A5009511013- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Salivary Gland Disorders and Functions
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Renal and Vascular Pathologies
- Lipoproteins and Cardiovascular Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic function and diabetes
- Sarcoidosis and Beryllium Toxicity Research
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Cytomegalovirus and herpesvirus research
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Weifang People's Hospital
2024-2025
Ningxia University
2025
Jilin Agricultural University
2025
Jilin University
2025
Ministry of Ecology and Environment
2024
Jilin University of Chemical Technology
2024
Academy of Medical Sciences
2014
Novem (Netherlands)
2007
Significance Statement Coronavirus disease 2019 (COVID-19) is a new contagious disease. Previous studies reported AKI with varying results regarding the incidence, severity, and outcomes. This study provides detailed clinical data of 81 patients critically ill COVID-19 prolonged course, renal pathologic findings from ten deceased in single intensive care unit Wuhan, China. The incidence was 50.6%, 41.5% cases AKIs were Kidney Disease Improving Global Outcomes (KDIGO) stage 3. primary...
Renal tubular epithelial cells are one of the high energy-consuming cell types, which mainly depend on mitochondrial energy supply. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that involved in alcohol metabolism and oxidative ATP production; however, its function homoeostasis acute kidney injury (AKI) unclear. Here, we found ALDH2 expression was predominantly decreased cisplatin or maleic acid (MA) models both vivo vitro. knockout (KO) mice exhibited exacerbated impairment apoptosis...
Optimizing the installation parameters of photovoltaic panels in a array to reduce dust accumulation, thereby enhancing their power generation, is crucial research topic construction solar stations desert regions. Utilizing series wind tunnel experiments on comprising four equally sized panels, this study assessed how variations tilt angle, mounting height, spacing, and incoming flow direction influence both accumulation mass particle size distribution array. The results indicate that first...
Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity patients with IgAN remain controversial. Concentrations of 147 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations clinicopathological features evaluated. Serum levels [9.20 (7.70–10.60) pg/mL vs. 6.04 (5.11–7.23) pg/mL, P < 0.0001] higher than that subjects. Receiver operating...
Abstract Aim To retrospectively investigate the features of renal involvements in patients with primary Sjögren's syndrome ( pSS ) biopsy results. Methods A total 2096 inpatients at Peking Union Medical College Hospital China from 2005 to 2015 were identified. Patients biopsy‐proven involvement SS ‐renal) and matched controls ‐only) recruited. The clinical pathologic as well treatments outcomes systematically analyzed. Results One hundred three nephritis (inpatients had involvement....
Renal thrombotic microangiopathy (TMA) is an uncommon pathological finding in lupus nephritis (LN), and its clinical significance remains to be defined.Twenty-four patients with (LN) renal TMA were selected from a retrospective review of 677 biopsy-proven LN patients, compared 48 controls without (1:2 ratio) matched according demographics treatments.Renal was noted 3.5% kidney biopsies LN. associated higher prevalence anti-Ro (45.8% vs 18.8%; p = 0.016), Systemic Lupus Erythematosus Disease...
To investigate the mediating effect of social isolation on relationship between stigma and work ability in young middle-aged stroke patients. From May 2022 to 2024, a survey was conducted patients visiting neurology department tertiary hospital Weifang. The utilized General Information Questionnaire, Rankin Scale, Isolation Stigma Scale for Stroke Patients, Work Ability Scale. scores ability, isolation, among were 44.23 ± 12.72, 46.27 5.17, 43.37 4.48, respectively. There positive...
Aim Orthopedic surgery patients frequently delay early rehabilitation due to postoperative discomfort. This is especially true for younger with anterior cruciate ligament injuries who are eager return sports after discharge. Despite the recognized benefits of rehabilitation, a standardized protocol determining safe weight-bearing timelines post-ACL reconstruction lacking. study aims evaluate effectiveness an Intelligent Weight-Bearing Rehabilitation Robot in improving recovery outcomes these...
Objective To investigate the value of repeat renal biopsy in treatment and prognosis nephrotic syndrome(NS)and acute kidney injury(AKI)following immunosuppressive therapy patients with lupus nephritis(LN).Methods A retrospective analysis was conducted for clinicopathological data follow-up records LN undergoing at Peking Union Medical College Hospital from January 1,2009 to December 31,2021.Results total 76 patients(55 females,72.4%)were included this study,with mean age first...
Objective. To investigate the renal protective effects of early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin inhibitors (RASI) in systemic lupus erythematosus (SLE) patients antiphospholipid-associated nephropathy (aPLN). Methods. Medical data 57 SLE biopsy-proven aPLN were analyzed. Early RAAS was defined as administration RASI within 3 months after kidney biopsy and continued for ≥ 12 months. Results. There no significant difference demographic data,...
Objective. To investigate the characteristics and outcomes of patients with systemic lupus erythematosus (SLE)–associated thrombotic microangiopathy (TMA) based on their ADAMTS13 inhibitor profiles. Methods. The medical data 31 SLE clinically diagnosed TMA were analyzed. activity measured in all patients. Results. was attributable to active 19 severe deficiency detected 6 them. Patients (n = 6) exhibited a lower platelet count (7.3 ± 5.1 vs 25.0 17.8 × 10 9 /l, p 0.005) more prevalent...
Renal gluconeogenesis is markedly promoted in patients with type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains largely unknown. found to be negatively regulated by insulin. T2DM characterized chronic and subacute inflammation; inflammation has been well recognized induce insulin resistance. Therefore, this study aimed investigate whether enhanced renal was partially due inflammation-mediated If so, inhibitor could reverse such change. Diabetic db/db mice db/m were...
<i>Background:</i> Mice with deletion of Gsα in renin-producing cells (RC/FF mice) have been shown to greatly reduced renin production and lack responsiveness secretion acute stimuli. In addition, young RC/FF mice are hypotensive a vasopressin-resistant concentrating defect. the present study we determined long-term effect on renal function, blood pressure, pathology this low diuretic mouse model. <i>Methods Results:</i> Urine osmolarity was decreased all age groups....
IgG4-related disease is a new entity, but little attention was drawn to urinary system involvement besides nephritis or nephropathy. Here, we described clinical, radiological, and pathological manifestations of (IgG4-RUD) assess its treatment responses. We conducted retrospective study enrolling 65 IgG4-RUD patients from an (IgG4-RD) cohort the Peking Union Medical College Hospital. Clinical, laboratory, data were collected, response immunosuppressants analysed. interstitial (TIN, 32.3%),...