A5101495192- Influenza Virus Research Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Pelvic floor disorders treatments
- Phytochemistry and biological activity of medicinal plants
- Respiratory viral infections research
- Phytochemistry and Biological Activities
- Cancer Treatment and Pharmacology
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Microbial Natural Products and Biosynthesis
- Immune Response and Inflammation
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Anorectal Disease Treatments and Outcomes
- Toxin Mechanisms and Immunotoxins
- Cancer-related molecular mechanisms research
- Urinary and Genital Oncology Studies
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Fungal Biology and Applications
- Colorectal and Anal Carcinomas
Hebei General Hospital
2016-2025
Sichuan University
2025
West China Second University Hospital of Sichuan University
2025
Shanghai Children's Medical Center
2025
Kunming Medical University
2025
Hunan Agricultural University
2012-2025
Nanjing Medical University
2024
Handan College
2024
Guilin University
2024
Guilin University of Electronic Technology
2024
Avian Flu in Ferrets A recent outbreak of avian H7N9 influenza humans eastern China has been closely monitored for any evidence human-to-human transmission and its potential sparking a pandemic. Zhu et al. (p. 183 , published online 23 May) examined the behavior virus ferret, mammalian model human influenza. The was excreted by ferrets could be transmitted readily contact but displayed limited capacity airborne infectivity. pathology is similar to H1N1, it seems that factors other than...
3536 Background: Bevacizumab (BV) prolongs overall survival and progression-free when added to standard chemotherapy for patients with metastatic colorectal cancer (mCRC). BRiTE is a large, community-based observational registry of mCRC receiving BV plus first-line chemotherapy. Safety efficacy information in unselected are collected. Chemotherapy regimen choice at the physician’s discretion. Methods: To facilitate evaluate enrollment typical population, eligibility criteria were minimized....
Oryzaeins A–D (<b>1</b>-<b>4</b>), four new isocoumarin derivatives, along with five known ones (<b>5</b>-<b>9</b>) were isolated from solid cultures of an endophytic fungus <i>Aspergillus oryzae</i>. Their structures elucidated by detailed spectroscopic analysis and comparison reported data related derivatives. Among them, compounds <b>1</b> <b>2</b> represent the first examples isocoumarins possessing unusual 2-oxopropyl group a rare 3-hydroxypropyl group. Compounds displayed moderate...
3535 Background: Bevacizumab (BV) prolongs overall survival and progression-free when added to standard chemotherapy in patients (pts) with metastatic colorectal cancer (mCRC). BRiTE is a large, community-based observational registry of pts mCRC receiving BV plus first-line (CT). Incidence rate, temporal pattern, potential risk factors associated gastrointestinal perforation (GIP) were explored. Methods: Baseline patient characteristics (BC), including prospectively identified for GIP,...
We tested if vagus nerve stimulation (VNS) would prevent gut injury, mesenteric lymph toxicity, and systemic multiple organ dysfunction syndrome following trauma-hemorrhagic shock (T/HS). Four groups of experiments were performed. The first whether VNS (5 V for 10 min) protect against T/HS-induced increases in lung permeability as well neutrophil priming. In the second experiment, was collected from rats subjected to T/HS or trauma-sham with without then injected into naive mice assess its...
The novel re-assortment A influenza H7N9 (nrH7N9) emerged in humans the Shanghai and surrounding provinces of China late February early March. Three infected index patients developed severe viral pneumonia with acute respiratory distress syndrome (ARDS) resulted fatal outcome. As 15 April 2013 there were reported 60 confirmed nrH7N9 infections 13 fatalities. Human-to-human transmission has not been observed, but zoonotic from birds to appear be associated live poultry markets. Elderly...
Segmentectomy has the advantage of less complications, but might have lymph node sampling and higher risk recurrence. We aimed to compare treatment outcome between two surgical options, explore effect regional removal on prognostic difference.We retrospectively analyzed data stage I non-small cell lung cancer (NSCLC) (≤3 cm in size) patients who underwent either segmentectomy, or lobectomy, collected from Surveillance, Epidemiology End Results (SEER) database, 2003 2013. The primary...
