A5020286265- Viral-associated cancers and disorders
- IgG4-Related and Inflammatory Diseases
- Parvovirus B19 Infection Studies
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Histiocytic Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- Gastrointestinal Tumor Research and Treatment
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- CNS Lymphoma Diagnosis and Treatment
- Occupational and environmental lung diseases
- Lymphoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Tumors and Oncological Cases
- Polyomavirus and related diseases
- Ear and Head Tumors
- Cervical Cancer and HPV Research
- Metastasis and carcinoma case studies
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
Kanazawa Medical Center
2021-2025
National Hospital Organization
2019-2025
Kanazawa Medical University
2013-2023
Kanazawa Medical University Hospital
2003-2021
Fukuyama Cardiovascular Hospital
2019
Industrial Research Institute of Ishikawa
2019
Kanazawa University
2018
IgG4-related disease (IgG4RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4RD may be present in certain proportion of patients with wide variety diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, pseudotumor. Although...
To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjögren's syndrome (SS).The database the International Collaborative Clinical Alliance (SICCA), a registry patients with symptoms possible SS as well those obvious disease, was used for present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among 1,726 exhibiting any pattern sialadenitis, we compared diagnoses...
IgG4-related disease is a new classification established in Japan the 21st century. Patients with display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids. Since IgG4 overexpression also observed other disorders, it necessary diagnose carefully correctly. We therefore sought determine cutoff values for serum IgG4/IgG IgG4+/IgG+ tissue diagnostic disease. Methods . retrospectively analyzed concentrations ratio cell...
Abstract Castleman disease (CD) is a rare lymphoproliferative disorder that can be unicentric or multicentric. Multicentric CD (MCD) further subdivided into human herpesvirus type‐8‐associated, POEMS syndrome‐associated, and idiopathic (iMCD). TAFRO syndrome newly identified of unknown etiology characterized by t hrombocytopenia, nasarca, f ever, r eticulin myelofibrosis, renal dysfunction, o rganomegaly. The sometimes regarded as subtype iMCD (TAFRO‐iMCD), whereas without considered “not...
Multicentric Castleman's disease (MCD) is a polyclonal lymphoproliferative disorder that manifests as marked hyper-γ-globulinemia, severe inflammation, anemia, and thrombocytosis. Recently, Takai et al. reported new concept, TAFRO syndrome, named from thrombocytopenia, anasarca, fever, reticulin fibrosis, organomegaly. Furthermore, Kojima Japanese MCD cases with effusion thrombocytopenia (Castleman-Kojima disease). Here, we report two of associated pleural effusion, ascites, discuss the...
Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, strategy should be established.Patients who fulfilled comprehensive diagnostic criteria definite disease were started on prednisolone (0.6 mg/kg body weight) dose reduced every two weeks. The subsequent maintenance and need determined individual patients. primary endpoint was complete remission (CR) rate at one year. Secondary endpoints included overall...
Abstract Objectives: To identify useful biomarkers for differentiating between malignant mesothelioma (MM) and reactive mesothelial cells (RMCs). Methods: Formalin-fixed, paraffin-embedded (FFPE) tissues from 34 MM 40 RMC samples were analyzed using immunohistochemistry, the findings compared. Results: Positive markers included insulin-like growth factor 2 messenger RNA binding protein 3 (IMP3), glucose transporter 1 (GLUT1), epithelial membrane antigen (EMA), CD146, which showed...
Castleman disease is a polyclonal lymphoproliferative which clinically classified into unicentric (UCD) and multicentric (MCD). TAFRO syndrome relatively new concept that partly overlaps with MCD. Due to their rarity, incidence remains unknown. This study investigated the prevalence of UCD, MCD, in Japan using fixed-point observation method based on Ishikawa prefecture. The annual incidences were 309-731, 71-542, 110-502, respectively, yielding rates per million individuals 2.4-5.8, 0.6-4.3,...
A case of adenomatoid tumor the pleura is reported, and its differential diagnosis from benign malignant pleural lesions discussed. small nodule was incidentally found during a thoracic operation in 54‐year‐old woman with esophageal cancer. The patient had no history exposure to asbestos, well sign recurrence 14 months after operation. 7 mm, circumscribed characteristic features tumor. composed an aggregation irregularly shaped tubulocystic spaces fibrous stoma. were lined by flattened...
Amiodarone is a highly effective treatment for supraventricular and ventricular tachyarrhythmia; however, it could be associated with several serious adverse effects, including liver injury.We report the clinical histological features of two contrasting Japanese patients amiodarone-induced reversible irreversible hepatotoxicity. One patient hepatotoxicity showed cirrhosis during amiodarone died hepatic failure; other patient, who had hepatotoxicity, course function imaging after...
Background: Oxidative stress plays key roles in the progression of lung adenocarcinoma. Recently, we reported that peroxiredoxin 4 (PRDX4), an antioxidant enzyme, can be a prognostic marker adenocarcinoma (LUAD). In present study, aimed to further investigate relationship among PRDX4 expression, epidermal growth factor receptor (EGFR) mutations and cell proliferation LUAD. Methods: The expression was immunohistochemically analyzed EGFR mutation status examined 127 paraffin-embedded human...
Background Arterial/aortic tertiary lymphoid organs (ATLOs), characterized by germinal centers, control local arterial immune responses. T follicular helper cells (Tfh), resident in regulate immunoglobulin production and center development. They consist of Tfh1, Tfh2, Tfh17 subsets. regulatory (Tfr) possess suppressive functions as migrate into centers. Immunoglobulin G4 (IgG4)–related diseases manifest vascular lesions frequently formed inflammatory aneurysms (IgG4‐related abdominal aortic...
Rationale: TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe syndrome-like systemic symptoms during clinical course juvenile-onset Sjögren's in 32-year-old woman. Patient concerns: The patient was admitted due to dyspnea, polyarthralgia, generalized edema. She had been diagnosed with at age 14 years, based on histopathological...