A5052195331- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Lysosomal Storage Disorders Research
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Vitamin D Research Studies
- RNA modifications and cancer
- Regulation of Appetite and Obesity
- Trypanosoma species research and implications
- Liver Disease Diagnosis and Treatment
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Public Health and Nutrition
- Catalysis and Oxidation Reactions
- Bone health and osteoporosis research
Capital Institute of Pediatrics
2016-2025
Jiangsu University
2023-2025
CanSino (China)
2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2023-2024
Guangzhou Medical University
2012-2024
Université Paris Cité
2022-2024
Laboratoire de Psychologie et d’Ergonomie Appliquées
2022-2024
Université Gustave Eiffel
2022-2024
Queensland University of Technology
2022-2024
Pulmonary fibrosis (PF) is a lethal fibrotic lung disease. The role of lncRNAs in multiple diseases has been confirmed, but the and mechanism lncRNA zinc finger antisense 1 (ZFAS1) progression PF need to be elucidated further. Here, we found that ZFAS1 was upregulated bleomycin (BLM)-induced rats tissues transforming growth factor-β1 (TGF-β1)-treated HFL1 cells, positively correlated with expression solute carrier family 38 member (SLC38A1), which an important regulator lipid peroxidation....
Heterostructures comprising lanthanide-doped upconversion nanoparticles (DUCNPs) and metal–organic frameworks (MOFs) are emerging as promising nanosystems for integrating medical diagnosis treatment. Here, the DUCNP@Mn–MOF nanocarrier was developed, which showed good efficiency loading delivering a cytotoxic antitumor agent (3-F-10-OH-evodiamine, FOE). The combined advantages of pH-responsive peroxidase-like properties Mn–MOF unique optical features DUCNPs granted DUCNP@Mn–MOF/FOE system...
Abstract Objective The aim of this study is to assess the association between degree insulin resistance and different components metabolic syndrome among Chinese children adolescents. Moreover, determine cut-off values for homeostasis model assessment (HOMA-IR) at MS risk. Methods 3203 aged 6 18 years were recruited. Anthropometric biochemical parameters measured. Metabolic (MS) was identified by a modified Adult Treatment Panel III (ATP III) definition. HOMA-IR index calculated normal...
Automated vehicles (AVs) are going to enter public roads in the near future and will inevitably encounter more than one pedestrian on roads. Very little is known about how multiple pedestrians interact with AVs their external human–machine interfaces (eHMIs). This study investigates social influence of others decision-making process during initial encounters AVs. In a virtual reality experiment, 26 male 55 female participants three experimental conditions made crossing decisions – either...
Background The differential impact of serum lipids and their targets for lipid modification on cardiometabolic disease risk is debated. This study used Mendelian randomization to investigate the causal relationships underlying mechanisms. Methods Genetic variants related profiles were sourced from Global Lipids Genetics Consortium. Summary data 10 diseases compiled both discovery replication sets. Expression quantitative trait loci relevant tissues employed evaluate significant...
The molecular mechanisms underlying protein kinase C (PKC) isozyme-mediated control of cell growth and cycle progression are poorly understood. Our previous analysis PKC isozyme regulation in the intestinal epithelium situ revealed that multiple members family undergo changes expression subcellular distribution precisely as cells cease proliferating mid-crypt region, suggesting activation one or more these molecules is involved negative this system (Saxon, M. L., Zhao, X., Black, J. D....
The mechanisms underlying control of cell growth and differentiation in epithelial tissues are poorly understood. Protein kinase C (PKC) isozymes, members a large family serine/threonine kinases fundamental importance signal transduction, have been increasingly implicated the regulation growth, differentiation, function. Using rat intestinal epithelium as model system, we examined PKC-specific activity well individual PKC isozyme expression distribution (i.e., activation status) cells situ....
Abstract Background Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated ( FTO ) gene region is with body index (BMI) European children adults. A significant of same risk allele has been described Asian adult populations, but results are conflicting. In addition, no replication conducted adolescents ancestry. Methods population-based survey was carried out among 3503 (6-18...
OBJECTIVE Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs among other ethnicities are not fully described, especially children. Among previously SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, rs10938397, or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF,...
Data about metabolic syndrome (MetS) in children is limited China. We aimed to assess the prevalence of MetS related components, and their association with obesity. were collected as part a representative study on among 19593 children, aged 6-18 years old Beijing. General obesity was assessed by body mass index (BMI) central waist circumference. Finger capillary blood tests used triglyceride (TG), total cholesterol (TC) impaired fasting glucose (IFG). Vein samples from subsample 3814 10-18...
Abstract Background Although attention to metabolic syndrome (MetS) in children has increased, there is still no universally accepted definition and its pathogenesis remains unclear. Our aim was compare the current definitions of childhood MetS a Chinese cohort examine clustering pattern risk factors, particularly inclusion leptin adiponectin as additional components. Methods 3373 schoolchildren aged 6 18 years were recruited. Anthropometric biochemical parameters adipokines measured....
Childhood obesity is a complex disease that influenced by both genetic and environmental factors. The authors' aim was to determine whether sedentary behavior physical activity modulate the association between single nucleotide polymorphisms (SNPs) risk in Chinese children. A population-based study carried out 2,848 children (6-18 years of age) Beijing, China, 2004. It included 1,229 obese cases 1,619 normal-weight controls. Lifestyle information collected through use validated...
Serum lipid trends in children and adolescents are predictors of the future prevalence cardiovascular disease adults.Data were obtained from cross-sectional studies conducted 2004 2014. A total 3249 aged 6-18 years included present study; serum cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), triglycerides (TG) measured.Overall, upward mean TC, non-HDL-C, LDL-C levels, geometric TG observed (all P < 0.001). Mean HDL-C levels significantly decreased between 2014 (from...
The influences of different land uses associated with human activities on soil quality and the redistribution heavy metal in have been widely concerned. Surface samples were obtained to assess comprehensive a typical red region southern China, combining pollution evaluation fertility evaluation. It can be learned from results that overall level was at medium lower level, risk study area few regions had reached warning line slight line, there potential pollution. TOPSIS showed mainly good...
Abstract Objective The aim was to investigate the mediating role of inflammatory biomarkers in causal effect body composition on glycaemic traits and type 2 diabetes. Methods A retrospective observational study a Mendelian randomization (MR) were used. Observational analyses performed using data from 4717 Chinese children adolescents aged 6–18 years who underwent dual‐energy X‐ray absorptiometry for composition. MR based summary statistics UK Biobank, deCODE2021, Meta‐Analysis Glucose...
Objective . To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, insulin concentrations well body size parameters pubertal development were evaluated a large population Chinese children/adolescents (<mml:math...
A transient increase in insulin resistance (IR) is a component of puberty. We investigated the impact body composition and adipokines on IR during puberty Chinese children. This study included 3223 schoolchildren aged 6–18 years. was calculated using homeostasis model assessment (HOMA-IR). revealed that mass index (BMI) waist circumference increased gradually both genders, while fat-mass percentage (FAT%) steadily only girls. Change leptin showed striking sexual dimorphisms: girls puberty,...