A5101516435- S100 Proteins and Annexins
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral-associated cancers and disorders
- Advanced Nanomaterials in Catalysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Genomics, phytochemicals, and oxidative stress
- Energy Efficiency and Management
- Polyamine Metabolism and Applications
- Carbon and Quantum Dots Applications
- Radiopharmaceutical Chemistry and Applications
- Bone Metabolism and Diseases
- Retinoids in leukemia and cellular processes
- Bone health and osteoporosis research
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Vitamin K Research Studies
- Advanced Glycation End Products research
- Enzyme Catalysis and Immobilization
- Breast Cancer Treatment Studies
- Herpesvirus Infections and Treatments
- Cancer and Skin Lesions
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
Huazhong University of Science and Technology
2018-2024
Nanjing Drum Tower Hospital
2024
Nanjing University of Chinese Medicine
2024
Ministry of Education of the People's Republic of China
2018-2023
Zhengzhou University
2019-2022
Fudan University
2014
Louisiana State University Health Sciences Center Shreveport
2004
Louisiana State University in Shreveport
2001-2004
Chinese Academy of Medical Sciences & Peking Union Medical College
1981
Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated could promote beneficial phenotype polarization of microglia. Mechanistically, suppressed nuclear factor κB production proinflammatory mediators. Further study revealed targeted IκB kinase (IKK) complex selectively enhanced IKKα degradation....
Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered...
Abstract The subcellular location of annexin A1 (ANXA1) determines the ultimate fate neurons after ischemic stroke. ANXA1 nuclear translocation is involved in neuronal apoptosis cerebral ischemia, and extracellular also associated with regulation inflammatory responses. As factors mechanism that influence remain unclear, studies aiming to determine clarify role as a cell ‘regulator’ within cells are critically needed. In this study, we found intracerebroventricular injection recombinant...
Dense extracellular matrix (ECM) severely impedes the spread of drugs in solid tumors and induces hypoxia, reducing chemotherapy efficiency. Different proteolytic enzymes, such as collagenase (Col) or bromelain, can directly attach to surface nanoparticles improve their diffusion, but method ligation may also impair enzymatic activity due conformational changes blockage active site. Herein, a "nanoenzyme capsule" was constructed by combining nanocapsules (Col-nc) with heavy-chain ferritin...
Abstract Purpose: Overexpression of eIF4E in surgical margins head and neck cancer patients is an independent risk factor for recurrence. We hypothesize that overexpressed functionally active tumor through activation the Akt/mammalian target rapamycin (mTOR) pathway Experimental Design: Western blots and/or immunohistochemistry were performed to determine whether phosphorylation mTOR its downstream molecules eIF4E-binding protein-1 (4E-BP1) p70 S6 kinase upstream modulator mTOR, Akt,...
β-Amyloid (Aβ) aggregation and oxidative stress are primary pathological features of Alzheimer's disease (AD). Combination therapies that target brain tissue corporately address these main factors required for effective AD treatment. Here, we developed a multifunctional liposome delivery system (KLVFF@LIP-CeO2) co-delivery Aβ-targeted KLVFF reactive oxygen species (ROS)-responsive Ceria (CeO2) through intranasal administration. After Aβ1-42-induced ROS apoptosis in HT22 cells, KLVFF@LIP-CeO2...
Induction of Epstein-Barr virus (EBV) early antigen after treatment with various combinations croton oil and n-butyrate was markedly inhibited by retinoids 7901, 7902, Ro 10-9359 11-1430. Possible administration to capsid IgA antibody-positive individuals in high-risk areas for nasopharyngeal carcinoma prevent EBV activation development this cancer is discussed.
Epstein-Barr virus (EBV) replication and transcription activator (Rta) is an immediate-early factor that mediates the switch from latent to lytic infection. DNA viruses often modulate function of critical cell cycle proteins maximize efficiency replication. Here we have examined effect Rta on progression. Cell analysis revealed induced HeLa cells in G0/G1-phase reenter S-phase. Analysis expression pattern a key set regulators inhibited Rb p53 E2F1. These findings suggest plays active role...
Breast cancer treatment has been challenging all the time because cells have multiple signaling pathways; so, breast still remains a threat to lives and health of many patients. While common single drug therapies inhibit only one pathway, combination mechanisms offers potential simultaneously suppress targets pathways kill more effectively. It is reported that autophagy caused by inducers apoptosis some chemotherapeutic drugs can promote ferroptosis extent; herein, we combined these three...
Oxidative stress is believed to play critical pathophysiological roles in ischemic brain injury, and the nuclear factor erythroid 2-related 2 (Nrf2) signaling pathway recognized as most crucial endogenous antioxidant damage route. Some research have demonstrated that Nrf2 oxidative after stroke, but underlying mechanism are not fully elucidated. This study reveals modified by SUMOylation identifies Sentrin/SUMO-specific protease 6 (SENP6) a negative regulator of SUMOylation. Notably, SENP6...
Integrated energy services (IES) as commodities traded in the market. Clear utility is conductive to positive development of IES In this paper, an exponential function introduced characterize basic terms cost utility, stability and destabilization recovery utility. The value-added depicted by consumption preference environment-friendly integrated saving By combining obtained clarify psychological perception customers towards provided service providers. Finally, six industrial users a...