A5108598938- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Seaweed-derived Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Plant-based Medicinal Research
- Pharmacogenetics and Drug Metabolism
- Biochemical effects in animals
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Flavonoids in Medical Research
- Protein Hydrolysis and Bioactive Peptides
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Synthesis of Organic Compounds
- Neuropeptides and Animal Physiology
- Morinda citrifolia extract uses
- Quinazolinone synthesis and applications
Komatsu (Japan)
2009-2025
Tohoku Medical and Pharmaceutical University
2016-2025
Osaka Women's and Children's Hospital
2024
Mitsui Chemicals (Japan)
2009
University of Shizuoka
2009
Shizuoka Saiseikai General Hospital
2009
University of Mississippi Medical Center
2002-2003
State Street (United States)
2002
Shohoku College
1990-1998
In vitro antifungal activities of naphtoquinone-derivatives, which are constituents Shikon, roots Lithospermum erythrorhizon, were investigated against several fungal pathogens. When the biological activity these compounds was tested fungi, a wide range sensitivity recorded. Shikonin found to have stronger than fluconazole yeast-like fungi: four-fold Candida krusei (minimal inhibitory concentration (MIC); 4 microg/ml) and two-fold (MIC; Saccharomyces cerevisiae, though it showed same potency...
Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially hippocampus, chronic fatigue syndrome (CFS) patients. However, its pathophysiologic mechanisms are unclear part due to lack of an applicable animal model. We established a murine model by six repeated injections Brucella abortus antigen mice, which was manifested as reduced daily running activity and hippocampal atrophy. Thereafter, resveratrol, polyphenolic activator...
We investigated the effects of water and ethyl acetate extracts Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both layer extract fraction 7 decreased HCV cells. Furthermore, demonstrated 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) is active ingredient markedly inhibited infection
From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures these compounds elucidated on basis spectroscopic analysis. Clinopodic C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
Chemical investigation of the aerial parts Atraphaxis frutescens resulted in isolation five 7-methoxyflavonols with pyrogallol B-ring moieties (1–5), a fisetinidol glucoside (13), and benzyl glycoside (18), together 26 known compounds including flavonoids, phenylpropanoid amides, anthraquinone glycosides, lignans, derivative. The principal chemical structural feature isolated was either or catechol moiety, they showed potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. To...
The aim of the present study was to identify inhibitory activity natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Antioxidant evaluated using 1,1‑diphenyl‑2‑picrylhydrazyl radical‑scavenging activity. production 3‑deoxyglucosone (3‑DG) advanced glycation end products (AGEs) by reactions were determined high‑performance liquid chromatography fluorescence, respectively. Certain prevented AGE IC50 values compounds compared. These examined are assumed suppress...
A chemical examination of a root extract Oxytropis trichophysa led to the isolation and identification 23 compounds, including oxazole-type alkaloids isoflavonoid derivatives. Notably, three (1, 2, 3) two derivatives (7 10) were obtained from natural source for first time. In addition, O. derived 2,5-diphenyloxazoles their synthesized. Despite potential activity, antiplasmodial activities naturally occurring certain isoflavonoids remain unexplored. Therefore, both synthesized compounds...
Eleven 2,5-diphenyloxazole derivatives (1–11), together with six known isoflavonoid derivatives, were isolated from the roots of Oxytropis lanata. The (1) obtained proved to be identical a standard sample used as scintillator and liquid laser dye. other oxazole found have one four hydroxy and/or O-methyl groups in their phenyl rings. Seven are new (3–9). inhibitory activity compounds was evaluated against Trypanosoma congolense, causative agent African trypanosomosis animals. Oxazoles di-...
Eight new flavonoid-based 3′-O-β-d-glucopyranosides (1–8) and three galloyl glucosides (9, 11, 12), were isolated from the aerial parts of Saxifraga spinulosa, along with 25 known compounds. The structures compounds elucidated by spectroscopic methods. Most exhibited potent DPPH radical-scavenging activities. Further, their inhibitory activities evaluated against Babesia bovis, bigemina, caballi, Theileria equi, protozoan parasites that cause piroplasmosis in livestock. results indicated...
The Mongolian Artemisia adamsii (A. adamsii) plant is of particular interest from both medicinal and ecological perspectives. In this study, three previously undescribed sesquiterpenoids (1-3) were isolated, along with 25 known compounds, naturally dried browned aerial parts A. adamsii, which collected in the autumn pasturelands Bayan Soum, Tuv Province, Mongolia. chemical structures isolated including their relative absolute configurations, elucidated by high-resolution mass spectrometry,...
A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) comparison with reported spectral data. Nobiletin (IC50 of; 46.2 microM) exhibited more potency than Kojic acid (IC50; 77.4 used a positive control, it found to be potentially an effective production melanin.
Three Kampo medicines, Boiogito (BOT), Bofutsushosan (BTS) and Orengedokuto (OGT), used for obese patients were investigated their effects on adipogenesis in cultured rat white adipocytes. Administration of the three extracts suppressed concentration-dependent manners (1—100 μg/ml) without any cytotoxicity. Changes mRNA expression levels analyzed using a Rat 230 2.0 Affymetrix GeneChip® microarray system. DNA analysis (total probe set: 31099) cDNAs prepared from adipocytes revealed that BOT,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its S1 spike protein to bind angiotensin-converting enzyme (ACE2) on human cells in the first step of cell entry. Tryptanthrin, extracted from leaves indigo plant, Polygonum tinctorium, using d-limonene (17.3 µg/ml), is considered inhibit ACE2-mediated entry another type coronavirus, HCoV-NL63. The current study examined whether this extract could binding SARS-CoV-2 ACE2. Binding was quantified as cell-bound fluorescence...
Maintenance of pregnancy is highly dependent on the maternal immune system. High levels regulatory T cells (Tregs) accumulate in placenta to suppress immunoreactivity against fetal antigens. We assessed whether Astragalus root (AsR) and AsR-containing Kampo medicines modulate thereby increase mouse litter size. AsR-exposed murine splenocytes exhibited significantly increased IL-2 secretion. In mice, total Tregs were increased, whereas cytotoxic lymphocyte antigen 4 (CTLA-4)-positive...
Stress‑associated neuropsychiatric disease is associated with glucocorticoid levels; however, the behavior of mineralocorticoid receptors (MR) under conditions stress remain to be elucidated. Steroid in brain are classified into (GR) and/or MR, exhibiting a difference affinity for corticosteroids. The hippocampus one most stress‑susceptible regions brain. In present study, it was investigated whether two steroid affect hippocampal neuron damage. effect fludrocortisones (FD) on neurons caused...