A5100669622- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Service-Oriented Architecture and Web Services
- Complex Network Analysis Techniques
- Intraocular Surgery and Lenses
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Corneal surgery and disorders
- Head and Neck Cancer Studies
- Caching and Content Delivery
- Advanced Computing and Algorithms
- Digital Rights Management and Security
- Innovative Education and Learning Practices
- Peptidase Inhibition and Analysis
- Lightning and Electromagnetic Phenomena
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Acupuncture Treatment Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Autoimmune and Inflammatory Disorders Research
- Ultrasound in Clinical Applications
Tongji Hospital
2018-2025
Huazhong University of Science and Technology
2013-2025
Sun Yat-sen University
2021-2025
Children's Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
National Clinical Research
2024
Peking Union Medical College Hospital
2008-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2023
Renmin University of China
2007-2022
China Medical University
2014-2019
Objective Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID‐19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role COVID‐19 remains unclear. This study was undertaken determine prevalence and aPLs COVID‐19. Methods Sera collected from 66 who were 13 not tested by chemiluminescence immunoassay for anticardiolipin (aCLs), anti–β 2 ‐glycoprotein I (anti‐β GPI) (IgG, IgM, IgA), IgG anti‐β GPI–domain...
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that circulating cell population expressing CD19+CD24-CD38hi was increased in patients with IgG4-RD. In this study, we aimed to document represented plasmablasts/plasma cells, identify the detailed phenotype and gene expression profile of these IgG4-secreting determine whether B-cell lineage subset could be biomarker IgG4-related (IgG4-RD).A total 42 untreated IgG4-RD were...
Abstract Aim to evaluate the efficacy and safety of glucocorticoid monotherapy vs combination therapy cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD). 102 newly diagnosed IgG4-RD patients were enrolled assigned 2 groups: Group I was prednisone (0.5–1.0 mg/kg.d, tapered gradually) II CYC (50–100 mg per day). Patients assessed at different periods. Primary end point relapse rate; secondary points included response, remission rate adverse effects. 52 in 50 II. At 1 month, both groups...
Objective To determine the number and function of follicular helper T (Tfh) cell subsets in IgG4‐related disease (IgG4‐ RD ). Methods Mononuclear cells from peripheral blood involved tissue patients with IgG4‐ were assessed for Tfh their subsets, levels B lymphoma 6 (Bcl‐6), lymphocyte–induced maturation protein 1 ( BLIMP ‐1), interleukin‐21 IL ‐21) messenger RNA mRNA Immunohistochemical immunofluorescence techniques used to assess location ‐21, Bcl‐6, CD 4+ CXCR 5+ cells. Furthermore,...
To investigate clinical and radiological features of IgG4-related disease (IgG4-RD) patients with intrathoracic involvement. A prospective cohort study was performed IgG4-RD were enrolled from January 2011 to March 2015 in Peking Union Medical College Hospital, which the characteristics involvement summarized. Out total 248 cases IgG4-RD, 87 had lesions, including 58 male 29 female cases, average age 54.19 ± 13.80 years. Hilar mediastinal lymphadenopathy most common manifestations disease,...
Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic that can involve multiple organs and various clinical phenotypes. The purpose of this study was to analyze different types organ involvement in IgG4-RD patients China.We conducted prospective cohort on the manifestations rare features IgG4-RD. Patients were grouped into according regarding number site. constituent ratio also analyzed.A total 200 patients, with male:female 2.08:1, types. Cases having two or three most...
In order to evaluate the efficacy and safety of high versus medium doses glucocorticoid therapy in remission induction immunoglobulin G4-related disease (IgG4-RD), we set up a randomized controlled study.Newly diagnosed IgG4-RD patients were randomly assigned two groups: prednisone (0.8-1.0 mg/kg/day) (0.5-0.6 mg/kg/day). Patients assessed at weeks 0, 4, 12 24. The primary outcome was rate week secondary endpoints included responder index (IgG4-RD RI), IgG IgG4 levels.Twenty cases each group...
