A5087254207- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Crop Yield and Soil Fertility
- Plant Molecular Biology Research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Plant nutrient uptake and metabolism
- Genetic Associations and Epidemiology
- Hepatitis C virus research
- Immune cells in cancer
- Cellular transport and secretion
- AI in cancer detection
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- COVID-19 diagnosis using AI
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Genomic variations and chromosomal abnormalities
- Advanced Neural Network Applications
- Autophagy in Disease and Therapy
- Single-cell and spatial transcriptomics
Yangzhou University
2024-2025
Shandong Center for Disease Control and Prevention
2025
Beijing Proteome Research Center
2017-2024
State Key Laboratory of Proteomics
2020-2024
Tsinghua University
2018
National Institutes for Food and Drug Control
2017
Abstract Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and development. Here, we generate single-cell atlas multicellular ecosystem HCC from four tissue sites. We show enrichment central memory T cells (T CM ) in early tertiary lymphoid structures (E-TLSs) assess relationships chronic HBV/HCV infection cell infiltration exhaustion. find MMP9 + macrophages to be terminally differentiated tumor-associated (TAMs) PPARγ pivotal...
As two major types of primary liver cancers, the tumor immune microenvironment (TIME) hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have been well studied separately. However, a systemic assessment similarities differences between TIME HCC ICC is still lacking. In this study, we pictured landscape combined by sequencing integrating 41 single-cell RNA-seq samples from four different tissue both malignancies. We found that T cells in tumors generally exhibit higher...
Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chronic hepatitis B virus (HBV) infection remains major risk factor for HCC. this study, we performed a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci contributing susceptibility HBV-related HCC.Experimental Design: GWAS scan in collection 205 HCC trios (each trio includes an affected proband and his/her both parents), 355 HBV carriers with (cases) 360...
Hepatocellular carcinomas (HCCs) are characterized by frequent somatic genomic copy number alterations (CNAs), with most of them biologically unexplored. Here, we performed integrative analyses combining CNAs the transcriptomic data to reveal cis- and trans-effects in HCC. We identified recurrent gains chromosome 8q, which exhibit strong broadly associated ribosome biogenesis activity. Furthermore, 8q gain-driven overexpression regulator (RRS1) promotes growth HCC cells vitro vivo....
Lateral roots (LRs) branching is crucial for water and nutrient acquisition in plants, ultimately determining the overall plant performance productivity. However, transcriptional regulation of LR development crops its role stress resilience remain largely unexplored. Leveraging integrated transcriptome-wide association study single-cell RNA sequencing data, we identified a basic leucine zipper (bZIP) transcription factor ZmbZIP89 as an important regulator elongation mapped spatial expression...
PCBs were analysed in 110 samples, including marine fish, freshwater fish and bivalves. The levels of ∑7PCBs ranged from 0.18 to 5.59 ng g-1 wet weight (ww), 0.10 1.19 ww bivalves 0.07 ww. highest level was found Scomberomorus niphonius. In bivalves, the most abundant compounds Hexa-CBs, Tri-CBs respectively. distributed a species-specific manner aquatic products. None product samples exceeded limit for set by China or established European Union.
Abstract Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown. By performing genome‐wide survey on prognosis‐associated focal CNAs in 814 HCC patients an integrative computational framework based transcriptomic data, genomic amplification identified at 8q24.13 as promising candidate. Further evidence provided that the amplification‐driven overexpression Rab GTPase activating...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, relevant functional target(s) that locus not well determined. Here, we performed integrative genomic analyses and identified zinc finger CCCH-type containing 14 (ZC3H14) as a promising candidate 14q31.1-32.13. We frequent (17.1%) downregulation ZC3H14 primary HCC tissues. Downregulation significantly...
Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and development. Here, we generated single-cell atlas multicellular ecosystem HCCs from four relevant sites. Antitumor central memory T (TCM) cells were found in tertiary lymphoid structures (TLSs). Chronic HBV/HCV infection increases infiltration CD8+ tumors but aggravates cell exhaustion. We identified CD11b+ macrophages to be terminally differentiated tumor-associated (TAMs) two...
Root system architecture is pivotal for the acquisition of water and nutrients in maize, serving as an essential foundation achieving high stable yields. Identification genetic components natural variations determining root traits may facilitate molecular breeding maize varieties with better traits. Melatonin plays important role plant physiology development. In this study, nine melatonin biosynthesis genes were re-sequenced 348 inbred lines, 68 landraces, 32 teosintes to investigate related...
<div>Abstract<p><b>Purpose:</b> Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chronic hepatitis B virus (HBV) infection remains major risk factor for HCC. this study, we performed a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci contributing susceptibility HBV-related HCC.</p><p><b>Experimental Design:</b> GWAS scan in collection 205 HCC trios (each trio...
<div>Abstract<p><b>Purpose:</b> Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In China, chronic hepatitis B virus (HBV) infection remains major risk factor for HCC. this study, we performed a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci contributing susceptibility HBV-related HCC.</p><p><b>Experimental Design:</b> GWAS scan in collection 205 HCC trios (each trio...
Generating semantic segmentation datasets has consistently been laborious and time-consuming, particularly in the context of large models or specialized domains(i.e. Medical Imaging Remote Sensing). Specifically, necessitate a substantial volume data, while professional domains frequently require involvement domain experts. Both scenarios are susceptible to inaccurate data labeling, which can significantly affect ultimate performance trained model. This paper proposes simple effective label...