A5100398418- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Glioma Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Allergic Rhinitis and Sensitization
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Aortic aneurysm repair treatments
- RNA Research and Splicing
- Cardiac and Coronary Surgery Techniques
- Viral-associated cancers and disorders
- Neuroendocrine Tumor Research Advances
- Asian Culture and Media Studies
- Cancer Research and Treatments
- Cardiac electrophysiology and arrhythmias
Southern Medical University
2022-2025
Dongguan People’s Hospital
2023-2025
Texas Children's Hospital
2024
Baylor College of Medicine
2024
Children's Cancer Center
2024
Hainan Medical University
2021-2024
Wuhu Fourth People Hospital
2024
East China Normal University
2024
Wannan Medical College
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2018-2023
The benefit of neoadjuvant camrelizumab plus chemotherapy for resectable stage IIIA or IIIB non-small cell lung cancer (NSCLC) remains unknown.To assess the efficacy and safety vs alone patients with NSCLC.In this randomized phase 2 clinical trial conducted at hospitals in China, aged 18 to 70 years (T3N2) NSCLC were enrolled between April 7, 2020, January 12, 2022.Patients randomly assigned receive 3 cycles (200 mg) (nab-paclitaxel, 130 mg/m2, platinum [cisplatin, 75 mg/m2; carboplatin,...
<h3>Importance</h3> Most older patients with esophageal cancer cannot complete the standard concurrent chemoradiotherapy (CCRT). An effective and tolerable regimen for is needed. <h3>Objective</h3> To evaluate efficacy toxic effects of CCRT S-1 vs radiotherapy (RT) alone in cancer. <h3>Design, Setting, Participants</h3> A randomized, open-label, phase 3 clinical trial was conducted at 23 Chinese centers between June 1, 2016, August 31, 2018. The study enrolled 298 aged 70 to 85 years....
Abstract Purpose: In this multicenter phase 3 trial, the efficacy and safety of 60 Gy 50 doses delivered with modern radiotherapy technology for definitive concurrent chemoradiotherapy (CCRT) in patients inoperable esophageal squamous cell carcinoma (ESCC) were evaluated. Patients Methods: pathologically confirmed stage IIA‒IVA ESCC randomized 1:1 to receive conventional fractionated or tumor regional lymph nodes. Concurrent weekly chemotherapy (docetaxel 25 mg/m2; cisplatin mg/m2) two...
Abstract Background Neoadjuvant programmed death receptor-1 (PD-1) inhibitors have drawn increasing attention in locally advanced head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the safety efficacy of gemcitabine cisplatin (GP), combined with a PD-1 inhibitor, patients HNSCC. Materials methods A total 23 eligible were administered two cycles toripalimab GP followed by surgical resection. The primary endpoints safety, treatment-related adverse events (TRAEs),...
Objective: To determine the prophylactic efficacy of short-term intensive preoperative inspiratory muscle training on incidence postoperative pulmonary complications in patients scheduled for cardiac surgery. Design: Single-blind, randomized controlled pilot study. Setting: TEDA International Cardiovascular Hospital, China. Subjects: In total, 197 subjects aged ⩾50 years surgery were selected. Intervention: The intervention group ( n = 98) received five days top usual care by control 99)....
Abstract Introduction Atrial fibrillation (AF) ablation requires access to the left atrium (LA) via transseptal puncture (TP). TP is traditionally performed with fluoroscopic guidance. Use of intracardiac echocardiography (ICE) and three‐dimensional mapping allows for zero fluoroscopy TP. Objective To demonstrate safety efficacy using multiple procedural approaches. Methods Patients undergoing AF between January 2015 November 2017 at five institutions were included. ICE used sheath...
To better understand the Ca2+ overload mechanism of SDT killing gliomas, we examined hypothesis that early application mechanosensitive channel Piezo1 antagonist (GsMTx4) could have a anti-tumor effect.The in vitro effect low-energy combined with GsMTx4 or agonist Yoda 1 on both ROS-induced distribution as well opening and dissociation polymerization lipid complex were assessed. The same groups also studied to determine their effects tumor-bearing BALB/c-nude C57BL/6 intracranial tumors,...
