A5100425062- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Electrohydrodynamics and Fluid Dynamics
- Plasma Diagnostics and Applications
- Parkinson's Disease Mechanisms and Treatments
- Ocular Surface and Contact Lens
- Optical Coherence Tomography Applications
- Effects of Radiation Exposure
- Plasma Applications and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Topic Modeling
- Drug-Induced Hepatotoxicity and Protection
- Intraocular Surgery and Lenses
- Dermatologic Treatments and Research
- Nephrotoxicity and Medicinal Plants
- Genetic Neurodegenerative Diseases
- Ophthalmology and Visual Impairment Studies
- Mitochondrial Function and Pathology
- Pharmacological Effects of Natural Compounds
- Amyotrophic Lateral Sclerosis Research
- Microwave Engineering and Waveguides
- Cellular Mechanics and Interactions
Jilin University of Finance and Economics
2025
Nanchang University
2013-2024
Third Affiliated Hospital of Nanchang University
2013-2024
Army Medical University
2023
Third Hospital of Nanchang
2017-2022
Guangzhou Medical University
2020
University of California, San Francisco
2013-2014
Emory University
2008-2010
Motor axon degeneration is a critical but poorly understood event leading to weakness and muscle atrophy in motor neuron diseases. Here, we investigated oxidative stress-mediated axonal mice lacking the antioxidant enzyme, Cu,Zn superoxide dismutase (SOD1). We demonstrate progressive axonopathy these show that Sod1−/− primary neurons extend short axons vitro with reduced mitochondrial density. also oxidation of mitochondrial—but not cytosolic—thioredoxin, suggesting loss SOD1 causes...
By 2040, ~100 million people will have glaucoma. To date, there are a lack of high-efficiency glaucoma diagnostic tools based on visual fields (VFs). Herein, we develop and evaluate the performance 'iGlaucoma', smartphone application-based deep learning system (DLS) in detecting glaucomatous VF changes. A total 1,614,808 data points 10,784 VFs (5542 patients) from seven centers China were included this study, divided over two phases. In Phase I, 1,581,060 10,135 5105 patients to train (8424...
To determine if factors associated with gonioscopy-determined occludable angle among American Caucasians are similar to those found in ethnic Chinese.This is a prospective cross-sectional study 120 Caucasian, 116 Chinese, and mainland Chinese subjects. All three groups were matched for sex age (40-80 years). Gonioscopy was performed each subject (occludable angles = posterior trabecular meshwork not visible ≥2 quadrants). Anterior segment optical coherence tomography customized software used...
Purpose: Validation of the feasibility novel acoustic radiation force optical coherence elastography (ARF-OCE) for evaluation biomechanical enhancement in vivo model keratoconus by clinical cross-linking (CXL) surgery. Methods: Twelve rabbit corneas were randomly divided into two groups. Both groups treated with collagenase type II, and a was obtained. Then, CXL procedures different irradiation energy 15 J 30 (CXL-15 CXL-30 J, respectively). An ARF-OCE probe an ultrasmall ultrasound...
Objectives This prospective study aims to evaluate the outcomes and safety of Ultrasound Cycloplasty(UCP) in controlling intraocular pressure patients with prior failed glaucoma surgeries. Methods A total 20 eyes from 19 who underwent UCP following surgery between September 2020 2022, were included. All followed for over 12 months. Intraocular pressure, ocular hypotensive medications, best-corrected visual acuity recorded compared after surgery. Complete success was defined as within range...
The rapid growth of information technology has led to an explosion data, posing a significant challenge for data processing. Recommendation systems aim address this by providing personalized content recommendations users from vast datasets. Recently, multimodal recommendation have gained considerable attention due their ability leverage diverse modalities (e.g., images and text) more accurate recommendations. However, effectively fusing these accurately represent user preferences remains...
The aim of this study was to investigate the genetic basis and pathogenic mechanism variable maculopathies, ranging from mild photoreceptor degeneration central areolar choroidal dystrophy, in a five-generation family.Clinical characterizations, whole-exome sequencing, genome-wide linkage analysis were carried out on family. Zebrafish models used pathogenesis GUCA1A mutations.A novel mutation, p.R120L, identified family predicted alter tertiary structure guanylyl cyclase-activating protein...
To evaluate peripapillary atrophy (PPA) in high myopia (HM) as a function of extent myopia, axial length (AL), and age.Medical records from patients (n = 88) seen the Ophthalmology Department Third Affiliated Hospital Nanchang University, Nanchang, Jiangxi, China, diagnosed with (HM)-defined spherical equivalent (SE) >6.00 diopters (D) either eye-were included this study. Eyes were classified according to SE age. For classification, individual eyes 169) arranged follows: groups A1 (SE...
<h3>Background</h3> To investigate the prevalence, risk factors and characteristics of plateau iris configuration (PIC) among American Caucasian, Chinese mainland Chinese. <h3>Methods</h3> This multicentre, cross-sectional study non-glaucomatous subjects (40–80 years) included 111 116 110 Prevalence PIC based on ultrasound biomicroscopy imaging was compared different ethnic groups. Risk anterior segment optical coherence tomography-measured angle parameters in eyes with were compared....
