A5014522956- Diet and metabolism studies
- MicroRNA in disease regulation
- Gut microbiota and health
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Nail Diseases and Treatments
- T-cell and B-cell Immunology
- Plant and Fungal Interactions Research
- Single-cell and spatial transcriptomics
- Genomics and Rare Diseases
- Remote-Sensing Image Classification
- Meningioma and schwannoma management
- Animal Virus Infections Studies
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- Antibiotic Resistance in Bacteria
- Flavonoids in Medical Research
- Gene expression and cancer classification
BGI Group (China)
2013-2025
China National GeneBank
2019-2025
BGI Research
2023-2025
Botswana Geoscience Institute
2021
Beijing Graphene Institute
2020
South China University of Technology
2018
Air Force Medical University
2014
Biological age (BA) has been proposed to evaluate the aging status instead of chronological (CA). Our study shows evidence that there might be multiple "clocks" within whole-body system: systemic drivers/clocks overlaid with organ/tissue-specific counterparts. We utilize multi-omics data, including clinical tests, immune repertoire, targeted metabolomic molecules, gut microbiomes, physical fitness examinations, and facial skin estimate BA different organs (e.g., liver, kidney) systems...
Neurodegenerative diseases encompass a wide variety of pathological conditions caused by loss neurons in the central nervous system (CNS) and are severely debilitating. Exosome contains bio-signatures great diagnostic therapeutic value. There is proof that exosomal proteins can be biomarkers for Alzheimer's disease (AD) Parkinson's (PD). MicroRNAs exosome has potential to an important source neurodegenerative diseases. Here, we report microRNA performance human plasma small RNA sequencing. A...
The human skin microbiota is considered to be essential for homeostasis and barrier function. Comprehensive analyses of its function would substantially benefit from a catalog reference genes derived metagenomic sequencing. existing the microbiome based on samples limited individuals single cohort genomes, which limits coverage global diversity.In present study, we have used shotgun metagenomics newly sequence 822 Han Chinese, were subsequently combined with 538 previously sequenced North...
Small extracellular vesicle (sEV) is an emerging source of potential biomarkers Alzheimer's disease (AD), but the role microRNAs (miRNAs) in sEV not well understood. In this study, we conducted a comprehensive analysis sEV-derived miRNAs AD using small RNA sequencing and coexpression network analysis. We examined total 158 samples, including 48 from patients, patients with mild cognitive impairment (MCI), 62 healthy controls. identified miRNA module (M1) that was strongly linked to neural...
Abstract Human aging is invariably accompanied by a decline in renal function, process potentially exacerbated uremic toxins originating from gut microbes. Based on registered household Chinese Guangxi longevity cohort ( n = 151), we conducted comprehensive profiling of the microbiota and serum metabolome individuals 22 to 111 years age validated findings two independent East Asian cohorts (Japan 330, Yunnan 80), identifying unique age‐dependent differences metabolome. We discovered that...
Abstract Neuroligin-3 ( Nlgn3 ) is an autism-associated cell-adhesion molecule that interacts with neurexins and robustly expressed in both neurons astrocytes. Neuronal essential regulator of synaptic transmission but the function astrocytic largely unknown. Given high penetrance mutations autism emerging role astrocytes neuropsychiatric disorders, we here asked whether might shape neural circuit properties cerebellum similar to neuronal . Imaging tagged protein produced by...
Accurate genotyping is important for genetic testing. Sanger sequencing-based typing the gold standard genotyping, but it has been underused, due to its high cost and low throughput. In contrast, short-read sequencing provides inexpensive high-throughput sequencing, holding great promise reaching goal of cost-effective genotyping. However, length paucity appropriate methods, pose a major challenge. Here, we present RCHSBT—reliable, sequence based pipeline—which takes short reads as input,...
Circular RNAs (circRNAs) play an important role in many neurological diseases and can serve as biomarkers for these diseases. However, the information about circRNAs Parkinson disease (PD) remained limited. In this study, we aimed to determine expression profile PD patients discuss significance of diagnosis PD.Using RNA-sequencing peripheral blood RNAs, showed that a significant number mRNAs or were differentially expressed between normal controls (NCs), which included 273 up-regulated 493...
Copy-number variations (CNV), loss of heterozygosity (LOH), and uniparental disomy (UPD) are large genomic aberrations leading to many common inherited diseases, cancers, other complex diseases. An integrated tool identify these is essential in understanding diseases designing clinical interventions. Previous discovery methods based on whole-genome sequencing (WGS) require very high depth coverage the whole genome scale, cost-wise inefficient. Another approach, exome (WEGS), limited...
The skin is the largest organ in human body. Various environments on its surface constitutes a complex ecosystem. One of characteristics micro-ecosystem low biomass, which greatly limits comprehensive identification microbial species through sequencing. In this study, deep-shotgun sequencing (average 21.5 Gigabyte (Gb)) from 450 facial samples and publicly available metagenomic datasets 2069 to assemble Unified Human Skin Genome (UHSG) catalog integrated. UHSG encompasses 813 prokaryotic...
Abstract Comprehensive reference genomes are needed for the classification and functional characterization of human skin microbiota. Here, we established microbiome genome (HSMG) protein (HSMP) catalogs by integrating 739 newly sequenced 2,520 published samples, along with two microbial catalogs. The HSMG includes 3547 prokaryotic species, which 1556 (43.87%) unidentified, HSMP contains 39,283,339 nonredundant proteins, 64.8% poorly characterized. Using as a reference, identified distinct...
