A5101563270- Systemic Lupus Erythematosus Research
- IgG4-Related and Inflammatory Diseases
- Salivary Gland Disorders and Functions
- Rheumatoid Arthritis Research and Therapies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Gastrointestinal disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Platelet Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- T-cell and B-cell Immunology
- Retinal and Optic Conditions
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Diabetes and associated disorders
- Peripheral Neuropathies and Disorders
- Venous Thromboembolism Diagnosis and Management
- Mycobacterium research and diagnosis
- Inflammatory Myopathies and Dermatomyositis
- Reproductive System and Pregnancy
- Vascular Malformations and Hemangiomas
Henan Cancer Hospital
2025
Zhengzhou University
2025
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
National Clinical Research
2021-2024
Ministry of Science
2024
Ministry of Education of the People's Republic of China
2014-2024
Second Affiliated Hospital of Nanjing Medical University
2024
National Clinical Research Center for Digestive Diseases
2020-2024
Academy of Medical Sciences
2021-2023
To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjögren's syndrome (SS).The database the International Collaborative Clinical Alliance (SICCA), a registry patients with symptoms possible SS as well those obvious disease, was used for present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among 1,726 exhibiting any pattern sialadenitis, we compared diagnoses...
To characterize the clinical features of IgG4-related disease (IgG4-RD) in China.A prospective cohort study IgG4-RD was carried out Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed were enrolled.A total 118 patients enrolled, including 82 males 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset lacrimal gland swelling (38/32.2%). A range organs involved: 77 (65.3%) had lymphadenopathy, 76 (64.4%) sialadenitis, 60 (50.8%)...
This randomized, controlled clinical trial aims to compare the efficacy and safety of glucocorticoid combined with MMF monotherapy for patients IgG4-related disease. Sixty-nine newly diagnosed disease were randomly divided into two groups (35 in Group I 34 II). Patients received (0.6–0.8 mg/(kg·day) tapered gradually); II therapy (1–1.5 g/day). All followed up at 1, 3, 6 12 months. The primary endpoint was response rate months secondary endpoints relapse, remission adverse reactions. shared...
Abstract Aim to evaluate the efficacy and safety of glucocorticoid monotherapy vs combination therapy cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD). 102 newly diagnosed IgG4-RD patients were enrolled assigned 2 groups: Group I was prednisone (0.5–1.0 mg/kg.d, tapered gradually) II CYC (50–100 mg per day). Patients assessed at different periods. Primary end point relapse rate; secondary points included response, remission rate adverse effects. 52 in 50 II. At 1 month, both groups...
Objective The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international data registry and biorepository derived from a multisite observational study of participants in whom genotyping was performed on the Omni2.5M platform who had undergone deep phenotyping using common protocol‐directed methods. aim this to examine genetic etiology syndrome (SS) across ancestry disease subsets. Methods We genome‐wide association analyses SICCA subjects external controls obtained...
Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective this study was to evaluate the prevalence major comorbidities in Chinese rheumatoid patients. We also aimed identify factors associated with these Baseline demographic, clinical characteristics and comorbidity data from RA enrolled Registry rhEumatoiD arthrITis (CREDIT) Nov 2016 August 2017 were presented compared those five other registries across world. Possible related three (cardiovascular...
Objective To determine the number and function of follicular helper T (Tfh) cell subsets in IgG4‐related disease (IgG4‐ RD ). Methods Mononuclear cells from peripheral blood involved tissue patients with IgG4‐ were assessed for Tfh their subsets, levels B lymphoma 6 (Bcl‐6), lymphocyte–induced maturation protein 1 ( BLIMP ‐1), interleukin‐21 IL ‐21) messenger RNA mRNA Immunohistochemical immunofluorescence techniques used to assess location ‐21, Bcl‐6, CD 4+ CXCR 5+ cells. Furthermore,...
Abstract Objectives To study the impact of sex on clinical presentation IgG4-related disease (IgG4-RD). Methods We prospectively enrolled 403 newly diagnosed IgG4-RD patients. compared demographic features, manifestations, organ involvement, laboratory tests and treatment outcomes between female male The organs involved were divided into superficial (salivary glands, lacrimal orbit, sinus skin) internal (all other organs). patients treated with glucocorticoids or without additional...