4036 Background: While BV prolongs OS when used with standard 1 st - or 2 nd -line chemotherapy (CT) in mCRC, no data exist on the effects of BBP. A previous report from BRiTE showed favorable median (27.1 mo, 95% CI 24.8-NE), line PFS (median 10.1 CI:9.7–10.4) comparable to historical mCRC trials, suggesting significant impact post-progression survival OS. This exploratory analysis evaluates association various pre- and post-treatment variables BRiTE. Methods: Pt population methods have...
It is well documented that the gut injury plays a critical role in development of systemic inflammation and distant organ conditions associated with splanchnic ischemia. Consequently, understanding mechanisms leading to important. In this context, recent work suggests protective for intestinal mucus layer an injury-inducing luminal pancreatic proteases. Thus, we explored barrier function by observing how removal affects ischemia-reperfusion-mediated rats as potential proteases pathogenesis...
Recent studies have shown that mesenteric lymph plays a very important role in the development of multiple-organ dysfunction syndrome under critical conditions. Great efforts been made to identify biologically active molecules lymph. We used trauma-hemorrhagic shock (T/HS) model and superior artery occlusion (SMAO) model, representing global localized intestinal ischemia-reperfusion insult, respectively, investigate free fatty acids (FFAs) cytotoxicity rats. Lymph was collected before,...
Introduction Lung cancer has a higher incidence and mortality rate than other cancers, especially non-small cell lung (NSCLC), accounting for 85% of the cases. The role circDENND4C/miR-200b/matrix metalloproteinase-9 (MMP-9) regulatory axis in NSCLC remains largely unknown. Methods lines were used to examine expression circDENND4C, miR-200b, MMP-9 via qRT-PCR or Western blot. target relationship was examined by RNA fluorescence situ hybridization (RNA-FISH), immunofluorescence (IF),...
The overuse of antibiotics in poultry farming has led to the emergence multidrug-resistant pathogens, posing severe threats animal health and public safety. Salmonella Pullorum (S. Pullorum), a host-specific pathogen targeting poultry, causes high mortality chicks disrupts intestinal health. This study evaluated protective effects Bifidobacterium bifidum postbiotics (BbP) against S. infection, focusing on their mechanisms regulating pyroptosis, restoring barrier function, modulating gut...
The aim of this retrospective clinical study is to assess outcomes and patient satisfaction between laparoscopic lateral suspension (LLS) with mesh high uterosacral ligament (LHUS) for apical prolapse or without anterior prolapse. Patients who underwent LLS LHUS from 2019 2023 at the Second West China Hospital Sichuan University were enrolled in study. objective evaluated on basis anatomical success rate according Pelvic Organ Prolapse Quantification System (POP-Q). subjective assessed using...
This study aimed to explore family management style (FMS) after palliative surgery in children with complex congenital heart disease (CCHD) and evaluate its influence on their outcomes. A cross-sectional survey was conducted among 252 families of CCHD who underwent at our center. The Family Management Measure used investigate FMS, the outcomes different FMSs were analyzed. Cluster analysis employed classify into distinct groups. cluster identified four FMSs, namely, Active Collaborative...
4026 Background: BV prolongs overall survival (OS) and progression-free (PFS) when added to CT for 1st- line (FL) 2nd-line treatment (tx) of pts with mCRC. Subgroup analyses (ages ≥65 vs <65) in the pivotal trials (RCTs) + showed significant improvement PFS OS without increased toxicity. The BRiTE study previously comparable safety effectiveness (PFS, 1-yr rate) <65. This report further delineates clinical outcomes following elderly subgroups: 65–74, >75 >80. Methods: Pts methods have been...
BACKGROUND Hemorrhagic shock is known to disrupt the gut barrier leading end-organ dysfunction. The vagus nerve can inhibit detrimental immune responses that contribute organ damage in hemorrhagic shock. Therefore, we explored whether stimulation of protect and recover lung permeability trauma-hemorrhagic (THS). METHODS Male Sprague-Dawley rats were subjected left cervical at 5 V for 10 minutes. right internal jugular femoral artery cannulated blood withdrawal pressure monitoring,...