A5100347255- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- EEG and Brain-Computer Interfaces
- Nuclear Receptors and Signaling
- Epilepsy research and treatment
- Balance, Gait, and Falls Prevention
- Neurological disorders and treatments
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Amyotrophic Lateral Sclerosis Research
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Non-Invasive Vital Sign Monitoring
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Ginkgo biloba and Cashew Applications
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
Dalian Medical University
2019-2025
First Affiliated Hospital of Dalian Medical University
2020-2025
Yanshan University
2022-2025
Space Engineering University
2024
University of Twente
2021-2024
Affiliated Hospital of Qingdao University
2017-2024
Indiana University School of Medicine
2021-2024
Liaoning University of Traditional Chinese Medicine
2024
Indiana University – Purdue University Indianapolis
2021-2024
Ruijin Hospital
2015-2024
Loss of function mutations Park7/DJ-1 gene increase the susceptibility dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD). However, mechanisms underlying neuron loss related DJ-1 mutation remain undefined. Therefore, it is important find new antioxidative functions DJ-1.DJ-1 knockdown knockout mice were used elucidate stress DJ-1. Preliminary study saliva from PD patients controls was confirm our findings obtained above studies.Our experiments...
The misfolding and pathological aggregation of α-synuclein forming insoluble amyloid deposits is associated with Parkinson's disease, the second most common neurodegenerative disease in world population. Characterizing self-assembly mechanism critical for discovering treatments against synucleinopathies. intrinsically disordered property, high degrees freedom, macroscopic timescales conformational conversion make its characterization extremely challenging vitro silico. Here, we...
The purposes of this study were three-fold: (i) to determine the contribution known genes causation a broad-spectrum pediatric drug-resistant epilepsy (DRE), (ii) compare diagnostic yield and cost among different next-generation sequencing (NGS) approaches, especially (iii) assess how NGS approaches can benefit patients by improving diagnosis treatment efficiency.This enrolled 273 DRE with no obvious acquired etiology. Seventy-four underwent whole-exome (WES), 141 had epilepsy-related gene...
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (SN) region. Acteoside has displayed multiple biological functions. Its potential role against PD and underlying signaling mechanisms are largely unknown. Here, we showed that oral administration acteoside significantly attenuated parkinsonism symptoms rotenone-induced rats. Further, inhibited α-synuclein, caspase-3 upregulation microtubule-associated protein 2 (MAP2)...
Abstract BACKGROUND Central blood pressure (CBP) independently predicts cardiovascular risk, but calibration methods may affect accuracy of central systolic (CSBP). Standard (Stan-CSBP) from peripheral waveforms is usually derived with using brachial SBP and diastolic BP (DBP). However, oscillometric mean arterial (MAP) DBP (MAP-CSBP) purported to provide more accurate representation true invasive CSBP. This study sought determine which CSBP could accurately discriminate cardiac structural...
How memories are organized in the brain influences whether they remembered discretely versus linked with other experiences or generalized information is applied to entirely novel situations. Here, we used scFLARE2 (single-chain fast light- and activity-regulated expression 2), a temporally precise tagging system, manipulate mouse lateral amygdala neurons active during one of two 3 min threat occurring close (3 h) further apart (27 time. Silencing scFLARE2-tagged showed that at distal times...
Abstract Background Freezing of gait (FOG) is an unpredictable arrest that hampers the lives 40% people with Parkinson’s disease. Because symptom heterogeneous in phenotypical presentation (it can present as trembling/shuffling, or akinesia) and manifests during various circumstances be triggered by e.g. turning, passing doors, dual-tasking), it particularly difficult to detect motion sensors. The freezing index (FI) one most frequently used accelerometer-based methods for FOG detection....
This study examined the effects of a multicomponent intervention program on cognitive function in community-dwelling older adults with mild impairment (MCI) and subjective decline (SCD).
Abstract Introduction Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease ( PD ). The aim our study was investigate cognitive performance motor dysfunction in Chinese patients with . Methods Data from 96 were obtained patient cohort database Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation assess status, that included scoring on Mini‐mental...
Curcumin (CUR) has the ability to attenuate oxidative stress in myocardium and protect from lipotoxic injury owing its lipid‑reducing properties. However, use of CUR is limited due hydrophobicity instability. In this study, CUR‑loaded nanoparticles (CUR NPs) were developed using an amphiphilic copolymer, monomethoxy poly (ethylene glycol)‑b‑poly (DL‑lactide), as a vehicle material. NPs with high drug loading small size prepared under optimized conditions. The effects on palmitate‑induced...
Purpose To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET). Methods Three groups of patients were recruited this study including PD dementia (PDD; n = 10), mild impairment (PD-MCI; 20), no (PD-NC; 30). The matched for age, sex, education, duration, motor disability, levodopa equivalent dose Geriatric Depression Rating Scale (GDS) score. All subjects...
We investigated economic costs from patients with Parkinson's disease (PD) in Shanghai, China, which could be used as a baseline for future evaluations. Data were collected 190 by interview during 1-year period. Direct medical care averaged approximately Chinese yuan, renminbi (RMB) 4,305 (USD 519, or EUR 410) per year patient, of drugs (RMB 2,677) accounted the major costly component. Nonmedical direct much less than health costs, averaging RMB 3,301 398, 314). Costs due to loss...
ABSTRACT Background Genome‐wide association studies (GWAS) have identified numerous single‐nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD). Methods We investigated previously loci in a Mainland Chinese population to identify possible ethnic‐specific effect with GWAS analysis. Seventeen SNPs were genotyped from those using case–control methodology analyze total 1,737 individuals. Results Strong evidence an for reference SNP 894278 (rs894278)...
Parkinson's disease is characterized by motor and non-motor symptoms with wide ranging impacts on the health-related quality of life. The 39-item Questionnaire (PDQ-39) most widely used PD-specific quality-of-life questionnaire. short-form 8-item (PDQ-8) was found to produce results similar that PDQ-39 cross-culturally. However, there no evaluation PDQ-8 in mainland China. In this longitudinal study, 283 patients were recruited. PDQ-39, other scales administered. Patients attended clinic...