A5047074031- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Platelet Disorders and Treatments
- Hormonal and reproductive studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Menopause: Health Impacts and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hospital Admissions and Outcomes
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Asthma and respiratory diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Lipids, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2015-2025
Williams & Associates
2021-2023
Joint Commission
2023
University of Minnesota Rochester
2022
Johns Hopkins Bayview Medical Center
2006-2021
Association of Black Cardiologists
2021
Johns Hopkins Hospital
2016
VA Boston Healthcare System
2012
Brigham and Women's Hospital
2010-2012
AIM: The “2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease” provides an update to and consolidates new evidence since “2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Diagnosis Stable Ischemic Heart corresponding “2014 ACC/AHA/AATS/PCNA/SCAI/STS Focused Update Disease.” METHODS: A comprehensive literature search was conducted from September 2021 May 2022. Clinical studies, systematic reviews meta-analyses, other on human participants were identified...
Background —Rotational atherectomy with the Rotablator catheter has improved percutaneous treatment of certain coronary atherosclerotic lesions, but “no-reflow” phenomenon remains a serious complication. Because platelet activation by rotablation may contribute to no-reflow phenomenon, we developed an in vitro system test effect on platelets absence or presence GP IIb/IIIa receptor blockade abciximab. Methods and Results —Platelet-rich plasma (PRP) was prepared from 28 healthy human...
Abstract Aims Platelet activation and endothelial dysfunction contribute to adverse outcomes in patients with acute coronary syndromes (ACS). The goals of this study were assess the impact proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition on markers platelet ACS interaction among PCSK9, platelets, cells (ECs) left internal mammary artery (LIMA) vascular endothelium using specimens obtained during bypass surgery (CABG). Methods Results Acute enrolled Evolocumab trials...
Depression in patients with cardiovascular disease is associated increased risk of adverse clinical outcomes. Investigators have searched for potential biobehavioral explanations this risk. Platelet activation and response to serotonin an attractive mechanism. The aim the study was examine platelet signaling a group coronary artery (CAD) comorbid depression define relationship between complications.A total 300 CAD were enrolled (145 acute syndrome 155 stable CAD). assessed using Structured...
COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of released endothelial cells. We tested the effect P-selectin inhibition on biomarkers thrombosis patients with COVID-19. Hospitalized moderate were randomly assigned to receive either placebo or crizanlizumab, inhibitor, double-blind fashion. Crizanlizumab reduced levels 89%. increased D-dimer 77% decreased prothrombin fragment. There no significant differences between...
Individuals with COPD are disproportionately affected by social determinants of health that have been associated worse respiratory outcomes. This study evaluates the association perceived stress outcomes and distinct biologic mechanisms among former smokers COPD. Participants were assessed in an observational at baseline, 3-months, 6-months. Questionnaires (Perceived Stress Scale, PSS), symptoms incidence exacerbations. Generalized linear mixed models evaluated PSS score biomarkers platelet...
Background: Hormone therapy (HT) is associated with increased risk of both venous and arterial thrombosis, which are multifactorial in origin. Objectives: Our objectives were twofold: first, we sought to examine associations between endogenous serum sex hormone levels biomarkers thrombosis and/or coagulation postmenopausal nonusers. Second, separately studied the users considering fact that pattern circulating hormones different women taking exogenous hormones. Patients/Methods: We performed...