A5070332911- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Circular RNAs in diseases
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Nuclear Receptors and Signaling
- Plant Gene Expression Analysis
- Genetics and Neurodevelopmental Disorders
- Natural Antidiabetic Agents Studies
- Vascular anomalies and interventions
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Sirtuins and Resveratrol in Medicine
- Wound Healing and Treatments
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Retinoids in leukemia and cellular processes
Jining Medical University
2019-2024
Huazhong University of Science and Technology
2015-2017
Ministry of Education of the People's Republic of China
2017
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome (ALP) are the two major protein degradation pathways, which critical for proteostasis. Growing evidence indicates that proteasome inhibition-induced ALP activation is an adaptive response. Transcription Factor EB (TFEB) a master regulator of ALP. However, characteristics TFEB its role in not fully investigated. Here we reported half-life around 13.5 h neuronal-like cells, degraded through both non-neuronal cells. Moreover, impairment...
Circular RNAs (circRNAs) play an important role in many neurological diseases and can serve as biomarkers for these diseases. However, the information about circRNAs Parkinson disease (PD) remained limited. In this study, we aimed to determine expression profile PD patients discuss significance of diagnosis PD.Using RNA-sequencing peripheral blood RNAs, showed that a significant number mRNAs or were differentially expressed between normal controls (NCs), which included 273 up-regulated 493...
Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson's disease (PD). Among mutations, LRRK2 c.4883G>C (R1628P) variant was identified to a significant association risk of PD ethnic Han-Chinese populations. But molecular pathological mechanisms R1628P mutation is still unknown.Unlike other mutants Roc-COR-Kinase domain, didn't alter activity and promote neuronal death directly. increased binding affinity...
Parkinson's disease is a common neurodegenerative with movement disorders associated the intracytoplasmic deposition of aggregate proteins such as α-synuclein in neurons. As one major intracellular degradation pathways, autophagy-lysosome pathway plays an important role eliminating these proteins. Accumulating evidence has shown that upregulation may contribute to clearance aggregates and protect against degeneration dopaminergic neurons disease. Moreover, multiple genes pathogenesis are...
Parkinson's disease (PD) is an irreversible and progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons substantia nigra pars compacta. Growing evidence indicates that endoplasmic reticulum stress a hallmark PD; however, its exact contribution to process remains poorly understood. Here, we used molecular biology methods RNA-Seq analysis explored unexpected role spliced X-Box binding protein 1 (XBP1s) in nervous system. In this study, determined...
α-Synuclein is an abundantly expressed neuronal protein that at the center of focus in understanding a group neurodegenerative disorders called synucleinopathies, which are characterized by intracellular presence aggregated α-synuclein. However, mechanism α-synuclein biology synucleinopathies pathogenesis not fully understood. In this study, mice overexpressing human A30P*A53T were evaluated motor behavior test and count TH-positive neurons, then two-dimensional liquid chromatography-tandem...
Diabetic foot ulcer (DFU) is considered as one of the most serious and prevailing complications diabetes mellitus, while it major cause amputations in diabetic patients. Herein, we reported an acquired severe traumatic DFU with intermediate cuneiform hairline fracture displacement a 55-year old male (Grade IV Wagner classification; Grade III IWGDF classification). The Pseudomonas aeruginosa was identified pus culture. Data antibiotic susceptibility testing indicated that isolates were...
Multiple risk factors of stroke are associated with telomere length shortening. Although leukocyte (LTL) is shorter in patients stroke, the heterogeneity high. Risk may be differentially LTL male and female contributing to heterogeneity. However, gender difference associations between has not been investigated. In this study, we investigated 312 patients. Real-time quantitative PCR was used determine relative LTL, multiple linear regression analysis applied for association analyses. We found...
Isolated congenital coronary artery fistula (ICCAF) is an exceedingly rare anomaly in which there a direct abnormal connection between and other cardiac chambers or any of great vessels. The left circumflex (LCX) the least common source ICCAF. Here we reported case large ICCAF originated from LCX 9-year-old boy. He presented fatigability, murmurs NYHA class II. Echocardiography CT revealed that aneurysmal dilatation along with dilated sinus entered into right atrium (RA) through vein....