A5007977481- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Laser-Matter Interactions and Applications
- Cancer-related Molecular Pathways
- Acupuncture Treatment Research Studies
- Cell death mechanisms and regulation
- Acute Ischemic Stroke Management
- Pain Mechanisms and Treatments
- Magnesium in Health and Disease
- Healthcare and Venom Research
- Laser Design and Applications
- Inflammatory Bowel Disease
- Advanced Fiber Laser Technologies
- Spectroscopy and Quantum Chemical Studies
- Protease and Inhibitor Mechanisms
- Tryptophan and brain disorders
- IL-33, ST2, and ILC Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Endoplasmic Reticulum Stress and Disease
- Immunotherapy and Immune Responses
- Neurological Disease Mechanisms and Treatments
- Terahertz technology and applications
- Sirtuins and Resveratrol in Medicine
- Blood Coagulation and Thrombosis Mechanisms
University of Alberta
2023-2025
Huazhong University of Science and Technology
2011-2024
Wuhan National Laboratory for Optoelectronics
2020-2024
First Affiliated Hospital of Zhengzhou University
2024
Institute of Virology of the Slovak Academy of Sciences
2023
Ministry of Education of the People's Republic of China
2023
Institute of Infection and Immunity
2023
Amgen (United States)
2006-2018
Guangzhou Medical University
2018
Hong Kong Polytechnic University
2018
Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations SOST, the gene encoding sclerostin. Based on these data, sclerostin has emerged as key negative regulator of mass. We generated SOST knockout (KO) mice to gain more detailed understanding effects deficiency bone.Gene targeting was used inactivate and generate line KO mice. Radiography, densitometry, microCT, histomorphometry, mechanical testing were characterize impact male female Comparisons...
Abstract RANKL is a TNF family member that mediates osteoclast formation, activation, and survival by activating RANK. The proresorptive effects of are prevented binding to its soluble inhibitor osteoprotegerin (OPG). Recombinant human OPG-Fc recognizes from multiple species reduced bone resorption increased volume, density, strength in number rodent models disease. clinical development was discontinued favor denosumab, fully monoclonal antibody specifically inhibits primate RANKL. Direct...
The p53 tumor-suppressor gene encodes a growth-regulatory protein that has been implicated in programmed cell death. To investigate the possible role of neuronal death, we studied expression associated with excitotoxicity adult rat brain. Within hours systemic administration glutamate analogue kainic acid, mRNA levels were increased neurons exhibiting morphological features damage within kainate-vulnerable brain regions. A similar distribution was found for DNA as evidenced by situ...
T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of cells, the function its ligands, PDL1 PDL2, is still controversial. In this study, we created PDL2-deficient mouse to characterize in tolerance. Antigen-presenting cells from PDL2-/- mice were found be more potent vitro over wild-type controls, which depended on PD-1. Upon immunization with chicken ovalbumin, exhibited increased CD4(+) CD8(+) vivo when compared WT...
Background Paclitaxel is commonly used as a cancer chemotherapy drug that frequently causes peripheral neuropathic pain. Inflammasome multiprotein complex consisting of Nod-like receptor proteins (NLRPs), apoptosis-associated speck-like protein, and caspase-1, which functions to switch on the inflammatory process release interleukin-1β. Growing evidences have supported interleukin-1β critical in enhancing paclitaxel-induced However, whether activation NLRP3 inflammasome nerve contributes...
Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered...
Effects of nicotine treatment (4.5 mg/kg nicotine-free base/day administered s.c. by osmotic minipumps for 14 days) on focal ischemic stroke and expression tissue plasminogen activator (t-PA) inhibitor-1 (PAI-1) in cerebral microvessels were studied rats vivo using a reversible (1 h) middle artery occlusion model. Plasma levels its major metabolite cotinine after days 88 364 ng/ml, respectively. Nicotine resulted 35–40% ( p <0.001) decrease the blood flow periphery core during...
Significance Intrinsic bursts and rhythmic burst discharges are elicited by activation of T-type Ca 2+ channels in the thalamic reticular nucleus (TRN). TRN believed to be critical for generation maintenance thalamocortical oscillations, leading spike-and-wave (SWDs) on cortical electroencephalogram, which hallmarks absence seizures. Using knockout mice that completely lack bursts, however, we show increased tonic firing seems sufficient drug-induced SWD generation. These results call into...
