A5100736900- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Oral and Maxillofacial Pathology
- RNA modifications and cancer
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Brain Metastases and Treatment
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Biosensors and Analytical Detection
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
General Hospital of Shenyang Military Region
2025
Shanghai Changzheng Hospital
2011-2024
Second Military Medical University
2015-2024
Southeast University
2023
Beijing Friendship Hospital
2022
Capital Medical University
2022
Northwest University
2022
Hospital of the University of Pennsylvania
2021
Yixing People's Hospital
2020
The First People's Hospital of Wenling
2020
An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching, where cells switch from a highly proliferative, poorly invasive to invasive, less proliferative one. This may hold significant implications not just for metastasis, but also therapy resistance. We demonstrate switching and subsequent resistance can be guided by changes expression receptors involved the noncanonical Wnt5A signaling pathway, ROR1 ROR2. ROR2 are inversely expressed melanomas negatively...
Metformin, an ancient drug commonly used for treating type II diabetes, has been associated to anti-cancer capacity in a variety of developing cancers, though the mechanism remains elusive. Here, we aimed examine inhibitory effect metformin osteosarcoma. Herein, demonstrated that treatment blocked proliferation progression by causing accumulation G2/M phase U2OS and 143B cells. Furthermore, triggered programmed cell death process osteosarcoma lines. Further research indicated induction...
Background: In recent decades, long non-coding RNAs (lncRNAs) have been reported as crucial functional regulators involved in ovarian cancer.In the present study, we explored how lncRNA RHPN1-AS1 influences progression of epithelial cancer (EOC) through tumor cell-dependent mechanisms.Results: The expression EOC tissues was higher than that para-cancerous control tissues.High closely associated with poor prognosis patients.N6methyladenosine (m6A) improved stability methylation transcript by...
Chordoma in the spine is relatively rare, and minimal information has been published literature regarding this subject. Moreover, there are controversies over prognostic factors of disease.A retrospective analysis chordoma was performed by survival analysis. Local relapse-free (LRFS) overall (OS) were analyzed from date surgery to local recurrence death. The LRFS OS rates estimated using Kaplan-Meier method identify potential factors. Factors with P values ≤ .1 subjected multivariate Cox...
Abstract The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 an essential co-activator signaling. Importantly, absent from tumors originating normal cellular counterparts and overexpressed many cancers including HCC. But mechanism for overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role development It was found our study both primary HCC bone metastasis specimens; loss inhibited...
Here we report that mice deficient for the proteasome activator, REGγ, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts. Interestingly, massive increase REGγ in skin tissues or cells resulting from induces activation p38 mitogen-activated protein kinase (MAPK/p38). Blocking MAPK prevents elevation HaCaT treatment. AP-1, downstream effector MAPK/p38,...
Many cancer cells require more glycolytic adenosine triphosphate production due to a mitochondrial respiratory defect. However, the roles of defects in development and progression remain unclear. To address role transcriptomic regulation by liver cells, we performed gene expression profiling for three different cell models defects: with chemical inhibition (rotenone, thenoyltrifluoroacetone, antimycin A, oligomycin), DNA depletion (Rho0), harboring (SNU354 SNU423). By comparing models,...
This study aimed to explore the biological functions of long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) in bladder cancer cells. For expressions lncRNA-ATB, miR-126, and KRAS, T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then cell viability, migration, invasion, apoptosis as well protein levels apoptosis-related factors PI3K/AKT mTOR signal pathways measured. The relationships lncRNA-ATB miR-126 KRAS analyzed Dual-Luciferase...
A retrospective study of 36 patients with metastatic hepatocellular carcinoma (HCC) the mobile spine was performed by survival analysis.To discuss factors that may affect outcomes HCC spinal metastases.HCC is a rare tumor in Western countries. However, common Far East (Taiwan, Korea, mainland China), where hepatitis B virus epidemic. As mean time has largely increased recent years, it now more to encounter patient epidural cord compression caused metastases clinic.The univariate and...
Abstract Breast cancer is prone to form bone metastases and subsequent skeletal‐related events (SREs) dramatically decrease patients’ quality of life survival. Prediction early management lesions are valuable; however, proper prognostic models inadequate. In the current study, we reviewed a total 572 breast patients in three microarray data sets including 191 381 metastases‐free. Gene set enrichment analysis (GSEA) indicated less aggressive low‐grade features with compared metastases‐free...
The expression of microRNA-215 (miR-215) in non-small cell lung cancer (NSCLC) tissues and the effects miR-215 on proliferation migration NSCLC cells were investigated. qRT-PCR was used to detect paired normal tumor-adjacent tissues; MTT assay, transwell assay soft-agar vitro evaluate role proliferation, clonality cells, after transfecting mimics line A549 or H1299. significantly decreased compared Overexpression resulted reduction clonality, while downregulation H1299 could promote...