A5033483734- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Traumatic Brain Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer-related cognitive impairment studies
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
Beijing Proteome Research Center
2023-2024
Jinan University
2024
Rutgers New Jersey Medical School
2012
Rutgers, The State University of New Jersey
2012
BGI Group (China)
2011
Abstract Radiation triage and biological dosimetry are critical for the medical management of massive potentially exposed individuals following radiological accidents. Here, we performed a genome-wide screening radiation-responding mRNAs, whose N6-methyladenosine (m 6 A) levels showed significant alteration after acute irradiation. The m A three genes, Ncoa4 , Ate1 Fgf22 in peripheral blood mononuclear cells (PBMCs) mice excellent dose-response relationships could serve as biomarkers...
Rationale: The level of miR-206-3p in the plasma and temporal cortex is increased Alzheimer's disease (AD) patients. antagomir injected into hippocampus ameliorates cognitive deficits by enhancing BDNF. However, trauma caused brain injection susceptibility to degradation limit its application. Methods: To overcome these challenges, we constructed engineered extracellular vesicles derived from mesenchymal stem cell (MSC-EVs) loaded with (MSC-EVs-anta) electroporation technology, explored...
Abstract Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown. By performing genome‐wide survey on prognosis‐associated focal CNAs in 814 HCC patients an integrative computational framework based transcriptomic data, genomic amplification identified at 8q24.13 as promising candidate. Further evidence provided that the amplification‐driven overexpression Rab GTPase activating...
Two hundred and thirty‐six novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the China Marrow Donor Program: 71 HLA‐A alleles, 79 HLA‐B 43 HLA‐C, 16 HLA‐DRB1 26 HLA‐DQB1 1 HLA‐DPB1. thirteen (90.3%) 236 single nucleotide substitution variants when compared with their most homologous allele. Seventy‐eight these silent substitutions. The remaining differ similar allele by two to four Some encode amino acid changes at positions not previously reported be...
Nine novel human leukocyte antigen‐DRB1 (HLA‐DRB1) alleles were identified in Chinese individuals.
Objective: To elucidate cellular and molecular changes associated with the exposure of neural stem cells (NSCs) to high low doses ionizing radiation. Background Damage normal human brain from targeted radiation may occur during course cancer radiotherapy or accidental exposure. Delayed effects complicate acute immediate effects, in particular have been neurodegeneration cognitive decline. These delayed arise slow death irradiated cells, damage that survive exposure, negative on cell...
Human single-stranded DNA-binding protein homologs hSSB1 (SOSSB1) and hSSB2 (SOSSB2) make a vital impact on maintaining genome stability as the B subunits of sensor DNA complex (SOSS). However, whether how SOSSB1 SOSSB2 modulate mutual expression is unclear. This study, demonstrated that depletion in cells enhances protein, conversely, protein. The levels proteins are mutually regulated through their competitive binding with SOSSA which associates highly conservative OB-fold domain SOSSB2....