The p53 tumor suppressor gene has been implicated in apoptotic cell death. present study was conducted to investigate whether expression of protein is increased association with kainic acid-induced neuronal apoptosis. Adult male Sprague-Dawley rats were treated systemically the glutamate analog acid, and sacrificed either 4 or 30 h after onset seizure activity. Immunohistochemistry performed on paraffin-embedded sections using an anti-p53 polyclonal antibody. At both time points,...
REDOX factor-1 (Ref-1) is a dual-function protein involved in both DNA repair and transcriptional regulation. Ref-1 modulated by cerebral ischemia other oxidative stressors, also regulates the DNA-binding activities of transcription factors implicated Alzheimer's disease (AD)-related neurodegeneration. The present study examined expression AD hippocampus immunohistochemistry. Although immunostaining was relatively low control brain sections, senile plaques plaque-like structures were...
TRPM7, a divalent cation channel, plays an important role in neurons damaged from cerebral ischemia due to permitting intracellular calcium overload. This study aimed explore whether magnesium was transported via TRPM7 channel into the space of rat hippocampal after 1 h oxygen-glucose deprivation (OGD) and acute chemical (CI) by using methods Mg(2+) fluorescent probe Mag-Fura-2 detect concentration ([Mg(2+)](i)) flame atomic absorption spectrometry measure extracellular ([Mg(2+)](o)). The...
Postherpetic neuralgia (PHN) is a complication of herpes zoster viral infection. Its main manifestations are continuous or intermittent burning-like and electroshock-like pain in the affected nerves. Electroacupuncture (EA) widely used clinical treatment exerts effects alleviating neuropathic pain. In this study, we investigated effect underlying mechanism EA on PHN. Sprague-Dawley rats were treated with resiniferatoxin (RTX) to establish PHN model subjected and/or miR-223-3p overexpression...
Abstract Background We have been investigating the role of viral infections in development inflammatory bowel disease (IBD) genetically predisposed individuals. Using SvEv IL10 -/- model colitis, we found evidence mouse mammary tumor virus (MMTV) infection and modulated with combination antiretroviral therapy. Reducing MMTV RNA colon lowered inflammation, cytokine levels, microbial dysbiosis. Our results showed superantigen (SAg) activity, which uses to replicate lymphocytes. also exploits...
PREVIOUS WORK HAS shown that tissue plasminogen activator (tPA) is a key enzyme in the control of fibrinolysis within vascular system. The sources brain tPA and mechanisms by which secretion production occur cerebral microcirculation are not well established. In this study, expression was investigated capillaries capillary-depleted isolated from cortices 4- to 5-week-old rats guinea pigs. both species, single band Mr 67,000 detected Western blot analysis. signal absent brain. These results...
OBJECTIVE The unraveling of the elaborate brain networks that control glucose metabolism presents one current challenges in diabetes research. Within central nervous system, hypothalamus is regarded as key area to regulate energy homeostasis. aim present study was investigate hypothalamic mechanism involved hyperglycemic effects neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP). RESEARCH DESIGN AND METHODS Endogenous production (EGP) determined during...
We propose and theoretically demonstrate a method to generate the circularly polarized supercontinuum with three-color electric fields. The field is synthesized from an orthogonally two-color (OTC) laser infrared gating field. All driving pulse durations are extended 40 fs. that imposes curved trajectories for ionized electrons extends time interval between each harmonic emitting. Through adjusting intensity ratios among three components of field, nearly circular isolated attosecond can be generated.
Background and Purpose Tissue plasminogen activator (TPA) is normally expressed in rat brain capillaries. This study examines the expression of TPA capillaries diabetic rats relation to focal ischemic injury. Methods Diabetes type 1 was induced by streptozotocin for 7 days. Acute hyperglycemia 50% dextrose. Expression determined Western blot reverse transcription-polymerase chain reaction analyses. Focal stroke produced hour reversible middle cerebral artery occlusion. Physiological...
Mice with null mutations of ciliary neurotrophic factor (Cntf) receptor alpha (Cntf-Rα), or cytokine-like 1 (Clf), one component Cntf-II (a heterodimeric Cntf-Rα ligand), die as neonates from motor neuron loss affecting the facial nucleus and ventral horn lumbar spinal cord. Exposure to cardiotrophin-like cytokine (Clc), other putative element, supports survival in vitro ovo. Confirmation that Clc ablation induces an equivalent phenotype Clf deletion would support a role for functional...