A5079367600- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Cholinesterase and Neurodegenerative Diseases
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- RNA Research and Splicing
- Neuroendocrine regulation and behavior
- Reproductive System and Pregnancy
- Genomics, phytochemicals, and oxidative stress
- S100 Proteins and Annexins
- Cellular transport and secretion
- Medicinal Plants and Neuroprotection
- Neurology and Historical Studies
- Estrogen and related hormone effects
- Immune Response and Inflammation
- Reproductive Biology and Fertility
- RNA regulation and disease
- Customer Service Quality and Loyalty
- Outsourcing and Supply Chain Management
- Adipose Tissue and Metabolism
Huazhong University of Science and Technology
2014-2025
Wuhan Union Hospital
2025
Ministry of Education of the People's Republic of China
2023
Jiangsu University
2021
Yixing People's Hospital
2021
National Chung Hsing University
2009
Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered...
The neuron-glia cross-talk is critical to brain homeostasis and particularly affected by neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a hallmark in Alzheimer’s disease (AD), remains elusive. In this study, we identified excessively elevated neuronal expression of adenosine receptor 1 (Adora1 or A1R) 3×Tg mice, MAPT P301L (rTg4510) patients with AD, patient-derived neurons. up-regulation A1R...
Abstract Dietary high salt intake is increasingly recognized as a risk factor for cognitive decline and dementia, including Alzheimer’s disease (AD). Recent studies have identified population of disease‐associated astrocytes (DAA)‐like closely linked to amyloid deposition tau pathology in an AD mouse model. However, the presence role these high‐salt diet (HSD) models remain unexplored. In this study, it demonstrated that HSD significantly induces enhanced reactivity DAA‐like hippocampal CA3...
Summary The two estrogen receptors ( ER s), α and β, mediate the diverse biological functions of estradiol. Opposite effects β have been found in estrogen‐induced cancer cell proliferation differentiation as well memory‐related tasks. However, whether these opposite are implicated pathogenesis Alzheimer's disease AD ) remains unclear. Here, we find that play contrasting roles regulating tau phosphorylation, which is a pathological hallmark . increases expression miR‐218 to suppress protein...
Abstract Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), which the deficits melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed hippocampus mediates biological functions melatonin. It known that application protective to abnormalities AD. However, whether MT2 involved neuroprotection underlying mechanisms are not clear. Here, we first dramatically reduced compartment upon...
Cholinergic degeneration is one of the key pathological hallmarks Alzheimer’s disease (AD), a condition that characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) secreted in brain regions receive projections from basal forebrain cholinergic neurons. The trophic effects NGF rely on appropriate maturation its precursor, proNGF. ratio proNGF/NGF known to be increased patients with AD; however, mechanisms underlie this observation have yet elucidated. Here, we...
Abstract Competitive interactions are pervasive within biological populations, where individuals engage in fierce disputes over vital resources for survival. Before the establishment of a social hierarchy population, this competition becomes even more intense. Historical experiences significantly influence competitive performance; with history persistent loss less likely to initiate attacks or win escalated contests. However, it remains unclear how historical directly affects evolution...
Tauopathies are a class of neurodegenerative diseases that characterized by pathological aggregation tau protein, which is accompanied synaptic disorders. However, the role in endocytosis, fundamental process transmission, remains elusive. Here, we report forced expression human (hTau) mouse cortical neurons impairs endocytosis decreasing level GTPase dynamin 1 via disruption miR-132-MeCP2 pathway; this can also be detected brains Alzheimer's patients and hTau mice. Our results provide...
Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer's disease (AD), while how initiate early cognitive stimulation is unclear. Given that the immature more sensitive environmental stimuli and dynamics decrease with ageing, we reasoned it would be effective against AD as fetal period. After conception, maternal transgenic mice (3 × Tg AD) were exposed gestational environment enrichment (GEE) until day of delivery. The capacity offspring was...
The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing principal components analysis (PCA)-based approach, we differentiated the mice into extinction-resistant and susceptible groups. We identified that elevated synapsin 2a (Syn2a) infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading an excitatory/inhibitory imbalance BLA region causing resistance. Overexpression or silencing Syn2a...
Alzheimer’s disease (AD) was characterized by the presence of neurofibrillary tangles and senile plaques. Although melatonin plays an important role in AD, its mechanism is still unknown. In this study, we found obvious cognition damage receptor 2 knockout mice (MT2KO) double (DKO), but not 1 (MT1KO). To explore in-depth, attempted to determine levels metabolites amyloid-β peptide (Aβ). A high level Cho/tCr (choline/total creatine) detected MT2KO MT1KO nuclear...
Tau pathology, including aberrant tau hyperphosphorylation, aggregation, and mislocalization, is implicated in many neurodegenerative disorders, Alzheimer’s disease (AD), which the most prevalent dementia among elderly. A better understanding of molecular mechanisms underlying pathology should help advance therapies for diseases. Perturbations cyclic adenosine monophosphate (cAMP)-dependent signaling play an important role pathophysiology numerous neurological EPAC2 intracellular...
Abstract Sporadic or late-onset Alzheimer’s disease (LOAD) accounts for more than 95% of (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci LOAD, numerous suggest that many adverse environmental factors, such as social isolation, are with an increased dementia. However, the underlying mechanisms isolation in AD progression remain elusive. In current study, we found 7 days could trigger pattern separation impairments...
Hosting weddings, graduation dinners, teacher appreciation banquets, family banquets and other activities at hotels are very popular in mainland China, the income of weddings has been considered as a major revenue generator for hotels. With high demand Yixing Hotel opened three new banquet halls 2018 started to use outsourcing employees assist serving wedding banquets. This study collected history data hotel internal employee surveys customer identify impact labor on customers terms...
Alzheimer's disease (AD) is characterized by brain deposition of the amyloid beta-protein (A β) and Tau hyperphosphorylation that are associated with cognitive impairment dementia. Many factors involved in pathologies AD, like protein kinase, transcriptional factors, etc. While some evidence has been found for understanding genetic molecular mechanisms role small noncoding RNAs occurrence development AD remains to be investigated. Using Morris water maze, contextual fear conditioning,...