A5101966924- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Parkinson's Disease Mechanisms and Treatments
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Neurological disorders and treatments
- Chronic Lymphocytic Leukemia Research
- Nuclear Receptors and Signaling
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Integrated Circuits and Semiconductor Failure Analysis
- Hepatitis C virus research
- Advancements in Semiconductor Devices and Circuit Design
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- RNA regulation and disease
- Catalysis and Oxidation Reactions
- Microbial Natural Products and Biosynthesis
- Vascular Tumors and Angiosarcomas
- Genetics and Neurodevelopmental Disorders
- Catalytic Processes in Materials Science
- Autism Spectrum Disorder Research
- Fungal Biology and Applications
Peking University
2016-2025
Capital Medical University
2023-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Wenzhou Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2024-2025
Beijing Anzhen Hospital
2023-2025
Peking University Cancer Hospital
2015-2024
Shandong University
2018-2024
Soochow University
2024
Shandong Provincial Hospital
2024
Significance Although error rates in protein translation, particularly under stress, are high, it is not known if these errors inherent to the system, or they may have an adaptive function. Here, we provide evidence that specific mistranslation of mycobacterial proteins important for phenotypic resistance antibiotic rifampicin. This raises possibility translation play a role adapting stress through increasing proteomic diversity.
CD19-targeted chimeric antigen receptor-T (CAR-T) cells with CD28 or 4-1BB (28z CAR-T and BBz CAR-T) have shown great promise to treat relapsed refractory (r/r) B cell non-Hodgkin's lymphoma (B-NHL). However, comparison of their clinical outcomes has never been reported. This study investigated efficacy adverse events in B-NHL therapy. Six patients r/r were initially enrolled infused 28z at a dose 0.75-5 × 105/kg. These showed similar antitumor efficacies, complete response (CR) rate 67%...
// Wenjie Qin 1, 2, * , Chao Li Wen Zheng Qingqu Guo 2 Yuefeng Zhang Muxing Kang Bo Bin Yang Baozhong 3 Haijun 4 Yulian Wu 1 Department of Surgery, Second Affiliated Hospital, Zhejiang University School Medicine, Hangzhou, P. R. China Key Laboratory Cancer Prevention and Intervention, National Ministry Education, Institute, Zhejiang, Oncosurgery, Anyang Tumor Henan, Pathology, These authors have contributed equally to this work Correspondence to: Wu, e-mail: wuyulian@medmail.com.cn Keywords:...
<h3>Importance</h3> Most older patients with esophageal cancer cannot complete the standard concurrent chemoradiotherapy (CCRT). An effective and tolerable regimen for is needed. <h3>Objective</h3> To evaluate efficacy toxic effects of CCRT S-1 vs radiotherapy (RT) alone in cancer. <h3>Design, Setting, Participants</h3> A randomized, open-label, phase 3 clinical trial was conducted at 23 Chinese centers between June 1, 2016, August 31, 2018. The study enrolled 298 aged 70 to 85 years....
Epilepsy is a group of enduring neurological disorder characterized by spontaneous and recurrent seizures with heterogeneous etiology, clinical expression, severity, prognosis. Growing body research investigates that epileptic are originated from neuronal synchronized excessive electrical activity. However, the underlying molecular mechanisms epileptogenesis have not yet been fully elucidated 30% patients still resistant to currently available pharmacological treatments throughout life. Over...
Diiron dithiolate complexes have received special attention because of their structural similarity to the active site [FeFe]-hydrogenases, which are most efficient and fastest catalysts for generation dihydrogen in nature. Recently, we established a novel way prepare phosphine-substituted diiron aza- oxadithiolate complexes. Reaction Fe2(μ-SCH2OH)2(CO)6 several phosphine ligands L (L = PPh3, PPh2(2-C5H4N), P(C6H4-4-CH3)3) affords intermediate Fe2(μ-SCH2OH)2(CO)5L, while situ reacts with...
// Lijuan Deng 1 , Yuqin Song Ken H. Young 2 Shimin Hu Ning Ding Weiwei Xianghong Li 3 Yunfei Shi Huiying Huang Weiping Liu Wen Zheng Xiaopei Wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Zhitao Ying Chen Zhang Yingli Sun Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Lymphoma Unit, Peking University Cancer Hospital & Institute, Beijing, China Department Hematopathology, The Texas MD Anderson Center, Houston, TX, USA Pathology, Correspondence...