Abstract Background: Pulmonary embolism (PE) is a severe and acute cardiovascular syndrome with high mortality among patients autoimmune inflammatory rheumatic diseases (AIIRDs). Accurate prediction timely intervention play pivotal role in enhancing survival rates. However, there notable scarcity of practical early risk assessment systems PE AIIRD. Methods: In the training cohort, 60 AIIRD cases 180 age-, gender-, disease-matched non-PE were identified from 7254 Tongji Hospital 2014 to 2022....
The aim of this study is to investigate the incidence and pattern traumatic fractures (TFs) as a result falls in population children adolescents (≤18 years old) China.This was cross-sectional study. We retrospectively reviewed 1412 patients who were with TFs admitted our university-affiliated hospitals China from 2001 2010. Etiologies included high fall (height ≥2) low <2 m). summarized respect different age groups, year admission, etiologies, genders, neurological function.This enrolled...
To investigate the effects of thalidomide in preventing disease relapse with 'zero' glucocorticoids (GCs) usage IgG4-related (IgG4-RD). This was a multicentre, randomised, double-blinded, placebo-controlled study, which eligible patients active status were randomised into 2 groups (group 1: GCs+Thalidomide; group 2: GCs+Placebo) at 1:1 ratio. The primary outcome this trial rate month 12, whereas secondary outcomes remission 12 and incidence adverse events (AEs). A total 60 57...
Précis: 240° and 360° goniotomy (GT) demonstrated similar efficacy in intraocular pressure reduction, both outperforming 120°GT juvenile open-angle glaucoma (JOAG) patients at postoperative 6 months follow-up. Purpose: To compare the surgical safety of 120-, 240-, 360-degree for with (JOAG). Patients Methods: This multicenter retrospective study included 102 eyes JOAG patients, who underwent GT a follow up least months. were categorized into three groups: (1) 120°GT, (2) 240°GT, (3) 360°GT....
Resources in cloud computing platforms such as Amazon, Google AppEngine, and Microsoft Azure are a natural fit to remedy the lack of local resources mobile devices, which creates new space search improve availability resources. In essence, is context-aware personalized activity since devices' inherent movability allows people retrieve information anytime anywhere. However, current products always far from accuracy centered on convergence platforms. this paper, hybrid filtering mechanism...
Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized chronic fibro-inflammatory autoimmune disease, and its recognition has been constantly increasing worldwide over the last few years. A correct timely recognition, as well appropriate intervention, crucial for treatment of IgG4-RD. For certain subtypes IgG4-RD, organ-specific criteria are formulated to make diagnosis more accurate. New biomarkers have emerged in recent years aid diagnosis, prognosis prediction, therapy response...
Aims To characterise the influence of primary open-angle glaucoma (POAG) and high myopia (HM) on macular choroidal capillary density (CD). Methods Two hundred seven eyes were enrolled, including 80 POAG without HM, 50 with 31 HM 46 normal controls. A fovea-centred 6×6 mm optical coherence tomography angiography scan was performed to obtain CD superficial plexus (SCP), deep (DCP) choriocapillaris. Macular CDs compared among groups association visual field mean deviation (MD) determined using...
Objective: To analyze the feature of breast complex cystic masses and to classify it at ultrasonography (US), which applied Breast Imaging Reporting Data System (BI-RADS) categories 4a 4c with pathological results as golden standards. Methods: The ultrasonographic data clinical features 78 patients confirmed by pathology in Cancer Hospital from July 2014 June 2017 were retrospectively reviewed. divided into four classes on basis their US features: type 1 [thick wall (or) thick septa (> 0.5...
Deep reinforcement learning (deep RL) has enabled human- or superhuman- performances in various applications. Recently, deep RL also been adopted to improve the performance of quantum control. However, a large volume data is typically required train neural network RL, making it inefficient compared with traditional optimal control method. Here, we thus develop new training algorithm inspired by meta-reinforcement meta-RL), which requires significantly less data. The trained adaptive and...
In this study, we aimed to assess the value of therapeutic plasma exchange (TPE) in treatment rheumatic diseases and compare safety different replacement fluids used TPE.A total 727 TPE procedures 285 patients (57 males, 228 females; mean age: 39.7±15.4 years; range, 13 79 years) with between January 2011 February 2019 were retrospectively analyzed. Data including demographic clinical characteristics recorded. Treatment response adverse events evaluated all patients.Indications for included...