A5100628194- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Pleural and Pulmonary Diseases
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Acupuncture Treatment Research Studies
- Systemic Lupus Erythematosus Research
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal motility and disorders
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Cancer Immunotherapy and Biomarkers
Chengdu University of Traditional Chinese Medicine
2024-2025
Union Hospital
2013-2024
Huazhong University of Science and Technology
2013-2024
Union Hospital
2010-2024
Shandong Provincial QianFoShan Hospital
2023-2024
Shandong First Medical University
2023-2024
Huanggang Central Hospital
2021-2024
Anhui University
2024
First Affiliated Hospital of GuangXi Medical University
2012-2023
Guangxi Medical University
2012-2023
Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. In this study, we examined the relationship between fasting blood glucose (FBG) 28-day coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes.We conducted a retrospective study involving all consecutive COVID-19 definitive outcome FBG measurement at admission from 24 January 2020 to...
This study investigated the application of a therapeutic tumor cell–derived microparticle-based nanodelivery platform in malignant pleural effusion.
Alzheimer's disease (AD) is a growing concern in the modern society. The current drugs approved by FDA are not very promising. Rhynchophylline (RIN) major active tetracyclic oxindole alkaloid stem from traditional Chinese medicine uncaria species, which has potential activities beneficial for treatment of AD. However, application rhynchophylline AD restricted low water solubility, concentration brain tissue and bioavailability. And there no study brain-targeting therapy with RIN. In this...
Abstract Background Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors 14-day and 28-day mortality develop model for predicting survival probability among adult hospitalized patients with COVID-19. Methods In this multicenter, retrospective, cohort study, we examined 828 confirmed COVID-19 in Wuhan Union Hospital Central between January 12 February 9, 2020. Among patients, 516 186 consecutive admitted were enrolled...
Ocular and childhood myasthenia gravis (MG) cases seem relatively more common in Oriental than Caucasian populations, but there have been no comprehensive serological studies on patients from mainland China.391 unselected with MG attending Tongji Hospital WuHan (the largest hospital the province of HuBei, China) were studied during a 15-month period; most had already received treatment for their condition.The male to female ratio was 0.8. 50% children (<15 years), age at onset showed single...
Epidermal growth factor receptor (EGFR) mutations and the anaplastic lymphoma kinase (ALK) rearrangement are two most common druggable targets in non-small cell lung cancer (NSCLC). However, genetic testing is sometimes unavailable. Previous studies regarding predictive role of 18F–FDG PET/CT for EGFR NSCLC patients conflicting. We investigated whether or not PET could be a valuable noninvasive method to predict ALK positivity using largest patient cohort date. retrospectively reviewed...
Purpose: Smoking is a strong relative risk factor for lung cancer. Extracellular vesicles (EVs), particularly exosomes, have been implicated in cancers. In this study, we characterized smoking induced extracellular smokers with non-small cell cancer (NSCLC). Methods: EVs were isolated from bronchoalveolar lavage (BAL) and NSCLC patients. EV microRNAs (miRNAs) analyzed by using TaqMan microRNA assays. Vesicle mRNAs long non-coding RNAs (lncRNAs) measured quantitative RT-PCR. Tumor associated...
ABSTRACT Pleural effusion is a common respiratory disease worldwide; however, rapid and accurate diagnoses of tuberculosis pleural (TPE) malignancy (MPE) remain challenging. Although extracellular vesicles (EVs) have been confirmed as promising sources biomarkers, little known about the metabolite compositions its subpopulations their roles in diagnosis effusion. Here, we performed metabolomics lipidomics analysis to investigate characteristics two EV derived from by differential...
Elucidation of the molecular mechanisms involved in pathogenesis coronavirus disease 2019 (COVID-19) may help to discover therapeutic targets.To determine metabolomic profile circulating plasma from COVID-19 survivors with pulmonary sequelae 3 months after discharge, a random, outcome-stratified case-control sample was analyzed. We enrolled 103 recovered patients as well 27 healthy donors, and performed function tests, computerized tomography (CT) scans, laboratory examinations, liquid...
Abstract More and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, their molecular changes especially proteome also play same important role in understanding biological as do. In our study, we reported whole lung-ground glass-CT value-average mild/severe 3 months after discharge without underlying diseases was significantly lower...
Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous tumor with substantial somatic mutations and genome instability, which are emerging hallmarks of cancer. Long non-coding RNAs (lncRNAs) promising cancer biomarkers that reportedly involved in genomic instability. However, the identification instability-related lncRNAs (GInLncRNAs) their clinical significance has not been investigated LUAD. Methods: We determined GInLncRNAs by combining mutation transcriptome data 457 patients...
Abstract Background Postdischarge immunity and its correlation with clinical features among patients recovered from coronavirus disease 2019(COVID-19) are poorly described. This prospective cross-sectional study explored the inflammatory profiles recovery of COVID-19 at 3 months after hospital discharge. Methods Patients discharged 4 hospitals in Wuhan, asymptomatic (APs) an isolation hotel, uninfected healthy controls (HCs) were recruited. Viral nucleic acid antibody detection, laboratory...
Abstract Background Malignant tumours seriously threaten human life and health, effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturbance inhibit tumour growth has been increasingly studied, but its dynamic role in the corresponding effects leading mitotic catastrophe DNA damage have rarely studied. Results In this paper, we found that nucleoprotein SHCBP1 exhibits spatiotemporal expression during...