A5101603802- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Optic Conditions
- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Patient Satisfaction in Healthcare
- Global Maternal and Child Health
- Wound Healing and Treatments
- Sirtuins and Resveratrol in Medicine
Sun Yat-sen University
2016-2025
South China University of Technology
2025
Nanjing Normal University
2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Second Affiliated Hospital of Zhejiang University
2018-2024
Renji Hospital
2024
Hubei Water Resources Research Institute
2024
University Medical Centre Mannheim
2023
Heidelberg University
2023
Abstract Background To evaluate the peripapillary choroidal thickness of a healthy Chinese population, and to determine its influencing factors. Methods A total 76 volunteers (76 eyes) without ophthalmic or systemic symptoms were enrolled. Choroidal scans (360-degree 3.4 mm diameter circle scans) obtained for all eyes using enhanced depth imaging spectral-domain optical coherence tomography. Choroid was measured at temporal, superotemporal, superior, superonasal, nasal, inferonasal,...
Purpose.: To measure levels of various inflammation-related cytokines in the aqueous humor patients with acute primary angle-closure (APAC) and senile cataract. Methods.: Aqueous samples were prospectively collected from 23 eyes (12 current APAC 11 previous APAC) 15 cataract patients. The subjects measured by using multiplex bead immunoassay technique. Data on patient demographics preoperative intraocular pressure (IOP) also for correlation analysis. Results.: Compared group group, showed...
We evaluated choroidal thickness in the fellow eyes of patients with acute primary angle-closure (APAC) and compared findings to those normal controls.The study group comprised 44 defined as suspect (PACS) subjects who had experienced APAC 43 healthy volunteers. Using enhanced depth imaging optical coherence tomography (EDI-OCT), peripapillary macular PACS control were measured at each location or segment. Pearson correlation analysis a multivariable regression model used evaluate...
We compared the choroidal thickness of eyes patients with acute primary angle-closure (APAC) fellow in same patients.The analysis included 21 participants unilateral APAC affected and a diagnosis suspect (PACS). Enhanced depth imaging-optical coherence tomography (EDI-OCT) was used to measure macular peripapillary retinal both eyes. The average at each location or segment that eyes.At all locations, greatest subfovea for groups. Comparison between groups showed significantly greater than...
Purpose: To explore the microRNA (miRNA) profile and its putative role in glaucomatous optic neuropathy by using next-generation sequencing. Methods: Aqueous humor (AH) samples were collected from 19 primary open-angle glaucoma (POAG) eyes 17 cataract before surgery. Next-generation sequencing was performed for RNA extracted 18 AH samples, bioinformatics approach applied with adequate clean data output. The other used quantitative PCR validation of results. Results: In total, 12 (six POAG...
In the present study, we aimed to evaluate early postoperative rotational stability of TECNIS toric intraocular lens (IOL) and analyse its correlation with preoperative intraoperative parameters. A total 102 eyes from 87 cataract patients who underwent implantation IOL during July 2016 November 2017 were enrolled in this retrospective study. Preoperative parameters including corneal astigmatism, axial length (AL), thickness (LT), anterior chamber depth (ACD) sulcus-to-sulcus (STS),...
Clear cell renal carcinoma (ccRCC) is the most common subtype of carcinomas, with high mortality and poor prognoses worldwide. Succinate dehydrogenase (SDH) consists four nuclear-encoded subunits it only complex involved in both tricarboxylic acid (TCA) cycle oxidative phosphorylation (OXPHOS). Previous studies have shown decreased SDH activity ccRCC. However, role underlying molecular mechanisms ccRCC initiation development remain unclear. In present study, pan-cancer analysis gene...
Purpose: To describe the optic nerve head (ONH) abnormalities in nonpathologic highly myopic eyes based on swept-source optical coherence tomography (OCT) and relationship with visual field (VF). Design: Secondary analysis from a longitudinal cohort study. Methods: Highly patients without maculopathy of category 2 or higher were enrolled. All participants underwent OCT examination focused ONH. We differentiated between 3 major types (optic disc morphologic abnormality,...