Introduction Human skin serves as a dynamic habitat for diverse microbiome, including complex array of viruses whose diversity and roles are not fully understood. Objectives This study aims to enhance our understanding this viral through the construction detailed, non-redundant DNA reference catalog. Methods A total 2,760 metagenomes from six published studies were collected. virome catalog was constructed using methods independent databases. Viral characteristics identified cross-cohort...
Small object detection remains a challenge in remote sensing field due to feature loss during downsampling and interference from complex backgrounds. A novel network, termed SEMA-YOLO, is proposed this paper as an enhanced YOLOv11-based framework incorporating three technical advancements. By fundamentally reducing information cross-scale fusion mechanism, the significantly enhances small performance. First, Shallow Layer Enhancement (SLE) strategy reduces backbone depth introduces...
Numerous studies have investigated the risk factors of Alzheimer's disease (AD); however, AD-risk related miRNAs were rarely reported. In this study, factor 105 Chinese individuals (45 AD patients and 60 cognitively normal controls) investigated. The results showed that Hsa-miR-185-5p, Hsa-miR-20a-5p, Hsa-miR-497-5p to education, Hsa-miR-181c-5p, Hsa-miR-664a-3p, Hsa-miR-27a-3p, Hsa-miR-451a, Hsa-miR-320a depression. Target prediction above these involved in generation clearance amyloid-beta...
Hepatocellular carcinoma (HCC) is the fourth main reason of cancer-related death. Codonopsis pilosula a commonly used traditional Chinese medicine (TCM) for patients with HCC. However, its potential mechanism treatment HCC remains unclear. Here, we transcriptomics and network pharmacology to explore molecular mechanisms pilosula. In our study, twelve differentially expressed genes (DEGs) (5 upregulated 7 downregulated) treating HepG2 cells (a kind cell) were identified. Among 12 DEGs, HMOX1...
Colorectal cancer (CRC) is the second leading cause of deaths and continuously increases new cases globally. Accumulating evidence links risks CRC to antibiotic use. Long-term use abuse antibiotics increase resistance gut microbiota; however, whether associated with in microbiota still unclear. In this study, we performed a de novo assembly metagenomic sequences 382 patients 387 healthy controls obtain representative species-level genome bins (rSGBs) plasmids analyzed abundance variation...
Abstract Research based on a strategy of single-cell low-coverage whole genome sequencing (SLWGS) has enabled better reproducibility and accuracy for detection copy number variations (CNVs). The amplification (WGA) method platform are critical factors successful SLWGS (<0.1 × coverage). In this study, we compared single cell multiple cells data produced by the HiSeq2000 Ion Proton platforms using two WGA kits then comprehensively evaluated GC-bias, reproducibility, uniformity CNV among...
Recent technological advances in multi-omics and bioinformatics provide an opportunity to develop precision health assessments, which require big data relevant bioinformatic methods. Here we collect from 4,277 individuals. We calculate the correlations between pairwise features cross-sectional then generate 11 biological functional modules (BFMs) males 12 BFMs females using a community detection algorithm. Using BFM associated with cardiometabolic health, carotid plaques can be predicted...
Two hundred and thirty‐six novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the China Marrow Donor Program: 71 HLA‐A alleles, 79 HLA‐B 43 HLA‐C, 16 HLA‐DRB1 26 HLA‐DQB1 1 HLA‐DPB1. thirteen (90.3%) 236 single nucleotide substitution variants when compared with their most homologous allele. Seventy‐eight these silent substitutions. The remaining differ similar allele by two to four Some encode amino acid changes at positions not previously reported be...
The article to which this Erratum refers was published in Human Mutation 34(12): 1715–1720 (10.1002/humu.22439). contained an error one author's name. It is corrected here. authors regret error.
We have developed a new method for non-invasive prenatal testing (NIPT) of paternally inherited fetal mutants β-thalassemia (β-thal). Specially designed primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR) were used to detect four major mutations [IVS-II-654, HBB: c.316-197C > T; codon 17 (A T), c.52A −28 G), c.-78A G and codons 41/42 (–TTCT), c.126_129delCTTT] causing β-thal in China. The PIRA-PCR assay was first tested series mixed DNA with different concentrations...
ABSTRACT Scope Antioxidants, including vitamin E (VE) and grape seed extract, as anti-aging supplementation have been widely used to improve human health. However, the role of gut microbiota in dietary antioxidant is debatable. This study aimed assess longitudinal impact with compounds on body health microbiota. Methods results One hundred twenty healthy individuals were randomly divided into a placebo group (amylodextrin) three experimental groups ingesting different supplement (VE, or...
<title>Abstract</title> <bold>Objective</bold>To assess the impact of early and late time-restricted eating (eTRE lTRE) on non-alcoholic fatty liver disease (NAFLD) its underlying mechanisms involving gut microbiota serum metabolome changes. <bold>Design</bold>This 8-week randomized clinical trial involved 40 NAFLD patients divided into eTRE (8:00 am to 4:00 pm) lTRE (12:00 pm 8:00 groups, with unrestricted caloric intake within these windows. Comprehensive analyses including nutrient...