A5101858352- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ocular Oncology and Treatments
- COVID-19 and Mental Health
- Ubiquitin and proteasome pathways
- Global Maternal and Child Health
- Protein Degradation and Inhibitors
- Protein Tyrosine Phosphatases
- Virus-based gene therapy research
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Healthcare Systems and Reforms
- Glaucoma and retinal disorders
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Multiple Myeloma Research and Treatments
Third Affiliated Hospital of Nanchang University
2017-2024
Nanchang University
2015-2024
Third Hospital of Nanchang
2017-2024
Sun Yat-sen University
2012-2024
Wuhan University of Science and Technology
2021
Huazhong University of Science and Technology
2021
Wuhan No.1 Hospital
2008-2009
Wuhan Third Hospital
2008
Background: University students who are exposed to coronavirus disease 2019 (COVID-19) could be mentally distressed. We aimed evaluate the pattern and risk factors of mental health suicidal behavior among experienced long-term school closure due COVID-19 pandemic. Methods: This large-sample, cross-sectional, online survey was conducted from June 29, 2020, July 18, 2020. Eleven thousand two hundred fifty four participants were recruited 30 universities located in Wuhan, Hubei Province, China....
Abstract Chemotherapy resistance is the major cause of nasopharyngeal carcinoma (NPC) treatment failure. Tripartite motif-containing protein (TRIM) family members play important roles in tumor development and chemotherapy Here, based on a screening analysis 71 TRIM by qRT-PCR, we first confirmed that TRIM11 levels were significantly higher drug-resistant NPC cells than non-drug-resistant cells, high expression predicted poor overall survival (OS) progression-free (PFS). N(6)-Methyladenosine...
Abstract Histone deacetylases (HDACs) are involved in tumor progression, and some have been successfully targeted for cancer therapy. The expression of histone deacetylase 4 (HDAC4), a class IIa HDAC, was upregulated our previous microarray screen. However, the role HDAC4 dysregulation mechanisms underlying growth metastasis nasopharyngeal carcinoma (NPC) remain elusive. Here, we first confirmed that levels primary metastatic NPC tissues were significantly increased compared with those...
Abstract Long noncoding RNAs (lncRNAs) have important roles in various biological processes. Our previous work has revealed that dedifferentiation of retinal pigment epithelium (RPE) cells contributes to the pathology age-related macular degeneration (AMD). Herein, we show lncRNAs RPE differentiation. We used microarray identify lncRNA expression profiles human induced pluripotent stem (hiPSCs) and hiPSC-derived cells. A total 217 differentially expressed along with differentiation were...
To evaluate reasons for non-compliance with post-cataract surgical follow-up in rural China, and assess the impact of incentives on improving compliance.Patients having undergone cataract surgery more than 3 months previously at training hospitals Guangdong were invited by telephone advertisements to a hospital-based study examination, compensation travel costs (US$7). Information prior post-surgical follow up was collected questionnaire hospital or telephone. Logistic regression used...
The aim of this study was to investigate the genetic basis and pathogenic mechanism variable maculopathies, ranging from mild photoreceptor degeneration central areolar choroidal dystrophy, in a five-generation family.Clinical characterizations, whole-exome sequencing, genome-wide linkage analysis were carried out on family. Zebrafish models used pathogenesis GUCA1A mutations.A novel mutation, p.R120L, identified family predicted alter tertiary structure guanylyl cyclase-activating protein...
Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) A549 cells. However, precise molecular mechanism of TGF-β1-induced EMT remains unclear. This aimed to investigate function and interacted microtubule-associated protein 1B light chain (MAP 1B-LC1) EMT.Immunohistochemistry was used detect expression non-small-cell lung cancer (NSCLC). GST-pull down...
Abstract The c-Myc and human telomerase reverse transcriptase gene (hTERT) are frequently deregulated overexpressed in malignancy. hTERT activity is induced by strategies designed to inhibit expression cancer cells may have considerable therapeutic value. We used a short hairpin RNA Colo 320 validated its effect on cell proliferation. In this study, four c-Myc-shRNA vectors were constructed introduced into cells. effects of silencing tumor growth was assessed soft agar assay DNA synthesis...
Neuroinflammation is the leading cause of neurological sequelae in ischemic stroke. Recently, we reported that anti-inflammatory mediator annexin A1 (ANXA1) favored microglial M2 polarization brain injury. The purpose this study was to investigate electroacupuncture (EA) treatment and its potentially ANXA1-mediated effects middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model stroke.Treatment with EA consisted dense-sparse frequencies (alternating 4 Hz sparse waves for 1.5 s 16...
Human colon cancer is the leading cause of death in both men and women worldwide. The c-Myc gene frequently deregulated overexpressed this malignancy, strategies designed to inhibit expression cells may have considerable therapeutic value. We design use short hairpin RNA (shRNA) Colo 320 validat its effect on cell proliferation. In study, four c-Myc-shRNA vectors were constructed introduced into cells, cycle apoptotic analyzed by flow cytometry. effects silencing tumor-cell growth was...
Mortality factor 4‑like 1 (MORF4L1) is a member of subgroup histone acetyltransferases and belongs to the mortality on chromosome 4 (MORF4) class proteins. However, role MORF4L1 in cancers largely unknown. Using reverse transcription‑quantitative polymerase chain reaction published datasets, present study demonstrated that expression decreased several cancers, including nasopharyngeal carcinoma (NPC). Additionally, methylation rate promoter was identified be significantly higher tumour cells...
Purpose: To study the role of lysine-specific demethylase 1 (LSD1) in retinoblastoma (RB) growth and to determine whether LSD1 inhibitor SP2509 can inhibit RB progression. Methods: We detected levels 12 tissue samples, two cell lines (Y79 Weri-RB1), a retinal pigment epithelium line (ARPE-19). Overexpression or knockdown was performed examine cancer survival. In vitro vivo experiments were conducted detect antitumor effect SP2509, mechanism examined by RNA sequencing Western blot. Results:...
WT161 is a recently discovered histone deacetylase 6 (HDAC6) inhibitor which shows anti-tumor effects on multiple myelomas and breast cancer. However, the role of in retinoblastoma remains unclear. The aim this study to explore its underlying mechanisms.The anti-proliferation cells was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay soft agar colony formation assay. Cell apoptosis analyzed flow cytometer. DDP synergistic effect evaluated by isobologram...
We investigated the effects of alpha-fetoprotein (AFP) gene silencing on Survivin expression in HepG2 cells. Small interfering RNA technology was used to downregulate AFP An enzyme-linked immunosorbent assay measure concentration supernatant before and after transfection. MTT detect cell proliferation activity performed flow cytometric analysis apoptosis rate, reverse transcription-polymerase chain reaction mRNA levels Forty-eight hours transfection, experimental group significantly...
The c-Myc and human telomerase reverse transcriptase gene (hTERT) are frequently deregulated overexpressed in malignancy. hTERT activity is induced by strategies designed to inhibit expression cancer cells may have considerable therapeutic value. We used a short hairpin RNA Colo 320 validated its effect on cell proliferation. In this study, four c-Myc-shRNA vectors were constructed introduced into cells. effects of silencing tumor growth was assessed soft agar assay DNA synthesis MTT...