Background Striking similarities have been found between coronavirus disease 2019 (COVID-19) and anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-related dermatomyositis, implying a shared autoinflammatory aberrance. Herein, we aim to investigate whether the anti-MDA5 Ab is present in COVID-19 correlates with severity adverse outcome of patients. Methods Findings We retrospectively recruited 274 adult inpatients this study, including 48, 164, 62 cases deaths, severe,...
Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles primary Sjögren's syndrome (pSS) remain unclear. We aimed to reveal potential neutrophils neutrophil extracellular traps (NETs) pSS.pSS patients were enrolled markers measured plasma labial glands using ELISA immunofluorescence. The gene signatures assessed by RNA-Seq RT-PCR. Reactive oxygen species (ROS), mitochondrial ROS (MitoSOX) production, JC-1 flow...
<h3>Objective</h3> To determine whether the Sjögren9s syndrome B (SSB)-positive/Sjögren9s A (SSA)-negative antibody profile is associated with key phenotypic features of SS. <h3>Methods</h3> Among registrants in International Collaborative Clinical Alliance (SICCA) possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent features. We fitted logistic regression models to explore association between and each SS feature, controlling for potential...
Objective. The impact of pregnancy on lupus activity has been controversial especially in Chinese women. Research looking at predictive factors this population are sparse. aim study was therefore twofold: to determine the frequencies abnormal outcomes a cohort and identify clinical laboratory predicting adverse fetal maternal women with systemic erythematosus. Study design. Data 111 pregnancies 105 erythematosus (SLE) patients from January 1990 December 2008 Peking Union Medical College...
The aim of this study was to assess the outcomes remission induction in patients with IgG4-related disease (IgG4-RD) our cohort, and investigate characteristics, prognosis, risk factors failed induction. We prospectively enrolled 215 newly diagnosed IgG4-RD, who were initially treated glucocorticoid (GC) alone or combination immunosuppressive agents (IM), had at least 6 months follow up. therapeutic goals defined as fulfilling each following after 6-month stage: (1) ≥ 50% decline IgG4-RD...
Abstract Introduction IgG4-related disease (IgG4-RD) is a multisystem-involved autoimmune disease. Abnormally activated and differentiated B cells may play important roles. Regulatory (Breg) are newly defined cell subgroups with immunosuppressive functions. In this study, we investigated the differences of subsets, expressions co-stimulatory molecules on cells, function Breg in patients IgG4-RD, primary Sjögren’s syndrome (pSS) as well healthy controls (HC). Methods Newly diagnosed IgG4-RD...
Peking Union Medical College Hospital (PUMCH) has started a single-center right heart catheterization (RHC)-based pulmonary arterial hypertension (PAH) study in systemic lupus erythematosus (SLE) since 2006. The baseline characteristics of these patients were described and the risk factor for PAH was identified. demographic, clinical, laboratory, treatment SLE with when they registered collected as data. A case-control conducted by taking admitted SLE-non-PAH adjusted age gender 4:1 ratio...
To investigate clinical and radiological features of IgG4-related disease (IgG4-RD) patients with intrathoracic involvement. A prospective cohort study was performed IgG4-RD were enrolled from January 2011 to March 2015 in Peking Union Medical College Hospital, which the characteristics involvement summarized. Out total 248 cases IgG4-RD, 87 had lesions, including 58 male 29 female cases, average age 54.19 ± 13.80 years. Hilar mediastinal lymphadenopathy most common manifestations disease,...
To investigate the clinical features of Behçet's disease (BD) complicated with thrombosis. Medical records patients BD at Peking Union College Hospital from 1993 to 2013 were reviewed identify Of 766 BD, 93 (16 female and 77 male) developed The most common thrombosis was extremity vein (86.0%), including deep (n = 78) superficial thrombophlebitis 4). other types associated in descending frequency order were: vena cava (30.1%), pulmonary thromboembolism (15.1%), cerebral venous (CVT) (12.9%),...
Objectives To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) a large cohort SLE Treatment Research group (CSTAR) database. Methods A prospective cross-sectional study was conducted based on data from CSTAR registry. Serositis defined according to 1999 revised American College Rheumatology (ACR) criteria for – that is, pleuritis/pleural effusion and/or pericarditis/pericardial detected by echocardiography,...