Introduction Previous studies have reported a close relationship between cancer and microbes, particularly gut tumor microbiota; however, the presence of microbiome in nasopharyngeal carcinoma (NPC) its role prognosis NPC remain unclear. Methods We collected 64 samples including tissues from 50 patients with (NPC group) 14 chronic nasopharyngitis (control receiver operating characteristics we applied 16S ribosome RNA gene sequencing all to assess profiles immunohistochemistry detect NPC....
ABSTRACT Midnolin (MIDN) is a protein coding gene that promotes the destruction of transcription factors encoded by immediate‐early genes. Previous research has found those genes are involved in tumour progression. However, role MIDN still not clearly identified human cancers. With help TCGA, GTEx, and HPA databases, we revealed expression was disordered potential prognostic biomarker liver cancer bladder cancer. Prognostic analysis indicates level gains survival benefits or progression...
Abstract Radiotherapy-induced oral mucositis (RTOM) is a common side effect of radiotherapy in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (CCRT). In this phase 3 trial, we aim to evaluate the efficacy and safety Ulinastatin (UTI) for prevention treatment RTOM LA-NPC patients (NCT03387774). The primary endpoint incidence grade ≥3 acute during radiotherapy. Secondary endpoints include cumulative RTOM, recovery rate, onset time duration pain...
Although pathological complete response (pCR) and major (MPR) rates of neoadjuvant immunotherapy combined with chemotherapy in head neck squamous cell carcinoma (HNSCC) trials remain suboptimal, emerging evidence highlights the synergistic potential combining low-dose radiotherapy to promote efficacy immunotherapy. This phase II, open-label, single-arm, multicenter trial (NCT05343325) enrolled 28 patients untreated stage III-IVB HNSCC (NeoRTPC02). Patients received radiotherapy, programmed...
Background: Despite multimodality therapies, the prognosis of patients with malignant brain tumors remains extremely poor. One major obstacles that hinders development effective therapies is limited availability clinically relevant and biologically accurate (CRBA) mouse models. Methods: We have developed a freehand surgical technique allows for rapid safe injection fresh human tumor specimens directly into matching locations (cerebrum, cerebellum, or brainstem) in brains SCID mice. Results:...
Abstract Background Oral squamous cell carcinoma (OSCC) has been one of the most malignant cancers in head and neck region. Anlotinib is a tyrosine kinase inhibitor targeting several receptors such as vascular endothelial growth factor receptor (VEGFR), fibroblast (FGFR), platelet-derived (PDGFR) c-Kit. Here we investigated whether have any antitumor effect on oral cancer tried to explore explain possible mechanism. Methods Data from The Cancer Genome Atlas Gene Expression Omnibus database...
Metabolic reprogramming is a novel method for the treatment of malignant tumors. The exploration metabolism procedures between radiosensitive and radioresistant tumors may provide perspectives lung adenocarcinoma (LUAD) patients after radiation therapy. In our study, metabolic immune response changes were found cell line (A549RR) its parent cells (A549) using gene ontology Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis. Nucleotide/amino acid, lipid, glucose process, including...
ZnO nanocrystalline films are prepared on Si substrates at different temperatures by using metal-organic chemical vapour deposition (MOCVD). It is observed that when the growth temperature low, stoichiometric ratio between Zn and O atoms has a large deviation from ideal of 1:1. The grains in film have small sizes not well crystallized, resulting poor photoluminescence (PL) property. When increased to an appropriate value, Zn/O becomes optimized, most combined into Zn—O bonds. Then good...
Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR) C667T and A1298C reduced folate carrier 1 RFC-1) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) efficacy toxicity methotrexate (MTX) treatment in Chinese Han patients Henan, China. Methods Two hundred ninety-six RA were enrolled (cases) 120 healthy individuals served as controls. genotypes MTHFR SNP RFC-1 detected by restriction fragment length polymorphism-PCR...
The aim of the present study was to develop a metastatic risk score model neck level Ib lymph nodes in primary nasopharyngeal carcinoma (NPC) guide radiotherapy. There were total 1,557 patients enrolled study, and these patients, 1,145 included training set. Univariate χ2 analysis multivariate logistic regression analyses used screen independent factors construct model. A 85 validating set underwent pathology biopsy test remaining 327 from prognostic-research evaluate prognostic impact...