A5025821411- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Medical Image Segmentation Techniques
- AI in cancer detection
- Image Retrieval and Classification Techniques
- Energy Efficient Wireless Sensor Networks
- Indoor and Outdoor Localization Technologies
- Fault Detection and Control Systems
- Ocular Surface and Contact Lens
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Retinopathy of Prematurity Studies
- Ocular Infections and Treatments
- Cancer-related molecular mechanisms research
- Ophthalmology and Visual Impairment Studies
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Medical Imaging and Analysis
- Folate and B Vitamins Research
- Optical Imaging and Spectroscopy Techniques
- Neurological Complications and Syndromes
Sun Yat-sen University
2020-2025
State Key Laboratory of Ophthalmology
2024
Zhongshan Hospital
2023
Zhongshan Ophthalmic Center, Sun Yat-sen University
2021-2023
Hong Kong Polytechnic University
2023
The Royal Victorian Eye & Ear Hospital
2023
Fujian Medical University
2018-2020
First Affiliated Hospital of Fujian Medical University
2018-2020
Fujian Institute of Microbiology
2019
Beijing University of Posts and Telecommunications
2014-2015
By 2040, ~100 million people will have glaucoma. To date, there are a lack of high-efficiency glaucoma diagnostic tools based on visual fields (VFs). Herein, we develop and evaluate the performance 'iGlaucoma', smartphone application-based deep learning system (DLS) in detecting glaucomatous VF changes. A total 1,614,808 data points 10,784 VFs (5542 patients) from seven centers China were included this study, divided over two phases. In Phase I, 1,581,060 10,135 5105 patients to train (8424...
Purpose: To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics primary open-angle glaucoma (POAG) eyes with and without high myopia. Methods: In total, 63 61 POAG myopia, respectively, underwent swept-source OCTA imaging at least four follow-up visits an ophthalmic center, a scanning protocol of 3- × 3-mm centered the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, vessel density (VD) both...
To evaluate the ocular and systemic determinants of choriocapillaris flow deficits percentage (CC FD%) in normal eyes.Observational cross-sectional study.Healthy Chinese participants without or diseases underwent detailed ophthalmic evaluations, including swept-source optical coherence tomography angiography (SS-OCTA) with 6- × 6-mm macular images. The CC FD% was assessed circular regions diameters 1.0 5.0 mm, rings 1.0- to 2.5-mm diameters, 2.5- 5.0-mm diameters.The study included 830...
Purpose: The purpose of this study was to determine the longitudinal changes in macular retinal and choroidal microvasculature normal healthy highly myopic eyes. Methods: Seventy-one eyes, including 32 eyes with high myopia 39 control followed for at least 12 months examined using optical coherence tomography angiography imaging 3 visits, were included study. Fovea-centered 6 × mm scans performed measure capillary density (CD) superficial plexus (SCP), deep (DCP), choriocapillaris (CC)....
Background To investigate whether quantitative optical coherence tomography angiography (OCTA) metrics of the superficial/deep macular retina and optic disc are associated with glaucoma progression risk. Methods A total 238 eyes from 119 patients open angle or ocular hypertension, no history systemic hypertension diabetes mellitus were included. All participants underwent OCTA imaging a swept-source OCT (DRI-OCT 1, Topcon, Japan). superficial capillary plexus (SCP) deep (DCP) in region,...
To investigate the association between choriocapillaris flow deficit percentage (CC FD%) and 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM).This prospective cohort study included DM. The DR status was graded based on ETDRS-7 photography. CC FD% central 1 mm area, inner circle (1.5 to 2.5 mm), outer (2.5 5.0 mm) entire area macular region were measured using swept-source optical coherence tomography angiography (SS-OCTA). Logistic...
To evaluate the association between green space exposure and dry eye. Part I: case-control study. II: cross-sectional The study contained 450 patients with eye 900 controls recruited from Electronic Health Records. Logistic regression analysis was employed to investigate relationship occurrence of This included 140 diabetic participants community registry in Guangzhou, China. Linear used assess quantitative measures tear meniscus. A total 1,350 individuals were On average aged 31.07 ± 4.58...