Abstract Background The treatment outcomes and prognosis of lymphoma are affected by various factors such as hospital types. This study was to describe the temporal trend in survival an academic center China. Methods A total 3840 consecutive patients with diagnosed between 1996 2015 were reviewed. Eighty excluded, finally, 3760 analyzed this study. cohort divided into four groups according calendar periods at diagnosis: 1996‐2000, 2001‐2005, 2006‐2010, 2010‐2015. overall (OS) rates among...
To explore the efficacy and safety of L-asparaginase in newly-diagnosed extranodal nature killer (NK)/T -cell lymphoma (ENKTL), we conducted a prospective phase II study L-asparaginase, cyclophosphamide, vincristine, doxorubicin dexamethasone (CHOP-L) regimen combination with radiotherapy.Patients newly diagnosed ENKTL an ECOG performance status 0 to 2 were eligible for enrollment. Treatment included 6-8 cycles CHOP-L (cyclophosphamide, 750 mg/m(2) day 1; 1.4 1 (maximal dose mg), 50 10 mg...
Abstract Dual-specificity phosphatase 6 (DUSP6) serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). We previously identified Dusp6 as regenerative repressor during zebrafish heart regeneration, therefore we propose to investigate role this in mammalian cardiac repair. Utilizing rat strain harboring nonsense mutation, neutrophil-cardiomyocyte co-culture, bone marrow transplanted rats neutrophil-specific knockout mice, find...
The exact incidence and severity of hepatitis B virus (HBV) reactivation after the withdrawal prophylactic antiviral therapy (delayed HBV reactivation) is unknown. We retrospectively analyzed 107 newly diagnosed diffuse large cell lymphoma patients with infection who received chemotherapy. median time from cessation antitumor to was 6.1 months. delayed 21.7% in HBsAg-positive group 0 HBsAg-negative/anti-HBc-positive (P < 0.001). No HBV-related fulminant or hepatitis-related death occurred....
Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown protect heart from aldehyde toxicity such as 4-hydroxy-2-nonenal (4-HNE) and oxidative stress. In this study, we evaluated effect enhanced activity or expression ALDH2 on post-cardiac survival in a rat cardiac model. Furthermore, elucidated underlying...
Abstract Background Classical Hodgkin lymphoma (cHL) is a highly curable disease, while novel therapy needed for refractory or relapsed (R/R) patients. This phase II trial aimed to evaluate the role of camrelizumab plus gemcitabine and oxaliplatin (GEMOX) in R/R cHL Methods Transplant-eligible patients with were enrolled received two 14-day cycles 200 mg intravenously (IV) 28-day IV, 1000 mg/m 2 100 IV on days 1 15. Patients partial response (PR) stable disease an additional cycle...
As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediated ubiquitination-dependent degradation IR (insulin receptor) IRS1 receptor substrate 1) myokine function-induced allosteric blockage IR. Here, we sought to develop into a therapy separating detrimental metabolic effects from beneficial...
A skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines chronic kidney disease (CKD) in individuals dysfunction-associated steatotic liver (MASLD) uncertain. This study examined the associations between and risk of CKD MASLD population. We performed a large-scale four cohorts: PERSONS NHANES 2011-2014 cohorts for cross-sectional investigation, TCLSIH UK Biobank longitudinal investigation. handgrip dynamometer measured as proxy overall...
Aim: Parkinson’s disease (PD) is the second most common progressive neurodegenerative linked to genetic and other factors. The NUS1 dehydrodolichyl diphosphate synthase subunit gene (NUS1) variants were reported be associated with PD. In this PD-control cohort, we aimed explore potential role of in Methods: A cohort 512 Han Chinese sporadic PD patients 516 ethnically age-matched controls underwent clinical evaluation. Peripheral blood samples then collected, whole-exome sequencing was...
The relationship between glycated hemoglobin (HbA1c) and cognitive impairment in older adults with coronary heart disease (CHD) remains unclear. present study used a prospective cohort design included 3244 participants aged ≥ 65 years Beijing, China. Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) were to assess function. Serum HbA1c was detected at admission. All patients divided into high group (≥ 6.5 mmol/L) low (< based on their levels. Logistic regression...
BACKGROUND: Myocardial ischemia/reperfusion (I/R) injury is a substantial challenge to the management of ischemic heart disease, leading cause mortality worldwide. Arachidonic acid (AA) prominent polyunsaturated fatty in human body and plays an important role various physiological pathological conditions. AA metabolic enzymes determine levels; however, currently there no comprehensive analysis cardiac I/R injury. METHODS: The profiling was analyzed with RNA sequencing transcriptome data from...