Purpose.: To evaluate choroidal thickness (CT) in the subtypes of angle-closure (AC) disease compared with CT a healthy control. Methods.: A total 297 subjects (eyes) were enrolled study: 87 nonglaucoma controls and 210 AC subtype eyes (primary suspect [PACS], 73 eyes; acute primary [APAC], 46 [PAC], 35 glaucoma [PACG], 56 eyes). Enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) was used to measure macular control subjects. The average among five groups. Results.:...
Objective To review the updated research on neuroprotection in glaucoma, and summarize potential agents investigated so far. Data sources The data this were collected from PubMed Google Scholar databases published English up to September 2012, with keywords including glaucoma , retinal ganglion cells both alone combination. Publications past ten years selected, but important older articles not excluded. Study selection Articles about selected reviewed, those that are cited identified by...
The purpose of this study was to evaluate changes in choroidal thickness (CT) advanced or late-stage primary angle closure glaucoma (PACG) patients who had undergone trabeculectomy.This included 23 eyes with PACG that required trabeculectomy. Enhanced depth imaging optical coherence tomography used measure CT before and 7 days after relationships between IOP axial length were explored.At all nine macular locations, significantly higher trabeculectomy, the exception two sites. at locations...
High myopia is among the most common causes of vision impairment, and it mainly characterized by abnormal elongation axial length, leading to pathologic changes in ocular structures. Owing close relationship between high glaucoma, association intraocular pressure (IOP) progression has garnered attention. However, whether lowering IOP can retard unclear. On reviewing previous studies, we suggest that plays a role progressive length myopia, particularly wherein sclera more remodeled. Based on...
Purpose: To assess the longitudinal changes in crystalline lens persistent non-myopic and myopic children. Methods: Four cohorts of children were recruited from Guangzhou, China, first year kindergarten (G0, n = 1129), primary school (G1, 1324), fourth (G4, 1854), junior high (G7, 867) 2018 followed up annually for 2 years. All received cycloplegic autorefraction ocular biometry measurement. Children classified into categories non-myopia (PNM; spherical equivalent refraction [SER] ≥−0.5...
Pathological myopia (PM) and its associated complications can lead to permanent vision loss. However, the cellular mechanisms underlying PM development remain unclear. To identify metabolic alterations that may contribute pathophysiology of PM, we performed non-targeted metabolomics analysis using ultra-high-performance liquid chromatography with tandem mass spectrometry in age- sex-matched patients (n = 30) individuals without as controls 30). Targeted insulin microarray were used validate...
The beneficial effects of increasing outdoor physical activity time on children's myopia onset and well-being are widely acknowledged. However, in countries with competitive educational systems, such as China, parents school administrators may be relatively reluctant to increase the extracurricular for children due concerns that this action will compromise academic performance.
Purpose: Blood-based examination tools for glaucoma diagnosis in clinical practice, which can be useful screening patients when traditional ophthalmic examinations cannot utilized, are not available thus far. This study aimed to identify circulating microRNAs (miRNAs) associated with primary open-angle (POAG) and explore their utility as diagnostic markers. Methods: A total of 136 POAG controls were enrolled. Next-generation RNA sequencing was used the expression profile miRNAs set,...
Abstract Glaucoma is a common neurodegenerative disease and leading cause of irreversible blindness worldwide. Retinal microglia-mediated neuroinflammation involved in the process optic nerve damage, but mechanisms driving this microglial activation remain mostly elusive. Previous investigations reported that microRNAs are associated with retinal reaction neural apoptosis. In present study, we found microRNA-93-5p (miR-93) played key role cells vivo vitro. The miR-93 level was significantly...
Purpose: We performed single-cell RNA sequencing (scRNA-seq), an unbiased and high-throughput single cell technology, to determine phenotype function of peripheral immune cells in patients with diabetic macular edema (DME). Methods: Peripheral blood mononuclear (PBMCs) were isolated from DME healthy controls (HC). The samples loaded on the Chromium platform (10x Genomics) for sequencing. R package Seurat v3 was used data normalizing, clustering, dimensionality reduction, differential...
To develop an artificial intelligence (AI) system that can predict optical coherence tomography (OCT)-derived high myopia grades based on fundus photographs.In this retrospective study, 1,853 qualified photographs obtained from the Zhongshan Ophthalmic Center (ZOC) were selected to AI system. Three retinal specialists assessed corresponding OCT images label photographs. We developed a novel deep learning model detect and myopic maculopathy according atrophy (A), traction (T),...