A5076258810- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cardiac Imaging and Diagnostics
- Transplantation: Methods and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Lipoproteins and Cardiovascular Health
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
Medical University of Vienna
2012-2025
Weill Cornell Medicine
2022-2025
Cornell University
2022-2025
NewYork–Presbyterian Hospital
2022-2025
New York Hospital Queens
2022-2025
FH Campus Wien
2024
Vienna General Hospital
2001-2024
New York Proton Center
2023
English Heritage
2023
Charlottesville Medical Research
2023
Importance It has been reported that women undergoing coronary artery bypass have higher mortality and morbidity compared with men but it is unclear if the difference decreased over last decade. Objective To evaluate trends in outcomes of US from 2011 to 2020. Design, Setting, Participants This retrospective cohort study at hospitals contributing Adult Cardiac Surgery Database Society Thoracic Surgeons included 1 297 204 patients who underwent primary isolated Exposure Coronary bypass. Main...
Chronic total occlusions (CTOs) of coronary arteries can be found in the context chronic or acute syndromes; sometimes they are an incidental finding those apparently healthy individuals undergoing imaging for preoperative risk assessment. Recently, invasive management CTOs has made impressive progress due to sophisticated preinterventional assessment, including advanced non-invasive imaging, availability novel and dedicated tools CTO percutaneous intervention (PCI), experienced...
Programmed death-1 (PD-1), an inhibitory receptor up-regulated on activated T cells, has been shown to play a critical immunoregulatory role in peripheral tolerance, but its alloimmune responses is poorly understood. Using novel alloreactive TCR-transgenic model system, we examined the functions of this pathway regulation CD4+ cell vivo. PD-L1, not PD-1 or PD-L2, blockade accelerated MHC class II-mismatched skin graft (bm12 (I-Abm12) into B6 (I-Ab)) rejection similar manner CTLA-4 blockade....
Graft patency is the postulated mechanism for benefits of coronary artery bypass grafting (CABG). However, systematic graft imaging assessment after CABG rare, and there a lack contemporary data on factors associated with failure association between clinical events CABG. We pooled individual patient from randomized trials to assess incidence its risk factors. The primary outcome was composite myocardial infarction or repeat revascularization occurring before imaging. A 2-stage meta-analytic...
BACKGROUND: Coronary artery bypass grafting (CABG) is the recommended mode of revascularization in patients with ischemic left ventricular dysfunction (iLVSD) and multivessel disease. However, contemporary percutaneous coronary intervention (PCI) outcomes have improved integration novel technologies refinement strategies, PCI often used clinical practice this population. There a lack evidence from randomized trials comparing state-of-the-art versus CABG for treatment iLVSD This was impetus...
Abstract Cardiac surgery may lead to myocardial damage and release of cardiac biomarkers through various mechanisms such as manipulation, systemic inflammation, hypoxia, cardioplegic arrest ischaemia caused by coronary or graft occlusion. Defining perioperative infarction (PMI) after presents challenges, the association between current PMI definitions postoperative outcomes remains uncertain. To address these European Association Cardio-Thoracic Surgery (EACTS) facilitated collaboration...
Graphical AbstractSV, saphenous vein. Parts of the figure were drawn using images from Servier Medical Art (smart.servier.com). by is licensed under a Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/).Open in new tabDownload slide
Background Limited data exist on sex differences in guideline‐recommended statin therapy for secondary prevention after coronary artery bypass surgery (CABG). We examined use CABG and the association between sex‐specific mortality. Methods Results Data from Austrian national cardiac registry federal social insurance claims database patients who underwent 2013 2021 were used. Multivariable logistic regression models calculated to obtain women‐to‐men odds ratios filling any high‐intensity...
Inducible costimulatory molecule (ICOS) plays a pivotal role in T cell activation and Th1/Th2 differentiation. ICOS blockade has disparate effects on immune responses depending the timing of blockade. Its transplantation immunity, however, remains incompletely defined. We used vascularized mouse cardiac allograft model to explore signaling at different time points after transplantation, targeting initiation (early blockade) or effector phase (delayed blockade). In major...
Abstract CD4+CD25+ regulatory T cells (TRegs) are critical for the acquisition of peripheral allograft tolerance. However, it is unclear whether TRegs capable mediating alloantigen-specific suppressive effects and, hence, contributing to specificity tolerant state. In current report we have used ABM TCR transgenic (Tg) system, a C57BL/6-derived strain in which CD4+ directly recognize allogeneic MHC-II molecule I-Abm12, assess capacity mediate allospecific effects. these mice, 5–6% Tg exhibit...
The antiplatelet treatment strategy providing optimal balance between thrombotic and bleeding risks in patients undergoing coronary artery bypass grafting (CABG) is unclear. We prospectively compared the efficacy of ticagrelor aspirin after CABG.We randomly assigned double-blind fashion scheduled for CABG to either 90 mg twice daily or 100 (1:1) once daily. primary outcome was composite cardiovascular death, myocardial infarction (MI), repeat revascularization, stroke 12 months CABG. main...