A5071277360- Diatoms and Algae Research
- Yersinia bacterium, plague, ectoparasites research
- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
- Vector-borne infectious diseases
- Zoonotic diseases and public health
- Marine Biology and Ecology Research
- Bacillus and Francisella bacterial research
- Genomics and Phylogenetic Studies
- Water Quality Monitoring and Analysis
- Protist diversity and phylogeny
- Pharmacological Effects of Natural Compounds
- Algal biology and biofuel production
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Marine Toxins and Detection Methods
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Escherichia coli research studies
- Marine Biology and Environmental Chemistry
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal plant biology
- Paleontology and Stratigraphy of Fossils
National Institute for Communicable Disease Control and Prevention
2016-2025
Air Force Medical University
2015-2025
Center for Disease Control
2025
Xiamen University
2015-2024
Jinan University
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2023-2024
Chinese Center For Disease Control and Prevention
2013-2023
Zunyi Medical University
2023
State Key Laboratory of Infectious Disease Prevention and Control
2012-2022
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas dietary fibers or probiotics on functional symptoms, and identify modulations microbiota relevance. conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + D: Bifidobacterium animalis subsp. lactis HN019 Lacticaseibacillus...
Mycoplasma pneumoniae (MP) is a leading cause of community-acquired pneumonia (CAP), accounting for 10–40% cases in children. In China, the high prevalence macrolide-resistant MP (MRMP) and recurrent epidemics place significant burden on healthcare system. Leveraging data from over 1.6 million cases, this study provides comprehensive analysis epidemiological characteristics across China. Seasonal patterns revealed three distinct transmission zones Transmission Zone 1 exhibited two annual...
Introduction: Metastasis and drug resistance contribute substantially to the poor prognosis of colorectal cancer (CRC) patients. However, epigenetic regulatory mechanisms by which CRC develops metastatic drug-resistant characteristics remain unclear. This study aimed investigate role miR-302a in metastasis molecular-targeted elucidate underlying molecular mechanisms. Methods: expression cell lines patient tissue microarrays was analyzed qPCR fluorescence situ hybridization. The roles...
Resting cells represent a survival strategy employed by diatoms to endure prolonged periods of unfavourable conditions. In the oceans, many sink at end their blooming season and therefore need cold dark conditions in deeper layers water column. How they survive these is largely unknown. We conducted an integrative analysis encompassing methods from histology, physiology, biochemistry, genetics reveal biological mechanism resting-cell formation model diatom Thalassiosira pseudonana....
In China, great differences in economy, social characteristics and hygiene exist between developing developed regions. A comparative study of infectious diarrhea two regions was needed. Three groups diarrheal patients were collected: children ≤5 year-olds from Beijing (developed region) Henan Province (developing region), adults over 18 Beijing. questionnaire used to survey feces samples examined for 16 enteropathogens. We enrolled 1422 1047 region 755 region. Virus positive rates 32.98%...
Gastric cancer is a frequently occurring with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric still urgently required. Ginkgolic acid (GA), botanical drug, extracted from the seed coat of Ginkgo biloba L. various bioactive properties, including anti-tumor. Unfortunately, if GA has antitumor effect on underlying molecular mechanisms have yet to be investigated. In present study, we found that markedly reduced cell viability....
Boosting and prolonging SARS-CoV-2 vaccine-elicited immunity is paramount for containing the COVID-19 pandemic, which wanes substantially within months after vaccination. Here we demonstrate that unique strain of probiotic Lactobacillus plantarum GUANKE (LPG) could promote SARS-CoV-2-specific immune responses in both effective memory phases through enhancing interferon signaling suppressing apoptotic inflammatory pathways. Interestingly, oral LPG administration promoted neutralization...
A taxonomic study was carried out on bacterial strain H3(T), which isolated from the toxic marine diatom Pseudo-nitzschia multiseries. Cells of H3(T) were Gram-stain-negative, rod-shaped, non-motile and capable reducing nitrate to nitrite, but not denitrification. Growth observed at NaCl concentrations 1-9%, pH 6-12 10-37 °C. It unable degrade aesculin or gelatin. The dominant fatty acids (>10 %) C18:1ω7c/ω6c (summed feature 8) C16:0. respiratory ubiquinone Q10. major lipids...
Investigation of how diatoms cope with the rapid fluctuations in iron bioavailability marine environments may facilitate a better understanding mechanisms underlying their ecological success, particular ability to proliferate rapidly during favorable conditions. In this study, using vivo biochemical markers and whole-cell iTRAQ-based proteomics analysis, we explored cellular responses associated reactive oxygen species (ROS) production cell fate decision early response Fe limitation centric...
The distribution of Yersinia enterocolitica in slaughtered pigs China was studied. A total 8,773 samples were collected and examined from different pig abattoirs 11 provinces 2009 to 2011. Of these, 4,495 oral-pharyngeal swab (tonsils) pigs, 1,239 intestinal contents, 3,039 feces or local pigpens. data showed that 1,132 strains obtained, which the isolation rate for 19.53% (878/4,495) tonsil samples, 7.51% (93/1,239) 5.30% (161/3,039) feces. 850 pathogenic strains, except three bioserotype...
Silicon is a critical element for diatom growth; however our understanding of the molecular mechanisms involved in intracellular silicon responses are limited. In this study, an iTRAQ-LC–MS/MS quantitative proteomic approach was coupled with established synchrony technique to reveal global metabolic silicon-response model Thalassiosira pseudonana subject starvation and readdition. Four samples, which corresponded time starvation, girdle band synthesis, valve formation, right after daughter...
We developed a multilocus sequence typing (MLST) scheme and used it to study the population structure evolutionary relationships of three pathogenic Yersinia species. MLST these species showed complex two clusters, one composed pseudotuberculosis pestis other enterocolitica. Within first cluster, predominant Y. type 90 (ST90) was linked ST43 by locus difference, 81.25% strains were from serotype O:1b, supporting hypothesis that descended O:1b pseudotuberculosis. also found...
A case of primary pneumonic plague (PPP) caused by Yersinia pestis is reported. This occurred in the largest area China. The patient died after contact with a dog that had captured an infected marmot. Three 151 contacts were shown to be positive for antibody against F1 antigen indirect hemagglutination assay, but none clinical symptoms. There was no secondary case.