In wireless sensor network, data loss is inevitable due to its inherent characteristics. This phenomenon even serious in some situation which brings a big challenge the applications of data. However, traditional estimation methods can not be directly used network and existing algorithms fail provide satisfactory accuracy or have high complexity. To address this problem, Temporal Spatial Correlation Algorithm (TSCA) proposed estimate missing as accurately possible paper. Firstly, it saves all...
Abstract Background To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy. Methods Neonatal C57BL/6 mice were exposed in hyperoxygen returned room air develop oxygen-induced retinopathy (OIR). Red fluorescent protein-labeled BMSC Conbercept intravitreally injected into OIR mice, respectively. Inhibition apoptosis assessed through angiography,...
Purpose: To evaluate the frequency of and identify factors that influence artifacts swept-source optical coherence tomography angiography (SS-OCTA) in glaucomatous normal eyes. Methods: Artifacts OCTA images open-angle glaucoma (OAG) subjects were analyzed using SS-OCTA. Univariate multivariate logistic regression analyses performed to association age, sex, best-corrected visual acuity, axial length (AL), intraocular pressure, presence severity OAG, image quality score (IQS) with artifacts....
Purpose: To identify the ocular factors of microvascular fractal dimension (FD) and blood vessel tortuosity (BVT) macula measured with optical coherence tomography angiography (OCTA) in a healthy Chinese population. Methods: Healthy subjects without disorders were recruited at Zhongshan Ophthalmic Center. The FD BVT superficial capillary plexus (SCP) deep (DCP) obtained from OCTA images. was calculated using box-counting method, defined as ratio actual distance between two points to straight...
The purpose of this study was to investigate whether the rapid rate peripapillary retinal nerve fiber layer (pRNFL) thinning in short-term is associated with future risk developing diabetic retinopathy (DR).
Optical Coherence Tomography Angiography (OCTA) is a non-invasive and non-contacting imaging technique providing visualization of microvasculature retina optic nerve head in human eyes vivo. The adequate image quality OCTA the prerequisite for subsequent quantification retinal microvasculature. Traditionally, score based on signal strength used discriminating low quality. However, it insufficient identifying artefacts such as motion off-centration, which rely specialized knowledge need...
Aims To characterise the influence of primary open-angle glaucoma (POAG) and high myopia (HM) on macular choroidal capillary density (CD). Methods Two hundred seven eyes were enrolled, including 80 POAG without HM, 50 with 31 HM 46 normal controls. A fovea-centred 6×6 mm optical coherence tomography angiography scan was performed to obtain CD superficial plexus (SCP), deep (DCP) choriocapillaris. Macular CDs compared among groups association visual field mean deviation (MD) determined using...
Purpose The purpose is to investigate the association between handgrip strength (HGS) and risk of future diabetic complications in multicountry cohorts. Methods HGS was evaluated using cox models among 84 453 patients with pre-diabetes diabetes from UK Biobank a 12-year follow-up. longitudinal microcirculatory damage rates assessed 819 Guangzhou Diabetic Eye Study (GDES) 3-year Participants were divided into three age groups (<56, 56–65 ≥65 years), each group further subdivided tertiles....
To evaluate the longitudinal rate of choriocapillaris flow deficits (CFD) in healthy participants and patients with diabetes mellitus.
This study aimed to characterise imaging artefacts in the lacrimal gland using swept-source optical coherence tomography (SS-OCT) patients with dry eye disease (DED) and healthy participants identify risk factors for these artefacts.
Myopic maculopathy and glaucoma belong to the most common causes of irreversible blindness worldwide and, having an ocular axial elongation as one their main risk factors, can occur together. The detection glaucomatous optic neuropathy (GON) in highly myopic eyes is clinically technically difficult, there no information available, neither about natural course GON or under intraocular pressure-lowering therapy. We therefore designed this study explore eyes.In single-centred longitudinal...