A5056449434- RNA Research and Splicing
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Skin Protection and Aging
- RNA and protein synthesis mechanisms
- Connexins and lens biology
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- IgG4-Related and Inflammatory Diseases
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Pancreatic and Hepatic Oncology Research
- Mesenchymal stem cell research
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Ionic liquids properties and applications
- MicroRNA in disease regulation
- DNA Repair Mechanisms
Kanazawa Medical University
2016-2025
Kanazawa Medical University Hospital
2015-2025
Medical Research Institute
2014-2018
MED Institute
2018
Kanazawa University
1994-2016
Molecular Oncology (United States)
2008-2016
Tohoku Medical and Pharmaceutical University Hospital
2015
Kure Medical Center
2015
National Hospital Organization
2015
Kyoritsu Women's University
2008-2009
IgG4-related disease (IgG4RD) is a novel clinical entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration IgG4-positive plasma cells. IgG4RD may be present in certain proportion of patients with wide variety diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, pseudotumor. Although...
Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, which diabetic nephropathy leading cause. Endothelial-to-mesenchymal transition (EndMT) has emerged as one most important origins matrix-producing fibroblasts. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been introduced into market antidiabetes drugs. Here, we found that DPP-4 inhibitor linagliptin ameliorated in mice without altering blood glucose levels associated with inhibition EndMT and...
Objectives: Prostate cancer stem cells (CSCs) play an important role in cell survival, proliferation, metastasis, and recurrence; thus, removing CSCs is for complete removal. However, the mechanisms underlying CSC functions remain largely unknown, making it difficult to develop new anticancer drugs targeting CSCs. Herein, we aimed identify novel factors that regulate stemness predict prognosis. Methods: We reanalyzed 2 single-cell RNA sequencing data of prostate (PCa) tissues using Seurat....
Abstract A toxic endocrine disruptor, 4-n-nonylphenol, was degraded using a well-known TiO2 and visible-light-driven BiVO4 photocatalyst under irradiation from solar simulator. The degradation rates for both are comparable in air-saturated solution though surface area of is much smaller than that TiO2. This fact indicates has great ability to degrade alkylphenols wastewater light.
Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be in microRNA expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a substrate angiotensin-converting enzyme (ACE). Here, we found that AcSDKP inhibited the EndMT exhibited fibrotic were associated with FGF receptor-mediated anti-fibrotic program....
Abstract N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous antifibrotic peptide. We found that suppression of AcSDKP and induction dipeptidyl peptidase-4 (DPP-4), which associated with insufficient levels microRNA (miR)s in kidneys, were imperative to understand the mechanisms fibrosis diabetic kidneys. Analyzing streptozotocin (STZ)-induced mouse strains, CD-1 mice fibrotic kidneys could be differentiated from less-fibrotic 129Sv by suppressing miRs (miR-29s miR-let-7s), as...
Human Upf1 protein (p), a group 1 RNA helicase, has recently been shown to function in nonsense-mediated mRNA decay (NMD) mammalian cells. Here, we demonstrate that the estimated 3 × 106 copies of hUpf1p per exponentially growing HeLa cell are essentially equally distributed among polysomal, subpolysomal, and ribosome-free fractions. We also binds is phosphoprotein harboring phosphoserine phosphothreonine. phosphorylated highest extent when polysome-associated lowest ribosome free. find...
Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially hippocampus, chronic fatigue syndrome (CFS) patients. However, its pathophysiologic mechanisms are unclear part due to lack of an applicable animal model. We established a murine model by six repeated injections Brucella abortus antigen mice, which was manifested as reduced daily running activity and hippocampal atrophy. Thereafter, resveratrol, polyphenolic activator...
Abstract Ionic liquid is a kind of salt that stays in molten state even at room temperature. It does not vaporize all vacuum and facilitates electrical conductivity to the sample surfaces for observations with scanning electron microscope (SEM). In this study, we used an ionic SEM first time observe fixed human culture cells. The condition cell using wrapping sheets settings were varied elucidate optimized protocol. Compared samples prepared by conventional way, liquid‐treatment gave images...
Background and Purpose The major obstacles to treatment of pancreatic cancer are the highly invasive capacity resistance chemo- radiotherapy. Glycogen synthase kinase 3β (GSK3β) regulates multiple cellular pathways is implicated in various diseases including cancer. Here we investigate a pathological role for GSK3β resistant phenotype Methods Pancreatic cells were examined expression, phosphorylation activity using Western blotting vitro assay. effects inhibition on cell survival,...
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease cause telomere dysfunction, resulting accelerated aging. Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem (iPSCs). In present study, we describe effects of long-term culture on iPSCs, which acquired maintained infinite proliferative potential self-renewal...
Abstract An ultraviolet-B (UV-B)-resistant mutant,uvi1 (UV-B insensitive 1), of Arabidopsis was isolated from 1,280 M1 seeds that had been exposed to ion beam irradiation. The fresh weight ofuvi1 under high-UV-B exposure more than twice the wild type. A root-bending assay indicated root growth less inhibited by UV-B in uvi1 When seedlings were grown white light, dose required for 50% inhibition about 6 kJ m−2for type and 9 m−2 uvi1. irradiated with darkness, 1.5 4 enzyme-linked immunosorbent...
RBM8A (Y14) contains an RNA-binding motif and forms a tight heterodimer with Magoh. The is known to be member of the exon junction complex that on mRNA before export it required for metabolism processes such as splicing, nonsense-mediated decay. Recently, deficient cellular proliferation has been observed in RBM8A- or Magoh-depleted cells. These results prompted us study role cell cycle progression human tumour depletion A549 cells resulted poor survival accumulation mitotic After release...
The biological influence of antidiabetic drugs on cancer cells and diabetic patients has not yet been completely elucidated. We reported that a dipeptidyl peptidase (DPP)-4 inhibitor accelerates mammary metastasis by inducing epithelial-mesenchymal transition (EMT) through the CXCL12/CXCR4/mTOR axis. Metformin shown to inhibit mTOR signaling pathway. In this study, we investigated whether metformin mitigates breast induced DPP-4 via suppression signaling. cultured mouse human cells,...