Xinyan Wang

ORCID: 0000-0001-5428-4916
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About
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Research Areas
  • Acute Ischemic Stroke Management
  • Reproductive System and Pregnancy
  • Head and Neck Surgical Oncology
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Endometrial and Cervical Cancer Treatments
  • Folate and B Vitamins Research
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • Birth, Development, and Health
  • Ovarian function and disorders
  • Salivary Gland Tumors Diagnosis and Treatment
  • Reproductive Biology and Fertility
  • Radiomics and Machine Learning in Medical Imaging
  • Nutritional Studies and Diet
  • Estrogen and related hormone effects
  • MRI in cancer diagnosis
  • Cytokine Signaling Pathways and Interactions
  • Assisted Reproductive Technology and Twin Pregnancy
  • Aquaculture disease management and microbiota
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Ferroptosis and cancer prognosis
  • Immune Response and Inflammation
  • Atrial Fibrillation Management and Outcomes
  • Immune Cell Function and Interaction
  • Venous Thromboembolism Diagnosis and Management

Capital Medical University
2015-2025

Beijing Tian Tan Hospital
2021-2025

Inner Mongolia Medical University
2025

Shandong Jiaotong University
2025

Northeast Electric Power University
2024-2025

Nanjing Medical University
2019-2025

Shandong University of Technology
2025

Chinese PLA General Hospital
2022-2024

Anhui University
2012-2024

Mongolian National University of Medical Sciences
2024

Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas dietary fibers or probiotics on functional symptoms, and identify modulations microbiota relevance. conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + D: Bifidobacterium animalis subsp. lactis HN019 Lacticaseibacillus...

10.1080/19490976.2023.2197837 article EN cc-by-nc Gut Microbes 2023-04-20

No definitive conclusion can be made on the best choice of anesthesia for people with acute posterior circulation stroke during endovascular treatment. Only a few observational studies have focused this topic in recent years, and they differing conclusions. To examine whether conscious sedation (CS) is feasible alternative to general (GA) treatment patients stroke. A randomized parallel-group exploratory trial blinded end point evaluation (Choice Anesthesia Endovascular Treatment Acute...

10.1001/jamaneurol.2022.3018 article EN JAMA Neurology 2022-09-26

Pulmonary fibrosis is an irreversible chronic progressive fibroproliferative lung disease, which usually has a poor prognosis. Previous studies have confirmed that the transplantation of bone marrow mesenchymal stem cells (MSCs) significantly reduces damage in number animal models. However, underlying mechanism involved this process remains to be elucidated. In present study, bleomycin (BLM)‑induced female Wister rat model was established. At 0 or 7 days following BLM administration, rats...

10.3892/mmr.2014.2981 article EN cc-by-nc Molecular Medicine Reports 2014-11-19

Aims The role of tea consumption in the primary prevention atherosclerotic cardiovascular disease remains unclear cohort studies. This prospective study aimed to investigate associations with risk and all-cause mortality. Methods We included 100,902 general Chinese adults from project Prediction for ASCVD Risk China (China-PAR) 15 provinces across since 1998. Information on was collected through standardized questionnaires. Outcomes were identified by interviewing participants or their...

10.1177/2047487319894685 article EN European Journal of Preventive Cardiology 2020-01-09

To investigate the diagnostic performance of diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) magnetic resonance (MRI), and combination both in differential diagnosis lymphoma inflammation orbit.This retrospective study was approved by Institutional Review Board informed consent requirement waived. A total 53 patients underwent preoperative 3T MRI. Parameters DWI DCE MRI were evaluated these 30 with orbital 23 inflammation. The using receiver operating characteristic curve...

10.1002/jmri.25480 article EN Journal of Magnetic Resonance Imaging 2016-09-20

Immune checkpoint inhibitors (ICIs) have achieved promising effects in patients with non-small cell lung cancer (NSCLC). However, not all NSCLC benefit from immunotherapy. There is an urgent need to explore biomarkers that could predict the survival outcomes and therapeutic efficacy advanced treated In this study, we aimed assess changes peripheral blood lymphocyte subsets their association clinical prognosis of immunotherapy.A total 276 were enrolled. Peripheral including CD4+ T cells, CD8+...

