A5101966219- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Building materials and conservation
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Cultural Heritage Materials Analysis
- interferon and immune responses
- Pharmaceutical Practices and Patient Outcomes
- Sirtuins and Resveratrol in Medicine
- Video Analysis and Summarization
- Glaucoma and retinal disorders
- Breastfeeding Practices and Influences
- Advanced Algorithms and Applications
- Ubiquitin and proteasome pathways
- Pharmacy and Medical Practices
- Satellite Communication Systems
- Medical Image Segmentation Techniques
- Inflammation biomarkers and pathways
- Infant Nutrition and Health
- Inflammasome and immune disorders
- Heavy metals in environment
- Silicon and Solar Cell Technologies
- Vitamin K Research Studies
- Remote Sensing and Land Use
- NF-κB Signaling Pathways
Jiangyin Traffic Planning Survey & Design Institute (China)
2024
Huazhong University of Science and Technology
2004-2024
Tongji Hospital
2021-2024
Fudan University
2023-2024
Xi'an Jiaotong University
2024
Qilu Hospital of Shandong University
2023-2024
Lanzhou University
2024
Minhang District Central Hospital
2024
State Administration of Cultural Heritage
2024
Chengdu Medical College
2024
Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated could promote beneficial phenotype polarization of microglia. Mechanistically, suppressed nuclear factor κB production proinflammatory mediators. Further study revealed targeted IκB kinase (IKK) complex selectively enhanced IKKα degradation....
Abstract Excessive and unresolved neuroinflammation is a key component of the pathological cascade in brain injuries such as ischemic stroke. Tripartite motif-containing 45 (TRIM45) ubiquitin E3 ligase involved various critical biological processes. However, role TRIM45 cerebral ischemia remains unknown. Here, we found that protein was highly expressed peri-infarct areas mice subjected to reperfusion injury induced by middle artery occlusion. This study systemically evaluated putative...
Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered...
Abstract The subcellular location of annexin A1 (ANXA1) determines the ultimate fate neurons after ischemic stroke. ANXA1 nuclear translocation is involved in neuronal apoptosis cerebral ischemia, and extracellular also associated with regulation inflammatory responses. As factors mechanism that influence remain unclear, studies aiming to determine clarify role as a cell ‘regulator’ within cells are critically needed. In this study, we found intracerebroventricular injection recombinant...
Abstract Background Microglia-induced excessive neuroinflammation plays a crucial role in the pathophysiology of multiple neurological diseases, such as ischaemic stroke. Controlling inflammatory responses is considered promising therapeutic approach. Sirtuin 5 (SIRT5) mediates lysine desuccinylation, which involved various critical biological processes, but its stroke remains poorly understood. This research systematically explored function and potential mechanism SIRT5 microglia-induced...
Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by acute elevation, we found that expression protein was decreased. An induction liver X receptor agonist TO901317 reduced ganglion cell (RGC) apoptosis after IR promoted membrane...
Rationale: Annexin-A1 (ANXA1) has previously been proposed to play a crucial role in neuronal apoptosis during ischemic stroke injury. Our recent study demonstrated that ANXA1 was modified by SUMOylation, and this modification greatly weakened after cerebral ischemia, but its effect on death the underlying mechanism have not fully elucidated. Methods: Mice subjected middle artery occlusion were established as animal model primary cultured neurons treated with oxygen-glucose deprivation...
Abstract Background Excessive and unresolved neuroinflammation plays an important role in the pathophysiology of many neurological disorders, such as ischemic stroke, yet there are no effective treatments. Tripartite motif-containing 67 (TRIM67) a crucial control inflammatory disease pathogen infection-induced inflammation; however, TRIM67 cerebral ischemia‒reperfusion injury remains poorly understood. Results In present study, we demonstrated that expression level was significantly reduced...
