A5049859615- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Amyotrophic Lateral Sclerosis Research
- Catalytic C–H Functionalization Methods
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Synthesis and Biological Activity
- Synthesis of Indole Derivatives
- Circular RNAs in diseases
- Synthesis of Organic Compounds
- Genetic Neurodegenerative Diseases
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- RNA Research and Splicing
- Nonlinear Optical Materials Research
- Nerve injury and regeneration
- Kruppel-like factors research
- Magnetic confinement fusion research
- RNA regulation and disease
- Connexins and lens biology
Fudan University
2016-2025
Huainan Normal University
2024
Sun Yat-sen Memorial Hospital
2020-2024
Sun Yat-sen University
2020-2024
Huashan Hospital
2016-2021
Zhengzhou Fruit Research Institute
2021
Chinese Academy of Agricultural Sciences
2021
National Clinical Research
2018
Huazhong University of Science and Technology
2015-2017
Ministry of Education of the People's Republic of China
2016-2017
Background Inflammasomes, which mediate the activation of caspase-1 and maturation IL-1β IL-18, have been unambiguously verified to participate in many diseases, such as lung infectious diseases Alzheimer's disease, but relation between Parkinson's disease inflammasomes is poorly understood. Methods The expression, maturation, secretion neurons were measured. substantia nigra brain was tested acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine an α-synuclein transgenic mouse model. levels...
Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant type of dementia worldwide. It characterized by progressive irreversible decline cognitive functions. In addition to pathological beta-amyloid (Aβ) deposition, glial activation, neuronal injury in postmortem brains AD patients, increasing evidence suggests that often overlooked vascular dysfunction an important early event pathophysiology. Vascular endothelial growth factor (VEGF) plays critical...
Parkinson's disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life. The 39-item Questionnaire (PDQ-39) most widely used PD-specific quality-of-life questionnaire. short-form 8-item (PDQ-8) was found to produce results similar that PDQ-39 cross-culturally. However, there no evaluation PDQ-8 in mainland China. In this longitudinal study, 283 patients were recruited. PDQ-39, other scales administered. Patients attended clinic...
To investigate the differences in pattern of striatal (caudate and putamen) dopamine transporter (DAT) loss a multiple system atrophy (MSA) cohort, based on clinical variants parkinsonian subtype (MSA-P) cerebellar (MSA-C) via (11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (11 C-CFT) positron emission tomography (PET) imaging.One hundred six subjects (forty-one patients with probable MSA-P; forty MSA-C; twenty-five healthy controls) underwent 11 C-CFT PET. Subregional uptake bilateral...
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by dopaminergic neuron death and abnormal accumulation aggregation of α-synuclein (α-Syn) in substantia nigra (SN). Although α-Syn can solely promote accelerate progress PD, underlying molecular mechanisms remain unknown. Mounting evidence confirms that expression long non-coding RNA (lncRNA) plays an important role PD. Our previous study found exogenous induced downregulation lncRNA-T199678 SH-SY5Y...
Abstract The green peach aphid (GPA), Myzus persicae, is a polyphagous, sap-sucking and vector of many plant viruses. In peach, Prunus persica, three individual dominant GPA resistance loci have been genetically defined (Rm1–3), but knowledge the underlying genes limited. this study, we focused on Rm3 locus. Bulk segregant analysis (BSA) mapping in segregating progeny populations delimited to an interval spanning 160 kb containing 21 chromosome 1. RNA-seq data provided no evidence candidate...
Parkinson's disease (PD) is the second most common neurodegenerative disorder, but disease-modifying therapies focusing on core pathological changes are still unavailable. Rho-associated protein kinase (ROCK) has been suggested as a promising target for developing neuroprotective in PD.We aimed to explore promotion of α-synuclein (α-syn) clearance rat model.In model induced by unilateral injection adeno-associated virus serotype 9 (AAV9) expressing A53T α-syn (AAV9-A53T-α-syn) into right...
Alpha-synuclein (α-Syn) is widely distributed and involved in the regulation of nervous system. The phosphorylation α-Syn at serine 129 (p Ser129 α-Syn) known to be closely associated with α-Synucleinopathies, especially Parkinson's disease (PD). present study aimed explore accumulation its enteric system (ENS) patients without neurodegeneration. Patients who underwent colorectal surgery for either malignant or benign tumors that were not suitable endoscopic resection ( n = 19) recruited...
Depressive symptoms and sensory dysfunction, such as reduction in visual olfactory function, are common Parkinson's disease (PD). Previous studies have suggested that depressive associated with impairments potentially hyposmia several types of mood disorders. However, the relationship between dysfunction remains unclear PD. To examine association color vision function PD, authors conducted a cross-sectional study 159 patients were measured Beck Depression Inventory-II (BDI-II) 30-item...
Abstract Neutral beam injection (NBI) has been proven as a reliable heating and current drive method for fusion plasma. For the high-energy NBI system (particle energy > 150 keV) of large-scale devices, negative ion source neutral (NNBI) is inevitable, which can obtain an acceptable neutralization efficiency (> 55%). But NNBI very complex challengeable. To explore master key technology future reactor in China, test facility under development framework Comprehensive Research Facility...
Fluorinated polyurethaneimide (PUI) electro-optic waveguide polymer with polyurethane and polyimide chain segment structures was synthesized by stepwise polymerization using the amino ester oligomer pu imide pi as monomers. Since main structure of PUI had functionality both structures, it combines excellent thermal film-forming properties polyurethanes polyimides, well lower optical transmission loss in near-infrared wavelength band. The glass transition temperature (Tg) 182 °C, 5% heat...
A novel and efficient four-component dicyclization strategy has been developed for one-step constructing diverse antibacterial 3-(1,3,4-oxadiazol-2-yl)isoindolin-1-ones under very mild base-free metal-free conditions without other additives. This one-pot process underwent two consecutive cyclization reactions including tandem Ugi/aza-Wittig reaction N-acylation by utilizing (N-isocyanimine)triphenylphosphorane, methyl 2-formylbenzoate, primary amines, carboxylic acids. The method was...
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A novel metal-free synthesis of 3-substituted isocoumarins through a sequential O-acylation/Wittig reaction has been established. The readily accessible (2-carboxybenzyl)-triphenylphosphonium bromide and diverse chlorides produced various 1H-isochromen-1-one in the presence triethylamine, employing O-acylation an intramolecular Wittig acid anhydride. Reactions using these facile conditions have exhibited high functional group tolerance excellent yields (up to 90%). Moreover, fluorescence...
A novel axially chiral all-hydrocarbon cyclo[7] (1,3-(4,6-dimethyl)benzene (