Purpose: Quantification of biomechanical properties keratoconus (KC) corneas has great significance for early diagnosis and treatment KC, but the corresponding clinical measurement remains challenging. Here, we developed an acoustic radiation force (ARF) optical coherence elastography technique explored its potential evaluating KC corneas. Methods: An ARF system was used to induce tissue deformation, which detected by tomography system, thus localized point-by-point Young's modulus...
The purpose of this study is to quantitatively evaluate the differences in corneal biomechanics after SMILE and FLEx surgery using an acoustic radiation force optical coherence elastography system (ARF-OCE) analyze effect cap on integrity biomechanical properties. A custom ring array ultrasound transducer used excite tissue produce Lamb waves. Depth-resolved elastic modulus images vivo cornea refractive were obtained based phase velocity wave. After surgery, average flap decreased (71.7 ±...
High Intensity Macro and Micro Focused Ultrasound ( HIFU) is a safe effective method for the treatment of skin laxity. However, application high-intensity focused ultrasound energy on eyelids has been associated with potential ocular complications including traumatic cataract, iridocyclitis, conjunctival hemorrhage, among others. A 40-year-old female developed blurred vision in her left eye after receiving HIFU binocular eyelids, far was 20/66. The examination revealed iris depigmentation...
Purpose. Corneal endothelial cells are usually exposed to shear stress caused by the aqueous humour, which is similar exposure of vascular blood flow. However, effect fluid on corneal still poorly understood. The purpose this study was explore whether that results from humour influences cells. Methods. An in vitro model established generate flow cells, and after two levels for different durations investigated. mRNA protein expression endothelium-related markers rabbit evaluated real-time PCR...
The scleral elasticity is closely related with many ocular diseases, but the relevant research still insufficient. Here, we utilized optical coherence elastography to carefully study biomechanical properties of sclera at different positions and under intraocular pressures. Meanwhile, elastic wave velocity Young's modulus each position were obtained using a phase algorithm. Accordingly, two-dimensional distribution image was achieved by mapping values corresponding structure based on...
What is known and objective The blood concentration of tacrolimus can be affected by co-administrated drugs. to draw more attention herb-drug interactions in China, where herbal medicines are commonly used. Case description a girl with refractory nephrotic syndrome decreased nearly half despite no change dose. Nebulizer therapy, cyclophosphamide compound Chinese medicine were the only additional treatments than usual. new conclusion most possible cause decrease was administration Radix...
Several familial forms of Parkinson disease are linked to mutations in α‐synuclein (α‐syn), a major component Lewy bodies. One proposed role for α‐syn dopaminergic neurons is the maintenance dopamine (DA) homeostasis. We have identified an interaction with and vesicular monoamine transporter 2 (VMAT2). VMAT2 sequesters cytosolic DA into vesicles release at synaptic terminals. Here, we show between C‐terminus by yeast two‐hybrid assay. This confirmed coimmunoprecipitation SHSY5Y cells....
Intestinal mucositis is the major side effect during abdominal or pelvic radiotherapy, but underlying immunogen remains to be further characterised and few radioprotective agents are available. This study investigated role of dsDNA-triggered inflammasomes in intestinal radiotherapy.Pro-inflammatory cytokines were detected by ELISA. Radiation-induced injury mice was analyzed means survival curves, body weight, HE staining intestines, barrier integrity. Western blot, immunofluorescence...
<title>Abstract</title> Objectives To explore effects of ultrasound cycloplasty (UCP) in glaucoma patients, aiming to evaluate the efficacy and safety UCP. Methods Twenty-two patients (23 eyes) who received UCP treatment at Ophthalmology Department Nanchang First Hospital from July 2020 September 2022 were selected.Intraocular pressure (IOP), number anti-glaucoma agents, best corrected visual acuity (BCVA) eye pain scores before 1, 3, 7 days, 3 6 months after recorded.The complications...
Abstract Patients with advanced prostate cancer inevitably acquire resistance to anti-androgen therapies, and progress lethal castration-resistant (CRPC). The mechanisms involve AR gene amplification overexpression, constitutively active ligand-independent splice variants such as AR-V7, the mutations in ligand-binding domain (LBD). Our previous study has shown that N-terminal (NTD) is responsible for liquid-liquid phase separation (LLPS) capability, which essential AR/AR-V7 transcriptional...
You have accessJournal of UrologySurgical Technology & Simulation: Artificial Intelligence II (PD27)1 May 2024PD27-07 ENHANCING PRECISION AND EFFICIENCY: DEEP LEARNING IN BLADDER TUMOR DETECTION Zixing Ye, Yingjie Li, Zhigang Ji, Jianyang Lv, Hongbo Zhang, Yujiao Sun, and Chengqing He YeZixing Ye , LiYingjie Li JiZhigang Ji LvJianyang Lv ZhangHongbo Zhang SunYujiao Sun HeChengqing View All Author Informationhttps://doi.org/10.1097/01.JU.0001008580.58088.27.07AboutPDF ToolsAdd to...
Photorefractive intrastromal corneal cross-linking (PiXL) treatment corrects myopia by enhancing localized central biomechanics. However, the dose-effect relationship between changes in biomechanics and alterations curvature resulting from this remain unclear. We therefore developed an acoustic radiation force optical coherence elastography (ARF-OCE) technique to investigate PiXL.