10.1186/s12890-022-01951-x article EN cc-by BMC Pulmonary Medicine 2022-04-28

Non-alcoholic fatty liver disease (NAFLD) represents a complex complication of type 2 diabetes mellitus (T2DM). Oxymatrine (OMT) is an alkaloid extracted from Sophora flavescens with broad pharmacological effects. However, there currently lack research on OMT in the field NAFLD. The present study aimed to explore effects and underlying mechanisms oxymatrine treating T2DM mice model was induced by high-fat diet (HFD) combined streptozotocin (STZ) injection male C57BL/6 J mice. Animals were...

10.1016/j.biopha.2024.116491 article EN Biomedicine & Pharmacotherapy 2024-03-26

Accurate diagnosis and prognosis prediction are conducive to early intervention improvement of medical care for natural killer/T cell lymphoma (NKTCL). Artificial intelligence (AI)-based systems developed based on nasopharynx magnetic resonance imaging. The diagnostic achieve areas under the curve 0.905–0.960 in detecting malignant nasopharyngeal lesions distinguishing NKTCL from carcinoma independent validation datasets. In comparison human radiologists, show higher accuracies than resident...

10.1016/j.xcrm.2024.101551 article EN cc-by-nc-nd Cell Reports Medicine 2024-05-01

Traditional Chinese medicine (TCM) has played an indispensable role in clinical diagnosis and treatment. Based on a patient’s symptom phenotypes, computation-based prescription recommendation methods can recommend personalized TCM using machine learning artificial intelligence technologies. However, owing to the complexity individuation of current cannot obtain good performance. Meanwhile, it is very difficult conduct effective representation for unrecorded terms existing knowledge base. In...

10.1155/2022/4845726 article EN cc-by BioMed Research International 2022-02-17

Abstract Purpose This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy patients with advanced gastric cancer their relationship n therapeutic efficacy clinical prognosis. Methods Peripheral subsets, including CD4 + T cells, CD8 CD4+/CD8 ratio, NK Treg B were collected from 195 who admitted First Hospital of Shanxi Medical University January 2020 October 2021, at time diagnosis cancer, 3 cycles immunotherapy. T-tests...

10.1186/s12876-024-03168-0 article EN cc-by BMC Gastroenterology 2024-03-15

Abstract Background Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. ADAM33 (a disintegrin metalloproteinase 33) has been one of the most exciting candidate genes for asthma since its first association with in Caucasian populations. Recently, was shown to be associated excessive decline lung function COPD. The aim this study evaluate potential relationship between polymorphisms COPD a Han population northeastern China. Methods A total 312...

10.1186/1471-2350-10-132 article EN cc-by BMC Medical Genetics 2009-12-01

Background Millions of people rely on N95 filtering facepiece respirators to reduce the risk airborne particles and prevent them from respiratory infections. However, there are no respirator fit testing training regulations in China. Meanwhile, study has been conducted investigate various respirators. The objective this was whether obtained adequate when wearing (FFRs) used widely Methods Fifty adult participants selected using Chinese test panel donned 10 common models FFRs. Fit factors...

10.1371/journal.pone.0085299 article EN cc-by PLoS ONE 2014-01-21

Endoplasmic reticulum (ER) dysfunction is a potential contributor to the impaired repair capacity of periodontal tissue in diabetes mellitus (DM) patients. Restoring ER homeostasis thus critical for successful regenerative therapy diabetic tissue. Recent studies have shown that metformin can modulate DM-induced dysfunction, yet its mechanism remains unclear. Herein, we show high glucose elevates intracellular miR-129-3p level due exocytosis-mediated release failure and subsequently perturbs...

10.1021/acsnano.2c08146 article EN ACS Nano 2022-10-19

Introduction Preclinical studies have shown that oxygen therapy can improve ischaemic brain tissue tension, reduce reperfusion injury after revascularisation, promote neuroregeneration and inhibit inflammatory responses potentially exerting a beneficial effect endovascular treatment (EVT) in patients with acute stroke (AIS). However, the optimal fraction of inspired (FiO 2 ) during EVT under general anaesthesia is currently unknown. Therefore, we are conducting randomised controlled trial...

10.1136/bmjopen-2024-086234 article EN cc-by-nc-nd BMJ Open 2025-01-01
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