A5101514988- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Neutropenia and Cancer Infections
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Blood disorders and treatments
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Cervical and Thoracic Myelopathy
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Chemotherapy-related skin toxicity
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
- Meningioma and schwannoma management
- interferon and immune responses
Second Military Medical University
2015-2025
Shanghai Changzheng Hospital
2018-2025
Henan Provincial People's Hospital
2022-2024
Zhengzhou University
2022-2024
Henan University
2023
Shandong First Medical University
2021-2023
Shandong Provincial QianFoShan Hospital
2021-2023
Shandong Tumor Hospital
2021
East China Normal University
2018-2019
Sequenom (United States)
2015
Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event bone. microRNA-124 (miR-124) has been proved inhibit progression, whereas its effect on not reported. Therefore, this study aimed investigate role underlying mechanism miR-124 cancer. In situ hybridization (ISH) was used detect expression tissues metastatic tissues. Ventricle injection model...
Abstract Background To date, no study has systematically explored the potential role of serum metabolites and lipids in diagnosis small cell lung cancer (SCLC). Therefore, we aimed to conduct a case-cohort that included 191 cases SCLC, 91 patients with adenocarcinoma, 82 squamous carcinoma, 97 healthy controls. Methods Metabolomics lipidomics were applied analyze different these patients. The SCLC model (d-model) was constructed using an integrated machine learning technology training cohort...
The surgical treatment of upper cervical spine metastases are controversial up to now. By summarizing and analyzing the clinical data involved treated surgically in our center, we mainly aimed investigate decisions outcomes so as provide more references for this special complex metastasis. We evaluated patients' pre- post-operative neck pain neurologic function with paired t test, followed by statistics selection approaches, ways reconstruction, related complications. Moreover, Kaplan–Meier...
Abstract Breast cancer is prone to form bone metastases and subsequent skeletal‐related events (SREs) dramatically decrease patients’ quality of life survival. Prediction early management lesions are valuable; however, proper prognostic models inadequate. In the current study, we reviewed a total 572 breast patients in three microarray data sets including 191 381 metastases‐free. Gene set enrichment analysis (GSEA) indicated less aggressive low‐grade features with compared metastases‐free...
11503 Background: The limited efficacy of current treatments for chordoma underscores the need novel therapeutic options. Immune checkpoint inhibitors (ICI) have changed landscape cancer treatment but are rarely investigated chordomas. Additionally, no established biomarkers reliably predict ICI and targeted therapies in this context. Methods: This investigator-initiated, single-arm, phase 2 trial evaluated safety camrelizumab (anti-programmed death 1, PD-1) combined with apatinib (a...
Aim: Because of the severe morbidity and mortality gastric cancer, discovering new candidate drugs has been an urgent issue. The close association between histone deacetylase 6 (HDAC6) cancer makes development HDAC6-targeted anti-gastric a viable idea. Methods & results: Carbenoxolone disodium was identified as novel HDAC6 inhibitor. Cellular thermal shift assay, surface plasmon resonance assay molecular docking confirmed its binding ability to HDAC6. Cell viability, wound healing transwell...
Clinical performance of a low coverage, cost, massively parallel sequencing (MPS)-based assay to stratify risk trisomy 21, 18, and 13 pregnancies was determined.The study included 1100 samples with birth outcome or karyotype results, comprising low-risk patients (84.2%) negative for indications from maternal age, serum screening, ultrasound, family history, high-risk (15.8%) at least one the aforementioned indications. Cell free DNA (cfDNA) extracted plasma. Library preparation incorporated...
The aim of this study is to provide some useful insights into the treatments, outcomes, and prognostic factors patients with breast cancer spine metastases (BCSM).We report a retrospective case series analyzing 87 BCSM who underwent surgical interventions. Independent for SMFS OS were extracted using univariate multivariate analyses, Kaplan-Meier method Cox proportional hazards model.The mean time between primary diagnoses spinal was 46.8 (median 41, range 0-147 months) months. analysis...
A retrospective study was performed.As predictors of intraoperative blood loss have not yet been well defined, the objective present is to develop a model predict amount in metastatic spine tumor surgery.Massive huge challenge surgery. Misjudgment preoperative planning may result disastrous consequences.Enrolled this analysis were 392 patients who received 423 surgeries vertebrectomy and reconstruction our hospital between 2011 2017. Risk factors for high-volume identified by univariate...