Abstract Previous data have suggested that the nuclear translocation of annexin 1 (ANXA1) is involved in neuronal apoptosis after ischemic stroke. As mechanism and function ANXA1 migration remain unclear, it important to clarify how performs its role as an ‘regulator’ nucleus. Here we report importazole (IPZ), importin β (Imp )-specific inhibitor, decreased accumulation reduced rate death induced by oxygen-glucose deprivation–reoxygenation (OGD/R). Notably, interacted with Bid...
Previous data have reported that Sentrin/SUMO-specific protease 6 (SENP6) is involved in ischaemic brain injury and induces neuronal apoptosis after cerebral ischaemia, but the role of SENP6 microglia-induced neuroinflammation its underlying mechanism remain poorly understood. This research systematically explored function potential stroke. We first identified an increased protein level microglia ischaemia. Then, we demonstrated promoted detrimental microglial phenotype polarization....
Background Human papillomaviruses ( HPV s) are strongly associated with the development of cervical carcinoma, and distribution genotypes varies regionally. Methods To investigate characteristics different infection in women Wuhan, China, a total 13 775 patients were enrolled over 2 years. Results Of these, 2436 infected s, rate was 17.68%. The high‐risk HR ‐ ) significantly higher (13.96%) than that single low‐risk LR ; 3.72%). Among infections, most common genotype 52 an 4.23%, followed by...
Annexin A1 (ANXA1) is a protein known to have multiple roles in the regulation of inflammatory responses. In this study, we find that after oxygen glucose deprivation/reoxygenation (ODG/R) injury, activated PKC phosphorylated ANXA1 at serine 27 residue (p27S-ANXA1), and promoted translocation p27S-ANXA1 nucleus BV-2 microglial cells. This turn induced cells produce large amounts pro-inflammatory cytokines. The phenomenon could be mimicked by either transfecting mutant form with its converted...
Recent evidences have implicated that SENP3 is a deSUMOylase which possesses neuronal damage effects in cerebral ischemia. However, its role microglia remains poorly understood. Here, we found was upregulated the peri-infarct areas of mice following ischemic stroke. Furthermore, knockdown significantly inhibits expression proinflammatory cytokines and chemokines microglial cells. Mechanistically, can bind then mediated deSUMOylation c-Jun, activated transcriptional activity, ultimately...
Numerous studies on the weathering of rock heritages mainly focus surface layer or localized features (such as efflorescence and cracking) in individual heritages, without considering temporal spatial scale effects mineral itself. Therefore, existing have had difficulty explaining patterns at a large regional watershed scale). To overcome previous limitations, this study analyzed water chemistry, mechanical, mineralogical, geochemical properties Quaternary conglomerate/sediment profiles...
Abstract Stroke is a major public health concern worldwide. The lack of effective therapies heightens the need for new therapeutic agents. Previous study identified sirtuin 5 (SIRT5) as positive regulator microglia‐induced excessive neuroinflammation following ischemic stroke. Interventions targeting SIRT5 should therefore alleviate and protect against Here, we synthesized membrane‐permeable peptide specifically bound to through chaperone‐mediated autophagy motif (Tat‐SIRT5‐CTM) examined its...
Hypoxic ischemic encephalopathy (HIE) refers to neonatal hypoxic brain injury caused by severe asphyxia during the perinatal period. With a high incidence rate and poor prognosis, HIE accounts for 2.4% of global disease burden, imposing heavy burden on families society. Current clinical treatment primarily focuses symptomatic management supportive care. Therefore, developments effective strategies new drug formulations are critical improving prognosis patients. In order protect compromised...
Abstract Background In the UK certain groups with pre-disposing conditions are eligible for vaccination pneumococcal polysaccharide vaccine (PPV23). Uptake of in these individuals has not been reported 10 years. Hence this study investigated rates vaccination, time to since diagnosis, and factors associated aged 18–64 years underlying medical conditions. Methods A retrospective database analysis was conducted using Clinical Practice Research Datalink (CPRD). Individuals 18 64 who had a...