account for role host genetics diversity responses, this analysis must performed with consideration global human leukocyte (HLA) proteins responsible...
Introduction This research, through the analysis of case-law Inter-American Court Human Rights (IACtHR), seeks to shed light on nexus between families missing' claims, their agency and State compliance with reparations. The IACtHR has a unique follow-up system in area reparations, where victims can directly address judges during hearings. paper suggests that victims' participation - before after judgment- pervades legal rigidity international jurisdictions contributes better understanding...
OBJECTIVES/GOALS: Contingency management (CM), wherein patients earn prizes for behavior change, is the gold-standard reducing stimulant misuseand has been shown to improve medication adherence.We aim describe feasibility, acceptability, and effectiveness of CM reduce use optimize ART adherence in Women’s HIV primary care. METHODS/STUDY POPULATION: Using ADAPT-ITT model adapting evidence-based interventions, we implemented CoMBostudy at Ward 86 Clinic San Francisco General Hospital....
<sec> <title>BACKGROUND</title> Amongst people living with HIV, stimulant use disorder (StUD) has been linked medication non-adherence and mortality. Contingency management (CM) is a strategy incentivizing measurable behavior change that recommended as first-line treatment for StUD can support antiretroviral therapy (ART) adherence. However, CM not widely implemented, in part due to feasibility concerns. While reductions substance short of abstinence improve health outcomes, programs...