Unaffordable medical treatment and inflated drug prices have become a challenging issue for lawmakers worldwide. To reduce the financial burden standardize pharmaceutical market, Chinese government has issued several detailed regulations, including measures of recruitment procurement in one volume purchasing to not only ensure high quality approved drugs but also lower cost production sell procedure. In this work, thorough overview enforcement these we attempted critically analyze data our...
Breast cancer (BC) is characterized by high incidences of bone metastases. Current treatment strategies for BC metastases primarily focused on breaking the 'vicious osteolytic cycle'. Platelet-activating factor (PAF) a potent phospholipid mediator, which has previously reported biological activities in progression and osteoclast differentiation activating its receptor PAF (PTAFR). However, role mediation remains elusive. In present study, it was revealed that upregulation PTAFR associated...
Synovial sarcoma (SS) is a soft tissue that rarely occurs in the spine, and minimal number of cases have been reported literature. Spinal SS challenging diagnosis treatment has poor prognosis. The aim this study was to summarize analyse clinical features outcomes patients with spinal SS. A total 16 admitted our institution were reviewed retrospectively. General information, radiological findings strategies collected. These followed up regarding their continuing treatment, local or distant...
Patients with breast cancer are often afflicted by bone metastases, while the establishment and growth of metastases depend on interaction between cells host environment. Moreover, osteoblasts, which play a vital role in survival colonization, can form an osteogenic niche early stage metastases. Also, it is widely accepted that there genetic determinant during Nephronectin (NPNT) extracellular matrix protein has shown biological activities osteoblasts differentiation. But NPNT mediating...
Epidermal growth factor-like repeats and discoidin I like domain 3 (EDIL3) is an integrin ligand which implicated in bone metabolism marrow myelopoiesis. Recently, myeloid derived suppressor cells (MDSCs) as osteoclast progenitor have been demonstrated several kinds of cancers including breast cancer. In this paper we explored the association between tumor EDIL3 MDSCs a murine cancer model. Knockdown MDA-MB-231 inhibited expansion induced marrow. However, generation vitro was not affected by...
Background: Pegylated recombinant human granulocyte colony-stimulating factors (PEG-rhG-CSFs) are more commonly and widely used than (rhG-CSFs) in preventing chemotherapy-induced neutropenia patients with stage II-IV breast cancer. To reduce the financial burden on these patients, corresponding medical insurance directory needs to be revised. Objectives: evaluate cost-effectiveness of PEG-rhG-CSF versus rhG-CSF cancer central China. Methods: Two Markov models, a chemotherapy model...
This retrospective analysis aimed to evaluate the clinical outcomes and cost-effectiveness of long-acting granulocyte-colony stimulating factor as primary prophylaxis neutropenia caused by chemotherapy for breast cancer.Patients with cancer who received long- or short-acting were enrolled in this study, incidences compared between two groups. A decision-analytic a Markov model used compare health benefits costs utilizing vs from perspective Chinese service system. Subsequently, one-way...
There is no sensitive and effective method to predict radiation-induced myocardial damage (RIMD). The aim of this study was explore plasma biomarkers for early prediction RIMD after radiotherapy (RT) in lung cancer patients a rat model. Biomarker levels were measured samples collected before thoracic RT from 17 patients. For the animal model, single radiation dose 40 Gy delivered cardiac apex female Wistar rats. Control rats received sham irradiation (0 Gy). Dynamic biomarker detection...
BACKGROUND Preferentially expressed antigen of melanoma (PRAME) is known as a tumor-associated that altered in variety malignancies, including lung cancer. However, the role PRAME cancer remains unclear. MATERIAL AND METHODS We analyzed expression human adenocarcinomas and studied function using small interfering RNA (siRNA)-induced gene knockdown cell lines PC9 A549. RESULTS found down-regulated adenocarcinomas. Knockdown promoted proliferation suppressed apoptosis A549 cells. CONCLUSIONS...
Giant cell tumor of bone (GCTB), one the most common primary tumors, leads to extensive destruction. However, mechanisms underlying GCTB progression remain elusive and prognostic factors treatment targets are required. In current study, we explored function chemokine family member CCL20 in progression.We expression stromal cells (GCTSCs) using microarray. Clinical analyses role were performed based on patient cohort our institution. The proliferation was evaluated by MTS assay, migration...