A5065926491- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Multiple Sclerosis Research Studies
Harbin University of Commerce
2025
Guangxi Medical University
2025
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
First Affiliated Hospital of Zhengzhou University
2024
Tongji University
2011-2023
People's Hospital of Xinjiang Uygur Autonomous Region
2023
Shanghai Stomatological Hospital
2023
Ministry of Education of the People's Republic of China
2015-2022
National Clinical Research
2020-2022
To characterize the clinical features of IgG4-related disease (IgG4-RD) in China.A prospective cohort study IgG4-RD was carried out Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed were enrolled.A total 118 patients enrolled, including 82 males 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset lacrimal gland swelling (38/32.2%). A range organs involved: 77 (65.3%) had lymphadenopathy, 76 (64.4%) sialadenitis, 60 (50.8%)...
<h3>Objective:</h3> To study the longitudinal expression of interferon (IFN)-inducible genes in systemic lupus erythematosus (SLE) and determine their suitability as disease biomarkers. <h3>Methods:</h3> RNA was isolated from peripheral blood 94 patients with SLE 11 controls reverse transcribed into cDNA. The levels five IFN-responsive (<i>LY6E, OAS1, IFIT1, ISG15</i> <i>MX1</i>) were determined by quantitative PCR, normalised to <i>GAPDH</i> summed generate a global IFN score. Patients...
Background/Aims: MicroRNAs (miRNAs) play important roles in tumorigenesis. We investigated the and mechanisms of miR-138 human non-small cell lung cancer (NSCLC). Methods: The expression was first examined NSCLC lines tumourtissues by real-time PCR vitro vivo functional effect further. A luciferase reporter assay conducted to confirm target association between enhancer zeste homolog 2 (EZH2). Results: frequently downregulated cells tissues. Overexpression inhibited proliferation tumor growth...
Background: Myocarditis is an uncommon but serious manifestation of systemic lupus erythematosus (SLE). This study aimed to investigate clinical characteristics and outcomes myocarditis (LM) determine risk factors LM in hospitalized Chinese patients with SLE. Methods: We conducted a retrospective case–control study. A total 25 from 2001 2012 were enrolled as the group, 100 SLE without randomly pooled control group. Univariable analysis was performed using Chi-square tests for categorical...
Temporomandibular joint osteoarthritis (TMJOA) is a common inflammatory disease that can cause pain, cartilage degradation, and subchondral bone loss. However, the key regulatory factors new targets for treatment of TMJOA have yet to be determined. Long noncoding RNAs (lncRNAs) shown remarkable potential in regulating tissue homeostasis development. The long intergenic RNA-erythroid prosurvival (lincRNA-EPS) reported an effective inhibitor inflammation, but its role unexplored. Here, we...
Objective This study aimed to identify the clinical characteristics and prognostic factors of systemic lupus erythematosus with transverse myelitis (SLE-TM) in a relatively large patient series. Methods retrospective considered 45 SLE-TM individuals treated as inpatients outpatients at Peking Union Medical College Hospital between 1993 2018. patients were compared 180 controls, neuromyelitis optica spectrum disorder (NMOSD) those without NMOSD. Results Compared group frequently had fever...
Abstract The aim of this study was to explore the feasibility Raman spectroscopy combined with computer algorithms in diagnosis primary Sjögren syndrome (pSS). In study, spectra 60 serum samples were acquired from 30 patients pSS and healthy controls (HCs). means standard deviations raw HCs calculated. Spectral features assigned based on literature. Principal component analysis (PCA) used extract spectral features. Then, a particle swarm optimization (PSO)-support vector machine (SVM)...
Objective Myocardial infarction (MI) is a leading cause of death worldwide, accounting for millions fatalities annually. The injury and repair cardiomyocytes are closely associated with the changes in gene expression. MicroRNAs could serve as potential target MI treatment. This work aims to investigate role miR-3148 mitochondrial dynamics during acute (AMI) specific focus on its regulatory mechanisms mitophagy apoptosis, which reveal therapeutic targets AMI Material Methods MiR-3148 levels...
The hypoxia/reoxygenation (H/R)-induced pyroptosis of cardiomyocytes plays a crucial role in the pathogenesis myocardial infarction (MI). miR-155-5p represents promising target for MI therapy. However, its involvement H/R-induced remains unclear. H/R exposed rat cardiomyocyte H9c2 was utilized as vitro model, and expression levels SIRT1 cells were modulated through cell transfection experiments. Cell proliferative activity assessed using counting kit-8 assay. Supernatant lactate...
The aim of this study was to evaluate the efficacy and safety biosimilar candidate adalimumab (HS016) compared with (Humira) for treatment active ankylosing spondylitis. A multicenter, randomized, double-blind, parallel, positive control, phase III clinical trial conducted at 28 locations in China. Patients spondylitis were randomized a 2:1 ratio subcutaneously receive 40 mg either HS016 or every other week 24 weeks. primary endpoint achieve least 20% improvement (ASAS20) patients weeks...
Objective: The aim of our study was to assess the influence HLA-B27 status on axial spondyloarthritis (axSpA) in largest cohort China. Methods: An observational, cross-sectional, and analytic axSpA patients from China database performed. Demographic clinical data were compared terms status. Univariate multivariate analyses performed identify variables related presence. Results: We enrolled 4,131 this study; those, 36,95 (89.4%) positive. In analysis, male gender ( p &lt; 0.001), younger...
Introduction Many studies have shown that differences were observed between male and female lupus patients. Although systemic erythematosus (SLE) affects mostly females (female:male ratio 9:1), SLE patients show higher mortality due to kidney neurological disease. Currently there are limited epidemiological data concerning in the Chinese population. As such, Treatment Research group (CSTAR) developed first online registry of 2009, represents a multicenter observational study attempts...
Systemic lupus erythematosus (SLE) has protean clinical manifestations of varying severity over the course its onset, exacerbation, remission and flare that could often pose significant challenges for clinicians in their decision making as to whether treat aggressively or look concurrent conditions such infection with opportunistic pathogens. Human cytomegalovirus (HCMV) is one those pathogens frequently encountered our daily management patients. To investigate characteristics therapeutic...
Objective As primary Sj?gren's syndrome (pSS) primarily affects the salivary glands, saliva can serve as an indicator of glands' pathophysiology and disease's status. This study aims to illustrate proteomic profiles pSS patients identify potential candidate biomarkers for diagnosis.Methods The discovery set contained 49 samples (24 from 25 age- gender-matched healthy controls [HCs]) validation included (12 13 HCs). Totally 36 38 HCs were centrally randomized into or at a 2:1 ratio....
Objective To identify long-term fasting blood glucose trajectories and to assess the association between risk of arterial stiffness in individuals without diabetes. Methods We enrolled 16,454 non-diabetic participants from Kailuan cohort. Fasting concentrations were measured 2006, 2008, 2010 survey. Brachial-ankle pulse wave velocities during 2011 2016. Multivariate regression model was used estimate difference brachial-ankle velocity levels logistic calculate odds ratios (ORs) 95%...