A5088126310- interferon and immune responses
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Peptidase Inhibition and Analysis
- Biosensors and Analytical Detection
- Natural product bioactivities and synthesis
- Cancer Research and Treatments
- Virus-based gene therapy research
- Glaucoma and retinal disorders
- Head and Neck Surgical Oncology
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Diet and metabolism studies
- Bioactive Natural Diterpenoids Research
- Phytochemical compounds biological activities
- Advanced Glycation End Products research
Sun Yat-sen University
2023-2025
Sun Yat-sen University Cancer Center
2023-2025
First Affiliated Hospital of Anhui Medical University
2018-2025
Sichuan Animal Science Academy
2025
Anhui Medical University
2018-2025
Chongqing Medical University
2024
Hebei University
2024
State Key Laboratory of Oncology in South China
2024
Qiqihar Medical University
2021-2024
Second Affiliated Hospital of Guangzhou Medical University
2020-2024
Peptide-functionalized gold nanoparticles (AuNPs) are extensively utilized in colorimetric assays for rapid and sensitive detection of various biomedical environmental targets. Although used as reporting systems, the role size concentration AuNPs has not been thoroughly investigated. In this study, a 12-mer cardiac troponin I (cTnI)-specific peptide CALNN-Peg4-FYSHSFHENWPS was immobilized on different via CALNN anchoring sequence. A relationship established between total surface area...
Abstract Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused cell apoptosis, and research ferroptosis-inducing effect has rarely been reported. Herein, we first discovered excellent cytotoxicity towards human nasopharyngeal carcinoma cells elucidated its potential mechanisms. Morphology alterations mitochondrial ultrastructure, as observed via transmission...
Ultrasensitive and accurate detection of biomarkers in serum is great importance for disease diagnosis treatment. So far, the commonly used single-mode signal suffers from certain instinct drawbacks that restrict assay performances. Herein, we report proof-of-concept fabrication a split-type photoelectrochemical (PEC) electrochemical (EC) dual-modal aptasensor ultrasensitively tracing tumor necrosis factor-α, noteworthy biological biomarker with essential clinical importance. By smart...
Botulinum neurotoxin is considered as one of the most toxic food-borne substances and a potential bioweapon accessible to terrorists. The development an accurate, convenient, rapid assay for botulinum neurotoxins therefore highly desirable addressing biosafety concerns. Herein, novel biotinylated peptide substrates designed mimic synaptosomal-associated protein 25 (SNAP-25) are utilized in gold nanoparticle-based assays colorimetric detection serotype A light chain (BoLcA). In these...
Autophagy resembles a recycling process in which proteins, organelles, or regions of the cytoplasm are enveloped and degraded. We have found that two central autophagy MAP1LC3 (microtubule-associated protein 1 light chain 3, also described as LC3) UVRAG (UV radiation resistance associated/UV associated gene), complex with PGRMC1/S2R (progesterone receptor membrane component 1, known sigma-2 receptor). PGRMC1 is cytochrome induced cancer essential for tumor formation, invasion, metastasis....
Synovial macrophage polarization is essential for osteoarthritis (OA) development. Our study aims to investigate the underlying function and molecular mechanisms of hsa_circ_0005567 in polarization. Circular RNA (CircRNA), microRNA (miRNA), mRNA expression levels were detected by quantitative reverse transcription polymerase chain reaction (RT-qPCR). pull down, luciferase reporter employed test interaction between miR-492 hsa_circ_0005567/suppressors cytokine signaling 2 (SOCS2). Ectopic...
Ultrasensitive and accurate monitoring of ultralow-level biomarkers is imperiously needed in clinical diagnosis. So far, exploring high-performance photocathodes developing new sensing strategies have remained central challenges photoelectrochemical bioassays. Herein, a two-dimensional (2D) pyrene covalent organic framework (COF, PAF-130) exemplified for the first time as photocathode precise immunosensing α-synuclein (α-Syn) by integrating DNAzyme-induced signal cycle amplification strategy...
Abstract Background Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease gut microbiome. However, different profiling patterns metabolic samples in make it a matter concern which type sample is most closely associated with microbes disease. To address this lack knowledge, we investigated microbiome metabolomic profiles stool, urine, plasma from ischemic stroke patients healthy subjects. Methods We performed...
To study the inhibiting effect of Endostar combined with ginsenoside Rg3 on breast cancer tumor growth in tumor-bearing mice.Female mice were selected as experimental animals, and mouse models established then divided into groups A, B, C D that respectively received saline, recombinant human endostatin, ginsenosides endostatin intervention; 7 d, 14 d 21 after intervention, tissue volume was measured; killed, collected, mRNA contents angiogenesis molecules, invasion autophagy marker molecules...
Excessive chondrocyte apoptosis is mostly responsible for the progression of osteoarthritis (OA). It has been shown that circular RNAs (circRNAs) are differentially expressed in OA cartilage and participate various pathological processes during OA. Here, this study was designed to explore effect molecular mechanism hsa_circ_0005567 on IL-1β-induced apoptosis. The results showed knockdown aggravated In contrast, overexpression attenuated apoptosis, but could be abrogated by 3-methyladenine...
Testes are crucial for male reproduction, and transcriptomic metabolomic analyses can help identify genes pathways linked to reproductive performance differences in pig breeds. The present study was conducted the differentially expressed accumulated metabolites (DAMs) through of testicular tissues Chuanxiang Black Landrace pigs. Six testis tissue samples from each breed were used analysis. Further liquid chromatography-mass spectrometry analysis performed targeted differential both...
ABSTRACT Midnolin (MIDN) is a protein coding gene that promotes the destruction of transcription factors encoded by immediate‐early genes. Previous research has found those genes are involved in tumour progression. However, role MIDN still not clearly identified human cancers. With help TCGA, GTEx, and HPA databases, we revealed expression was disordered potential prognostic biomarker liver cancer bladder cancer. Prognostic analysis indicates level gains survival benefits or progression...
Human induced pluripotent stem cell (hiPSC)-derived mesenchymal cells (iMSCs) are ideal candidates for the production of standardised and scalable bioengineered bone grafts. However, stable induction osteogenic differentiation iMSCs pose challenges in industry. We developed a precise method to produce homogeneous fully differentiated iMSCs. In this study, we established system prepare with increased potential improved bioactivity by introducing CHIR99021 (C91)-treated microenvironment...
Liver injury is a major hindrance to the treatment of tuberculosis (TB) patients due primary side effects associated with anti‑TB drugs. Several investigations have identified sensitive biomarkers for early diagnosis anti-TB drug-induced liver (ADLI), including use microRNAs (miRNAs/miRs). However, association between miR‑122/155 and ADLI remains unknown. Thus, present study used reverse transcription‑quantitative polymerase chain reaction observe changes in tissue expression levels during...